P-POD: Princeton Protein Orthology Database: GO3/Para849

This family has 83 members: 11 Arabidopsis thaliana, 8 Caenorhabditis elegans, 16 Danio rerio, 4 Dictyostelium discoideum, 6 Drosophila melanogaster, 7 Gallus gallus, 7 Homo sapiens, 10 Mus musculus, 10 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Para849
83 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_567492.1 · TAIR:locus:2130499 (CBL6 · FCAALL.89 · AT4G16350 · DL4205C · SCABP2)SOS3-LIKE CALCIUM BINDING PROTEIN 2 · CALCINEURIN B-LIKE PROTEIN 6⌘
A. thalianaNCBI:NP_194386.1 · TAIR:locus:2133857 (T15N24.10 · AT4G26560 · CBL7)CALCINEURIN B-LIKE 7⌘
A. thalianaNCBI:NP_200410.1 · TAIR:locus:2161760 (ATCBL2 · CBL2 · mda7.3 · AT5G55990 · mda7_3)CALCINEURIN B-LIKE 2⌘
A. thalianaNCBI:NP_176629.1 · TAIR:locus:2019439 (F1N19_5 · F1N19.5 · AT1G64480 · CBL8)CALCINEURIN B-LIKE PROTEIN 8⌘
A. thalianaNCBI:NP_566610.1 · TAIR:locus:2095052 (MYF24.29 · AT3G18430)⌘
A. thalianaNCBI:NP_192051.2 · TAIR:locus:2125162 (F3D13.2 · CBL5 · AT4G01420 · F3D13_2)CALCINEURIN B-LIKE PROTEIN 5⌘
A. thalianaNCBI:NP_849449.1 · TAIR:locus:2133867 (CBL3 · T15N24.20 · ATCBL3 · T15N24_20 · AT4G26570)ARABIDOPSIS THALIANA CALCINEURIN B-LIKE 3 · CALCINEURIN B-LIKE 3⌘
A. thalianaNCBI:NP_195026.1 · TAIR:locus:2123767 (AT4G33000 · F26P21_120 · ATCBL10 · SOS3-LIKE · F26P21.120 · SCABP8 · CBL10)CALCINEURIN B-LIKE 10⌘
A. thalianaNCBI:NP_567533.1 · TAIR:locus:2129306 (FCAALL.122 · CBL1 · SCABP5 · AT4G17615 · ATCBL1)CALCINEURIN B-LIKE PROTEIN 1 · SOS3-LIKE CALCIUM BINDING PROTEIN 5 · ARABIDOPSIS THALIANA CALCINEURIN B-LIKE PROTEIN⌘
A. thalianaNCBI:NP_199521.1 · TAIR:locus:2152012 (K14A3.5 · AT5G47100 · K14A3_5 · CBL9)⌘
A. thalianaNCBI:NP_197815.1 · TAIR:locus:2169794 (MOP9.19 · MOP9_19 · AT5G24270 · CBL4 · SOS3)SALT OVERLY SENSITIVE 3 · CALCINEURIN B-LIKE PROTEIN 4⌘
C. elegansWB:WBGene00003563 (ncs-1 · C44C1.3) · UniProtKB:P36608⌘
C. elegansWB:WBGene00019108 (F59D6.7) · UniProtKB:O16343⌘
C. elegansWB:WBGene00000554 (cnb-1 · F55C10.1) · UniProtKB:Q20804⌘
C. elegansWB:WBGene00014109 (ZK856.8) · UniProtKB:Q23643⌘
C. elegansWB:WBGene00015867 (C16H3.1) · UniProtKB:Q94172⌘
C. elegansWB:WBGene00003565 (ncs-3 · K03E6.3) · UniProtKB:Q95ZR9⌘
C. elegansWB:WBGene00022164 (Y71H2AL.1) · UniProtKB:Q9N2Y1⌘
C. elegansWB:WBGene00008998 (F21A10.1) · UniProtKB:Q9XXN7⌘
D. rerioENSEMBL:ENSDARP00000094833
D. rerioENSEMBL:ENSDARP00000052098
D. rerioENSEMBL:ENSDARP00000022350
D. rerioENSEMBL:ENSDARG00000070491 · UniProtKB:A3KPW8
D. rerioENSEMBL:ENSDARG00000041379 · UniProtKB:Q1LUM5
D. rerioUniProtKB:Q5MAC7 · ZFIN:ZDB-GENE-050120-1 (guca1g)guanylate cyclase activator 1g⌘
D. rerioZFIN:ZDB-GENE-040912-18 (zgc:92169) · UniProtKB:Q66HZ0⌘
D. rerioUniProtKB:Q6AXL4 · ZFIN:ZDB-GENE-040808-37 (ncald)neurocalcin delta⌘
D. rerioZFIN:ZDB-GENE-040426-1683 (hippocalcin · hpca) · UniProtKB:Q6PC34⌘
D. rerioUniProtKB:Q6ZM98 · ZFIN:ZDB-GENE-040724-231 (guca1d)guanylate cyclase activator 1d⌘
D. rerioZFIN:ZDB-GENE-040426-1242 (zgc:63695) · UniProtKB:Q7SXX4⌘
D. rerioUniProtKB:Q7T2F7 · ZFIN:ZDB-GENE-030131-4086 (zgc:63904)⌘
