P-POD: Princeton Protein Orthology Database: GO3/Para828

This family has 61 members: 11 Arabidopsis thaliana, 3 Caenorhabditis elegans, 9 Danio rerio, 1 Dictyostelium discoideum, 4 Drosophila melanogaster, 1 Escherichia coli, 6 Gallus gallus, 7 Homo sapiens, 8 Mus musculus, 7 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

61 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2081378 (F26G5.60 · ATJ3 · ATJ · AT3G44110) · NCBI:NP_189997.1⌘
A. thalianaNCBI:NP_190377.1 · TAIR:locus:2097880 (T17F15.190 · AT3G47940)⌘
A. thalianaNCBI:NP_172506.1 · TAIR:locus:2012743 (F14N23.23 · F14N23_23 · AT1G10350)⌘
A. thalianaNCBI:NP_197935.1 · TAIR:locus:2179429 (T14C9_70 · T14C9.70 · AT5G25530)⌘
A. thalianaNCBI:NP_195759.1 · TAIR:locus:2179127 (T10O8_100 · T10O8.100 · AT5G01390)⌘
A. thalianaNCBI:NP_176181.1 · TAIR:locus:2825170 (F23H11.4 · AT1G59725 · F23H11_4)⌘
A. thalianaNCBI:NP_568412.1 · TAIR:locus:505006628 (ATJ2 · AT5G22060)⌘
A. thalianaNCBI:NP_179646.1 · TAIR:locus:2054809 (T13C7.15 · AT2G20560 · T13C7_15)⌘
A. thalianaNCBI:NP_179645.1 · TAIR:locus:2054799 (T13C7.14 · T13C7_14 · AT2G20550)⌘
A. thalianaNCBI:NP_187503.1 · TAIR:locus:2097638 (AT3G08910 · T16O11.15)⌘
A. thalianaNCBI:NP_194577.1 · TAIR:locus:2121368 (F20O9.160 · F20O9_160 · AT4G28480)⌘
C. elegansWB:WBGene00001037 (T05C3.5 · dnj-19) · UniProtKB:O16303⌘
C. elegansWB:WBGene00001030 (F39B2.10 · dnj-12) · UniProtKB:O45502⌘
C. elegansWB:WBGene00001031 (F54D5.8 · dnj-13) · UniProtKB:Q20774⌘
D. rerioENSEMBL:ENSDARP00000067931
D. rerioENSEMBL:ENSDARP00000088330
D. rerioUniProtKB:Q568I8 · ZFIN:ZDB-GENE-040910-4 (dnajb13)DnaJ (Hsp40) related, subfamily B, member 13⌘
D. rerioZFIN:ZDB-GENE-040801-192 (zgc:91922) · UniProtKB:Q6DEF3⌘
D. rerioUniProtKB:Q6DEJ4 · ZFIN:ZDB-GENE-040801-90 (dnajb1)DnaJ (Hsp40) homolog, subfamily B, member 1⌘
D. rerioUniProtKB:Q7ZVS0 · ZFIN:ZDB-GENE-030131-2884 (dnaja2l)DnaJ (Hsp40) homolog, subfamily A, member 2, like⌘
D. rerioZFIN:ZDB-GENE-030131-5455 (zgc:55492) · UniProtKB:Q7ZVY8⌘
D. rerioUniProtKB:Q803K1 · ZFIN:ZDB-GENE-030131-2642 (dnaja1l)DnaJ (Hsp40) homolog, subfamily A, member 1, like⌘
D. rerioUniProtKB:Q7ZUP5 · ZFIN:ZDB-GENE-040426-2884 (dnaja2)DnaJ (Hsp40) homolog, subfamily A, member 2⌘
D. discoideumUniProtKB:Q54VQ1 · dictyBase:DDB_G0280037 (ddj1)heat shock protein⌘
D. melanogasterUniProtKB:Q24133 · FB:FBgn0015657 (anon-WO0140519.166 · CG10578 · DroJ1 · DnaJ-like-1 · anon-WO0172774.135 · dHDJ1 · dHdj1 · DROJ1 · droj1 · HSP40/HDJ1 · DnaJ-1 · HSP40 · dHDJ1/HSP40 · Hsp40 · dhdJ1 · EU3500 · DNAJ1 · dhdj-1 · Hsp-40)dnaJ like1 · DnaJ1 64EF⌘
D. melanogasterFB:FBgn0038145 (DnaJ-like-2 · CG8863 · Droj2 · anon-WO0118547.404) · UniProtKB:Q9VFV9⌘
D. melanogasterFB:FBgn0031322 (CG5001) · UniProtKB:Q9VPY9⌘
D. melanogasterFB:FBgn0030207 (CG2887) · UniProtKB:Q9W2U5⌘
E. coliUniProtKB:P36659 · ECOLI:EG12193-MONOMER (ECK0991 · cbpA · CbpA · b1000)CbpA monomer⌘
G. gallusNCBI:XP_424983 · ENTREZ:427409
G. gallusNCBI:XP_001233254 · ENTREZ:424550
G. gallusNCBI:XP_417251 · ENTREZ:419060
G. gallusNCBI:XP_413746 · ENTREZ:415360
G. gallusUniProtKB:Q5ZIZ7 (Q5ZIZ7 · RCJMB04_22f12 · IPI00573759) · ENTREZ:415744⌘
G. gallusUniProtKB:Q5ZJV3 (RCJMB04_15h2 · IPI00598722 · Q5ZJV3) · ENTREZ:427376⌘
H. sapiensENSEMBL:ENSG00000187726 · UniProtKB:P59910 (TSARG6 · P59910 · IPI00374263 · DNAJB13 · DJB13_HUMAN · IPI00374262 · TSARG3)DnaJ homolog subfamily B member 13⌘
H. sapiensENSEMBL:ENSG00000086061 · UniProtKB:P31689 (HSJ2 · DNAJA1 · HSPF4 · P31689 · IPI00012535 · HDJ2 · DNAJ2 · DNJA1_HUMAN)DnaJ homolog subfamily A member 1⌘
H. sapiensENSEMBL:ENSG00000069345 · UniProtKB:O60884 (DNAJA2 · IPI00032406 · CPR3 · HIRIP4 · O60884 · DNJA2_HUMAN)DnaJ homolog subfamily A member 2⌘
H. sapiensENSEMBL:ENSG00000140403 · UniProtKB:Q8WW22 (DNJA4_HUMAN · IPI00853174 · Q8WW22 · DNAJA4)DnaJ homolog subfamily A member 4⌘
H. sapiensENSEMBL:ENSG00000132002 · UniProtKB:P25685 (DNAJ1 · DNAJB1 · HDJ1 · DNJB1_HUMAN · P25685 · HSPF1 · IPI00015947)DnaJ homolog subfamily B member 1⌘
H. sapiensENSEMBL:ENSG00000162616 · UniProtKB:Q9UDY4 (IPI00003848 · HLJ1 · DNAJB4 · DNAJW · Q9UDY4 · DNJB4_HUMAN)DnaJ homolog subfamily B member 4⌘
H. sapiensENSEMBL:ENSG00000137094 · UniProtKB:O75953 (DNJB5_HUMAN · HSC40 · IPI00871830 · O75953 · DNAJB5 · IPI00016855)DnaJ homolog subfamily B member 5⌘
M. musculusNCBI:XP_984887 · MGI:MGI:3646286
M. musculusUniProtKB:Q80Y75 · MGI:MGI:1916637 (Dnajb13)DnaJ (Hsp40) related, subfamily B, member 13⌘
M. musculusUniProtKB:P63037 · MGI:MGI:1270129 (Hsj2 · Dnaja1 · Nedd7)DnaJ (Hsp40) homolog, subfamily A, member 1⌘
M. musculusUniProtKB:Q9QYJ0 · MGI:MGI:1931882 (Dnaja2 · PRO3015 · mDj3 · HIRIP4 · DNJ3)DnaJ (Hsp40) homolog, subfamily A, member 2⌘
M. musculusUniProtKB:Q9JMC3 · MGI:MGI:1927638 (Hsj4 · Dj4 · Dnaja4)DnaJ (Hsp40) homolog, subfamily A, member 4⌘
M. musculusUniProtKB:Q9QYJ3 · MGI:MGI:1931874 (Hsp40 · Dnajb1)DnaJ (Hsp40) homolog, subfamily B, member 1⌘
M. musculusUniProtKB:Q9D832 · MGI:MGI:1914285 (Dnajb4)DnaJ (Hsp40) homolog, subfamily B, member 4⌘
M. musculusUniProtKB:O89114 · MGI:MGI:1930018 (Hsp40-3 · Dnajb5 · Hsc40)DnaJ (Hsp40) homolog, subfamily B, member 5⌘
R. norvegicusNCBI:XP_001069407 · RGD:1304725 (Dnajb1)DnaJ (Hsp40) homolog, subfamily B, member 1⌘
R. norvegicusNCBI:XP_233767 · RGD:1307453 (Dnajb5)DnaJ (Hsp40) homolog, subfamily B, member 5⌘
R. norvegicusUniProtKB:P63036 · RGD:620942 (Dnaja1)DnaJ (Hsp40) homolog, subfamily A, member 1⌘
R. norvegicusRGD:71001 (Dnaja2) · UniProtKB:O35824 (Dnaja2 · IPI00213062 · O35824 · DNJA2_RAT)DnaJ (Hsp40) homolog, subfamily A, member 2 · DnaJ homolog subfamily A member 2⌘⌘
R. norvegicusUniProtKB:Q4QR73 · RGD:1310035 (Dnaja4)DnaJ (Hsp40) homolog, subfamily A, member 4⌘
R. norvegicusUniProtKB:Q5XIP0 · RGD:1305826 (Dnajb4)DnaJ (Hsp40) homolog, subfamily B, member 4⌘
R. norvegicusUniProtKB:Q5YKV6 · RGD:1359131 (Dnajb13)DnaJ (Hsp40) related, subfamily B, member 13⌘
