P-POD: Princeton Protein Orthology Database: GO3/Para922

This family has 61 members: 2 Arabidopsis thaliana, 8 Caenorhabditis elegans, 1 Danio rerio, 5 Dictyostelium discoideum, 19 Drosophila melanogaster, 6 Gallus gallus, 5 Homo sapiens, 7 Mus musculus, 4 Rattus norvegicus, 1 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Para922
61 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_568295.2 · TAIR:locus:2174648 (MPL1 · MUA22.18 · AT5G14180 · MUA22_18)MYZUS PERSICAE-INDUCED LIPASE 1⌘
A. thalianaNCBI:NP_179126.2 · TAIR:locus:2041834 (ATLIP1 · F15A23.3 · AT2G15230 · F15A23_3)Arabidopsis thaliana lipase 1⌘
C. elegansWB:WBGene00020016 (R11G11.14) · UniProtKB:O16956⌘
C. elegansWB:WBGene00008510 (F01G10.7) · UniProtKB:O17766⌘
C. elegansWB:WBGene00022642 (ZK6.7) · UniProtKB:O61866⌘
C. elegansWB:WBGene00009773 (F46B6.8) · UniProtKB:Q20449⌘
C. elegansWB:WBGene00010062 (F54F3.3) · UniProtKB:Q93789⌘
C. elegansWB:WBGene00019376 (K04A8.5) · UniProtKB:Q94252⌘
C. elegansWB:WBGene00021963 (Y57E12B.3) · UniProtKB:Q95XV1⌘
C. elegansWB:WBGene00013050 · UniProtKB:Q9U276
D. rerioUniProtKB:Q7ZTR9 · ZFIN:ZDB-GENE-040426-2737 (lipf)lipase, gastric⌘
D. discoideumdictyBase:DDB_G0268966 (DDB_G0268966) · UniProtKB:Q55EU1⌘
D. discoideumUniProtKB:Q55EU8 · dictyBase:DDB_G0268740 (DDB_G0268740)carboxylic ester hydrolase⌘
D. discoideumdictyBase:DDB_G0268964 (DDB_G0268964) · UniProtKB:Q55EU9⌘
D. discoideumUniProtKB:Q75JK5 · dictyBase:DDB_G0276083 (DDB_G0276083)carboxylic ester hydrolase⌘
D. discoideumUniProtKB:Q86KU7 · dictyBase:DDB_G0277723 (DDB_G0277723)carboxylic ester hydrolase⌘
D. melanogasterUniProtKB:O46107 · FB:FBgn0023496 (lip1 · Lip · Lip1 · CG7279 · dLip1 · Lipase1 · Dmlip1)Lipase 1⌘
D. melanogasterFB:FBgn0023495 (lip3 · Lipase-3 · Lip3 · LIP3 · CG8823 · Dmlip3 · Lipase3 · dLip3) · UniProtKB:O46108⌘
D. melanogasterFB:FBgn0033999 (CG8093 · CT22063) · UniProtKB:Q4V6L4⌘
D. melanogasterFB:FBgn0051091 (CG5990 · CG31091) · UniProtKB:Q8IMS3⌘
D. melanogasterFB:FBgn0032271 (CG7329) · UniProtKB:Q8T3X7⌘
D. melanogasterFB:FBgn0032981 (CG3635) · UniProtKB:Q9V9N3⌘
D. melanogasterFB:FBgn0051089 (CG31089 · CG5990) · UniProtKB:Q9VBK6⌘
D. melanogasterFB:FBgn0038070 (CG6753) · UniProtKB:Q9VG46⌘
D. melanogasterFB:FBgn0038069 (CG11608) · UniProtKB:Q9VG47⌘
D. melanogasterFB:FBgn0038068 (CG11600) · UniProtKB:Q9VG48⌘
D. melanogasterFB:FBgn0042207 (CG12294 · CG18530) · UniProtKB:Q9VG50⌘
D. melanogasterFB:FBgn0051871 (CG17087 · CG17099 · CG31871) · UniProtKB:Q9VKS5⌘
D. melanogasterFB:FBgn0043825 (CG18284 · BEST:GH10507 · Acp) · UniProtKB:Q9VKS9⌘
D. melanogasterFB:FBgn0032266 (CG18302) · UniProtKB:Q9VKT7⌘
D. melanogasterFB:FBgn0032265 (CG18301) · UniProtKB:Q9VKT8⌘
D. melanogasterUniProtKB:Q9VKT9 · FB:FBgn0032264 (CG6113 · dLip4 · Lip4)Lipase 4 · lipase 4⌘
D. melanogasterFB:FBgn0036996 (CG5932) · UniProtKB:Q9VPE9⌘
D. melanogasterFB:FBgn0031533 (BcDNA:RE45077 · CG2772) · UniProtKB:Q9VQQ5⌘