D. rerioZFIN:ZDB-GENE-030131-5810 (zgc:55363) · UniProtKB:Q803Y0⌘
D. rerioUniProtKB:Q53A16 · ZFIN:ZDB-GENE-050930-1 (freqb)frequenin homolog b (Drosophila)⌘
D. rerioUniProtKB:Q6PFM5 · ZFIN:ZDB-GENE-040426-1577 (guca1e)guanylate cyclase activator 1e⌘
D. rerioUniProtKB:Q804C0 · ZFIN:ZDB-GENE-021220-1 (freqa)frequenin homolog a (Drosophila)⌘
D. discoideumUniProtKB:Q55G87 · dictyBase:DDB_G0267446 (CNB · cnbA)protein phosphatase 2B, protein serine/threonine phosphatase, CaM-dependent protein phosphatase, regulatory subunit, calcineurin B⌘
D. discoideumUniProtKB:Q54MF3 · dictyBase:DDB_G0285999 (cnbB)putative CaM-dependent protein phosphatase, regulatory subunit, putative calcineurin B, calcium-binding EF-hand domain-containing protein⌘
D. discoideumUniProtKB:Q75K28 · dictyBase:DDB_G0275931 (ncsA)calcium-binding protein, NCS-1/frequenin-related protein⌘
D. discoideumUniProtKB:Q86A72 · dictyBase:DDB_G0274781 (DDB_G0274781)calcium-binding protein, S100/CaBP-9k-type calcium-binding domain-containing protein, recoverin family protein, NCS-1/frequenin-related protein⌘
D. melanogasterUniProtKB:Q24214 · FB:FBgn0015614 (dCnB2 · CS2-1 · dCNB2 · CanB2 · canB2 · CG11217)calcineurin B2 · Calcineurin suppressor, chromosome 2, group 1 · Calcineurin B2⌘
D. melanogasterUniProtKB:Q24214 · FB:FBgn0010014 (CNB · CanB · Can · BcDNA:RH11383 · dCnB1 · canB-4F · CG4209)Calcineurin B⌘
D. melanogasterUniProtKB:P37236 · FB:FBgn0030897 (frequenin · frq1 · Frequinin · Frq · HL-II · Frq1 · CG5744 · Frequenin)Frequenin 1⌘
D. melanogasterFB:FBgn0013303 (neurocalcin · nca · CG7641 · Ncalc · Nca · Neurocalcin) · UniProtKB:P42325⌘
D. melanogasterUniProtKB:Q7K107 · FB:FBgn0037358 (CG2185 · elm)ethanol sensitive with low memory⌘
D. melanogasterUniProtKB:Q9VWX8 · FB:FBgn0083228 (CG5907 · frq2 · Frq2 · Frq)Frequenin 2⌘
G. gallusNCBI:XP_417823 · ENTREZ:419676
G. gallusNCBI:XP_001233529 · ENTREZ:419668
G. gallusENTREZ:423211 · UniProtKB:Q5ZM44 (RCJMB04_3d7 · IPI00580709 · CHP1_CHICK · CHP · Q5ZM44)Calcium-binding protein p22⌘
G. gallusENTREZ:396161 · UniProtKB:P42324 (REM1 · HPCL1_CHICK · P42324 · IPI00574725 · HPCAL1)Hippocalcin-like protein 1⌘
G. gallusUniProtKB:P62758 (IPI00594739 · P62758 · NCALD_CHICK · NCALD · Neurocalcin-delta) · ENTREZ:396048⌘
G. gallusENTREZ:396336 · UniProtKB:P62167 (NCS1_CHICK · FLUP · P62167 · IPI00586670 · NCS1 · FREQ)Neuronal calcium sensor 1⌘
G. gallusUniProtKB:Q6VN51 (Q6VN51 · IPI00600396 · RCJMB04_23k16) · ENTREZ:378804⌘
H. sapiensENSEMBL:ENSG00000188386 · UniProtKB:Q96LZ3 (PPP3R2 · CBLP · CANB2_HUMAN · IPI00065432 · Q96LZ3)Calcineurin subunit B type 2⌘
H. sapiensENSEMBL:ENSG00000187446 · UniProtKB:Q99653 (CHP1_HUMAN · IPI00218924 · Q99653 · CHP)Calcium-binding protein p22⌘
H. sapiensENSEMBL:ENSG00000121905 · UniProtKB:P84074 (BDR2 · HPCA · HPCA_HUMAN · IPI00219103 · P84074)Neuron-specific calcium-binding protein hippocalcin⌘
H. sapiensENSEMBL:ENSG00000115756 · UniProtKB:P37235 (BDR1 · HPCL1_HUMAN · IPI00219344 · P37235 · HPCAL1)Hippocalcin-like protein 1⌘
H. sapiensENSEMBL:ENSG00000116983 · UniProtKB:Q9UM19 (HPCAL4 · HPCL4_HUMAN · IPI00008305 · Q9UM19)Hippocalcin-like protein 4⌘
H. sapiensENSEMBL:ENSG00000104490 · UniProtKB:P61601 (NCALD · NCALD_HUMAN · IPI00395510 · Neurocalcin-delta · P61601)⌘
H. sapiensENSEMBL:ENSG00000107130 · UniProtKB:P62166 (IPI00219110 · NCS1_HUMAN · FLUP · P62166 · NCS1 · FREQ)Neuronal calcium sensor 1⌘
M. musculusNCBI:XP_001479159 · MGI:MGI:3644230
M. musculusNCBI:XP_001479027 · MGI:MGI:3645836
M. musculusUniProtKB:Q63810 · MGI:MGI:107172 (Ppp3r1 · Cnb1)protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) · PP2B beta 1⌘
M. musculusUniProtKB:Q63811 · MGI:MGI:107171 (Ppp3r2)protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) · PP2B beta 2⌘
M. musculusUniProtKB:P61022 · MGI:MGI:1927185 (Sid470p · 1500003O03Rik)RIKEN cDNA 1500003O03 gene⌘
M. musculusMGI:MGI:1336200 (hippocalcin · Hpca) · UniProtKB:P84075⌘
M. musculusUniProtKB:P62748 · MGI:MGI:1855689 (VILIP3 · Nvp3 · Vnsl3 · Hpcal1)hippocalcin-like 1 · neural visinin-like 3 · visinin like 3⌘
M. musculusUniProtKB:Q8BGZ1 · MGI:MGI:2157521 (Hpcal4)hippocalcin-like 4⌘
M. musculusUniProtKB:Q91X97 · MGI:MGI:1196326 (Ncald · D15Ertd412e)neurocalcin delta⌘
M. musculusUniProtKB:Q8BNY6 · MGI:MGI:109166 (Freq · NCS-1)frequenin homolog (Drosophila)⌘
R. norvegicusNCBI:XP_575321 · RGD:1565588 (RGD1565588)similar to calcium binding protein P22⌘
R. norvegicusNCBI:XP_575825 · RGD:1564956
R. norvegicusRGD:69230 (Ppp3r1) · UniProtKB:P63100 (Cna2 · P63100 · Ppp3r1 · Cnb · CANB1_RAT · IPI00230947 · IPI00206406)protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) · Calcineurin subunit B type 1⌘⌘
R. norvegicusUniProtKB:P28470 · RGD:69232 (Ppp3r2)protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)⌘
R. norvegicusUniProtKB:P61023 · RGD:620447 (Chp)calcium binding protein p22⌘
R. norvegicusRGD:620060 (hippocalcin · Hpca) · UniProtKB:P84076⌘
R. norvegicusUniProtKB:P62749 · RGD:708375 (Hpcal1)hippocalcin-like 1⌘
R. norvegicusUniProtKB:P35332 · RGD:708491 (Hpcal4)hippocalcin-like 4⌘
R. norvegicusUniProtKB:Q5PQN0 · RGD:1560287 (Ncald)neurocalcin delta⌘
R. norvegicusUniProtKB:P62168 · RGD:68417 (Freq)frequenin homolog (Drosophila)⌘
S. cerevisiaeUniProtKB:P25296 · SGD:S000001673 (CRV1 · CNB1 · YCN2 · YKL190W)Calcineurin B⌘
S. cerevisiaeUniProtKB:Q06389 · SGD:S000002781 (YDR373W · FRQ1)N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p⌘
S. pombeUniProtKB:Q9UU93 · GeneDB_Spombe:SPCC830.06 (SPCC830.06)calcineurin regulatory subunit⌘
S. pombeUniProtKB:Q09711 · GeneDB_Spombe:SPAC18B11.04 (ncs1 · SPAC18B11.04)related to neuronal calcium sensor Ncs1⌘
ProteinPublicationCurator Notes
UniProtKB:P25296 · SGD:S000001673PMID:9238019 Liang F, et al. ECA1 complements yeast mutants defective in Ca2+ pumps and encodes an endoplasmic reticulum-type Ca2+-ATPase in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8579-84.The A. thaliana protein AT1G07810.1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that A. thaliana AT1G07810.1 suppresses the phenotype associated with the yeast triple mutant (pmr1 pmc1 cnb 1) which is deficient in Golgi and vacuolar Ca(2+) pumps and calcineurin B.
UniProtKB:P25296 · SGD:S000001673PMID:9808725 Liang F, et al. A high-affinity Ca2+ pump, ECA1, from the endoplasmic reticulum is inhibited by cyclopiazonic acid but not by thapsigargin. Plant Physiol. 1998 Nov;118(3):817-25.The A. thaliana protein AT1G07810.1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows A. thaliana ECA1 (AT1G07810.1) is a Ca2+-ATPase homolog that complements a yeast pmc1 pmr1 cnb1 triple mutant, deficient in Ca(2+) pumps, indicating that ECA1 encodes a functional Ca2+-ATPase. The triple mutant includes cnb1 which encodes the protein phosphatase calcineurin B, but the triple mutant was used to test for Ca2+-pump activity, not protein phosphatase activity.
UniProtKB:P25296 · SGD:S000001673PMID:8662738 Lippuner V, et al. Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast. J Biol Chem. 1996 May 31;271(22):12859-66.The A. thaliana protein At1g27730.1 was expressed in S. cerevisiae, but complementation was not directly tested. Arabidopsis At1g27730.1 suppresses the salt-sensitive phenotype of yeast calcineurin cnb1 mutants.
UniProtKB:P25296 · SGD:S000001673PMID:16244156 Park S, et al. Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters. Plant Physiol. 2005 Nov;139(3):1194-206.The A. thaliana protein AT2G38170.3 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that a modified form of CAX1 (AT2G38170.3) suppresses a yeast pmc1 cnb vcx1 triple mutant deficient in vacuolar Ca2+ transporters and lacking functional calcineurin.
UniProtKB:P25296 · SGD:S000001673PMID:10200328 Kudla J, et al. Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4718-23.The A. thaliana protein AT4G17615.1 complements a homologous mutation in S. cerevisiae. This paper shows that interaction of A. thaliana AtCBL1 (AT4G17615.1) and rat calcineurin A complements the salt-sensitive phenotype in a yeast calcineurin B cnb1 mutant. Because AtCBL1 alone did not complement the yeast cnb1 mutant (SMY3 strain), the authors speculate that AtCBL1 may not efficiently interact with yeast CNA1.
UniProtKB:P25296 · SGD:S000001673PMID:9689141 Pardo JM, et al. Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9681-6.The S. cerevisiae protein CNB1 was expressed in N. tabacum, but complementation was not directly tested.
UniProtKB:Q06389 · SGD:S000002781PMID:14512421 Strahl T, et al. Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1. J Biol Chem. 2003 Dec 5;278(49):49589-99.The H. sapiens protein P62166 complements a homologous mutation in S. cerevisiae.
UniProtKB:P25296 · SGD:S000001673PMID:10948258 Chung WS, et al. Identification of a calmodulin-regulated soybean Ca(2+)-ATPase (SCA1) that is located in the plasma membrane. Plant Cell. 2000 Aug;12(8):1393-407.The G. max protein SCA1 was expressed in S. cerevisiae, but complementation was not directly tested. This papers shows that soybean SCA1 (Q9FVE8_SOYBN) encodes a Ca(2+)-ATPase and complements complements a yeast pmc1 pmr1 cnb1 triple mutant, deficient in Ca(2+) pumps, indicating that ECA1 encodes a functional Ca2+-ATPase. The triple mutant includes cnb1 which encodes the protein phosphatase calcineurin B, but the triple mutant was used to test for Ca2+-pump activity, not protein phosphatase activity.
UniProtKB:P25296 · SGD:S000001673PMID:16244156 Park S, et al. Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters. Plant Physiol. 2005 Nov;139(3):1194-206.The A. thaliana protein AT5G01490.1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that a modified form of CAX4 (AT5G01490.1) suppresses a yeast pmc1 cnb vcx1 triple mutant deficient in vacuolar Ca2+ transporters and lacking functional calcineurin.
UniProtKB:Q06389 · SGD:S000002781PMID:14512421 Strahl T, et al. Conservation of regulatory function in calcium-binding proteins: human frequenin (neuronal calcium sensor-1) associates productively with yeast phosphatidylinositol 4-kinase isoform, Pik1. J Biol Chem. 2003 Dec 5;278(49):49589-99.The H. sapiens protein NCS1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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