S. cerevisiaeUniProtKB:P25491 · SGD:S000005008 (YNL064C · MAS5 · YDJ1 · HSP40)Protein chaperone involved in regulation of the HSP90 and HSP70 functions⌘
S. cerevisiaeUniProtKB:P25294 · SGD:S000004952 (SIS1 · YNL007C)Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p⌘
S. pombeUniProtKB:O74752 · GeneDB_Spombe:SPBC1734.11 (SPBC1734.11)DNAJ domain protein Mas5⌘
S. pombeUniProtKB:Q09912 · GeneDB_Spombe:SPCC830.07c (SPCC830.07c · psi1 · psi)DNAJ domain protein Psi1⌘
ProteinPublicationCurator Notes
UniProtKB:P25491 · SGD:S000005008PMID:11939789 Yan W, et al. Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function. Biochemistry. 2002 Apr 16;41(15):4938-45.The H. sapiens/S. cerevisiae protein Q13217 complements a homologous mutation in S. cerevisiae. A chimeric protein in which the human p58IPK J domain replaces the yeast Ydj1p J domain can complement a yeast ydj1 mutant.
UniProtKB:P25294 · SGD:S000004952PMID:11551903 Salmon D, et al. A DnaJ-like protein homologous to the yeast co-chaperone Sis1 (TcJ6p) is involved in initiation of translation in Trypanosoma cruzi. J Biol Chem. 2001 Nov 23;276(47):43970-9.The T. cruzi protein TcJ6 complements a homologous mutation in S. cerevisiae.
UniProtKB:P25294 · SGD:S000004952PMID:10677504 Krobitsch S, et al. Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1589-94.The H. sapiens protein Ht (protein ID unknown) was expressed in S. cerevisiae, but complementation was not directly tested. This paper describes the characterization of variant truncated forms of the human Huntington's disease protein expressed in yeast.
UniProtKB:P25491 · SGD:S000005008PMID:9605323 Leng CH, et al. Isolation and characterization of a DnaJ-like protein in rats: the C-terminal 10-kDa domain of hsc70 is not essential for stimulating the ATP-hydrolytic activity of hsc70 by a DnaJ-like protein. Protein Sci. 1998 May;7(5):1186-94.The R. norvegicus protein RDJ1 complements a homologous mutation in S. cerevisiae. Rat RDJ1 rescues the temperature-sensitive lethality of a yeast ydj1-151 mutant.
UniProtKB:P25491 · SGD:S000005008PMID:15147737 Edkins AL, et al. A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40. Int J Biochem Cell Biol. 2004 Aug;36(8):1585-98.The T. cruzi protein Tcj2 complements a homologous mutation in S. cerevisiae.
UniProtKB:P25491 · SGD:S000005008PMID:16889384 Zhang W, et al. Enhanced secretion of heterologous proteins in Pichia pastoris following overexpression of Saccharomyces cerevisiae chaperone proteins. Biotechnol Prog. 2006 Jul-Aug;22(4):1090-5.The S. cerevisiae protein YDJ1 was expressed in P. pastoris, but complementation was not directly tested. This paper shows heterologous overexpression of S. cerevisiae YDJ1 in P. pastoris.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:P25491 · SGD:S000005008PMID:10859365 Muchowski PJ, et al. (2000) Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc Natl Acad Sci U S A 97(14):7841-6
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