D. melanogasterFB:FBgn0034990 (CG11406) · UniProtKB:Q9W195⌘
G. gallusNCBI:XP_001234189 · ENTREZ:770870
G. gallusNCBI:XP_421657 · ENTREZ:423786
G. gallusNCBI:XP_421661 · ENTREZ:423789
G. gallusNCBI:XP_001234203 · ENTREZ:770883
G. gallusNCBI:XP_426515 · ENTREZ:428958
G. gallusNCBI:XP_001234209 · ENTREZ:770890
H. sapiensENSEMBL:ENSG00000107798 · UniProtKB:P38571 (IPI00007207 · LICH_HUMAN · IPI00446007 · LIPA · P38571)Lysosomal acid lipase/cholesteryl ester hydrolase⌘
H. sapiensENSEMBL:ENSG00000182333 · UniProtKB:P07098 (IPI00009893 · P07098 · LIPG_HUMAN · LIPF)Gastric triacylglycerol lipase⌘
H. sapiensENSEMBL:ENSG00000204022 · UniProtKB:Q5W064 (LIPJ_HUMAN · LIPJ · IPI00082138 · LIPL1 · Q5W064)Lipase member J⌘
H. sapiensENSEMBL:ENSG00000204021 · UniProtKB:Q5VXJ0 (LIPK_HUMAN · IPI00479714 · LIPK · LIPL2 · Q5VXJ0)Lipase member K⌘
H. sapiensENSEMBL:ENSG00000173239 · UniProtKB:Q5VYY2 (LIPM_HUMAN · Q5VYY2 · LIPL3 · IPI00307230 · LIPM)Lipase member M⌘
M. musculusNCBI:NP_001013792 · MGI:MGI:2147592
M. musculusNCBI:XP_001477977 · MGI:MGI:3779637
M. musculusNCBI:XP_999455 · MGI:MGI:3644466
M. musculusUniProtKB:Q9Z0M5 · MGI:MGI:96789 (Lip1 · Lal · Lip-1 · Lipa)lysosomal acid lipase A⌘
M. musculusUniProtKB:Q9CPP7 · MGI:MGI:1914967 (Lipf)lipase, gastric⌘
M. musculusUniProtKB:Q8BM14 · MGI:MGI:2679259 (Lipl2 · Lipk)lipase, family member K⌘
M. musculusUniProtKB:Q8K2A6 · MGI:MGI:1926003 (Lipm · Lipl3)lipase, family member M⌘
R. norvegicusNCBI:XP_001079892 · RGD:1304912
R. norvegicusNCBI:XP_001079875 · RGD:1309724
R. norvegicusRGD:3008 (Lipa) · UniProtKB:Q64194 (Lip1 · Lal · Q64194 · LICH_RAT · IPI00210038 · Lipa)lipase A, lysosomal acid, cholesterol esterase · Lysosomal acid lipase/cholesteryl ester hydrolase⌘⌘
R. norvegicusUniProtKB:P04634 · RGD:708441 (Lipf)lipase, gastric⌘
S. cerevisiaeUniProtKB:P34163 · SGD:S000001623 (YKL5 · YKL140W · TGL1)Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis⌘
S. pombeUniProtKB:O74430 · GeneDB_Spombe:SPCC1672.09 (SPCC1672.09)triglyceride lipase-cholesterol esterase⌘
S. pombeUniProtKB:P78898 · GeneDB_Spombe:SPBC16A3.12c (SPBC16A3.12c)triglyceride lipase-cholesterol esterase⌘
S. pombeUniProtKB:O60095 · GeneDB_Spombe:SPBC14C8.15 (SPBC14C8.15)triglyceride lipase-cholesterol esterase⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P34163 · SGD:S000001623+278000 WOLMAN DISEASE;;LYSOSOMAL ACID LIPASE DEFICIENCY;;LIPA DEFICIENCY;;LAL DEFICIENCY;;ACID CHOLESTERYL ESTER HYDROLASE DEFICIENCY, WOLMAN TYPE;;CHOLESTEROL ESTER HYDROLASE DEFICIENCY;;CHOLESTEROL ESTER STORAGE DISEASE; CESD;;CHOLESTERYL ESTER STORAGE DISEASE;;ACID CHOLESTERYL ESTER HYDROLASE DEFICIENCY, TYPE 2LIPASE A, LYSOSOMAL ACID, INCLUDED; LIPA, INCLUDED;;CHOLESTEROL ESTER HYDROLASE, INCLUDED
SGD Disease Papers (1)
UniProtKB:P34163 · SGD:S000001623PMID:15713625 Koffel R, et al. (2005) The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Mol Cell Biol 25(5):1655-68
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu