P-POD: Princeton Protein Orthology Database: GO3/Para640

This family has 58 members: 8 Arabidopsis thaliana, 4 Caenorhabditis elegans, 5 Danio rerio, 4 Dictyostelium discoideum, 4 Drosophila melanogaster, 2 Escherichia coli, 6 Gallus gallus, 7 Homo sapiens, 6 Mus musculus, 5 Rattus norvegicus, 3 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.

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GO3/Para640
58 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2041213 (F14M13_20 · AT2G22400 · F14M13.20) · NCBI:NP_850024.1⌘
A. thalianaNCBI:NP_851079.1 · TAIR:locus:2179749 (T19G15_30 · T19G15.30 · AT5G26180)⌘
A. thalianaNCBI:NP_201419.2 · TAIR:locus:2156902 (K2A18_26 · AT5G66180 · K2A18.26)⌘
A. thalianaNCBI:NP_194390.2 · TAIR:locus:2133832 (T15N24.50 · AT4G26600 · T15N24_50)⌘
A. thalianaNCBI:NP_195710.3 · TAIR:locus:2140094 (T5J17_170 · T5J17.170 · AT4G40000)⌘
A. thalianaNCBI:NP_850927.1 · TAIR:locus:2178393 (AT5G55920)⌘
A. thalianaNCBI:NP_187924.2 · TAIR:locus:2090054
A. thalianaNCBI:NP_172143.3 · TAIR:locus:2009170 (F12K11_10 · F12K11.10 · AT1G06560)⌘
C. elegansWB:WBGene00021476 · UniProtKB:Q95XR2
C. elegansWB:WBGene00021686 (Y48G8AL.5) · UniProtKB:Q9BL15⌘
C. elegansWB:WBGene00013151 · UniProtKB:Q9NAA7
C. elegansWB:WBGene00021073 (nol-1 · W07E6.1) · UniProtKB:Q9TYV5⌘
D. rerioZFIN:ZDB-GENE-050706-95 (zgc:109983) · UniProtKB:Q4KMK0⌘
D. rerioZFIN:ZDB-GENE-050309-7 (si:dkey-91i17.1) · UniProtKB:A4IGA8⌘
D. rerioUniProtKB:Q5PRB6 · ZFIN:ZDB-GENE-041212-77 (nsun4)NOL1/NOP2/Sun domain family, member 4⌘
D. rerioZFIN:ZDB-GENE-040426-2476 (zgc:77183) · UniProtKB:Q7SXM8⌘
D. rerioUniProtKB:A5PMI3 · ZFIN:ZDB-GENE-030131-4017 (nsun2)NOL1/NOP2/Sun domain family, member 2⌘
D. discoideumUniProtKB:Q54FX0 · dictyBase:DDB_G0290553 (DDB_G0290553)PUA domain-containing protein, NOL1/NOP2/Sun family protein⌘
D. discoideumUniProtKB:Q54TL4 · dictyBase:DDB_G0281685 (nol1)NOL1/NOP2/Sun family protein⌘
D. discoideumdictyBase:DDB_G0269676 · UniProtKB:Q55DF6
D. discoideumUniProtKB:Q55G09 · dictyBase:DDB_G0267872 (DDB_G0267872)NOL1/NOP2/Sun family protein⌘
D. melanogasterFB:FBgn0026079 (CG6133 · EG:EG0007.9) · UniProtKB:Q9W4M9⌘
D. melanogasterFB:FBgn0037200 (CT31087 · CG11109) · UniProtKB:Q8IPS4⌘
D. melanogasterFB:FBgn0038684 · UniProtKB:Q9VDZ4
D. melanogasterFB:FBgn0031308 · UniProtKB:Q9VPX3
E. coliUniProtKB:P36929 · ECOLI:EG12163-MONOMER (fmu · rrmB · b3289 · RsmB · sun · fmv · rsmB · ECK3275 · yhdB)16S rRNA m5C967 methyltransferase⌘
E. coliUniProtKB:P76273 · ECOLI:G7008-MONOMER (ECK1834 · b1835 · yebU · rsmF · RsmF)16S rRNA m5C1407 methyltransferase⌘
G. gallusNCBI:XP_422449 · ENTREZ:424613
G. gallusNCBI:XP_425980 · ENTREZ:428419
G. gallusNCBI:XP_416502 · ENTREZ:418277
G. gallusNCBI:XP_415710 · ENTREZ:417462
G. gallusNCBI:XP_416643 · ENTREZ:418432
G. gallusENTREZ:420938 · UniProtKB:Q5ZLV4 (RCJMB04_4l11 · IPI00594887 · NSUN2 · Q5ZLV4 · NSUN2_CHICK)tRNA (cytosine-5-)-methyltransferase NSUN2⌘
H. sapiensENSEMBL:ENSG00000111641 · UniProtKB:P46087 (NOL1 · NOP2 · IPI00872909 · NOP2_HUMAN · P46087 · IPI00654555)Putative ribosomal RNA methyltransferase NOP2⌘
H. sapiensENSEMBL:ENSG00000106133 · UniProtKB:Q63ZY6 (WBSCR20B · IPI00807665 · IPI00807520 · Q63ZY6 · IPI00470560 · WBSCR20C · NSUN5C · NSN5C_HUMAN · IPI00167075 · IPI00807349 · IPI00807644)Putative methyltransferase NSUN5C⌘
H. sapiensENSEMBL:ENSG00000037474 · UniProtKB:Q08J23 (IPI00306369 · Q08J23 · NSUN2_HUMAN · TRM4 · SAKI · NSUN2)tRNA (cytosine-5-)-methyltransferase NSUN2⌘
H. sapiensENSEMBL:ENSG00000178694 · UniProtKB:Q9H649 (MSTP077 · IPI00004969 · UG0651E06 · NSUN3 · NSUN3_HUMAN · Q9H649)Putative methyltransferase NSUN3⌘
H. sapiensENSEMBL:ENSG00000117481 · UniProtKB:Q96CB9 (IPI00847475 · NSUN4_HUMAN · IPI00847563 · Q96CB9 · NSUN4 · IPI00303944)Putative methyltransferase NSUN4⌘
H. sapiensENSEMBL:ENSG00000130305 · UniProtKB:Q96P11 (NSUN5 · Q96P11 · IPI00101659 · NSUN5_HUMAN · WBSCR20 · IPI00164154 · IPI00807684 · WBSCR20A)Putative methyltransferase NSUN5⌘
H. sapiensENSEMBL:ENSG00000152487 · UniProtKB:Q8TEA1 (NSUN6 · Q8TEA1 · NOPD1 · NSUN6_HUMAN · IPI00152688)Putative methyltransferase NSUN6⌘
M. musculusUniProtKB:Q922K7 · MGI:MGI:107891 (Nol1 · Nop2 · 120kDa)NOP2 nucleolar protein homolog (yeast)⌘
M. musculusUniProtKB:Q1HFZ0 · MGI:MGI:107252 (Misu · Nsun2)NOL1/NOP2/Sun domain family member 2⌘
M. musculusUniProtKB:Q8CCT7 · MGI:MGI:2146565 (Nsun3)NOL1/NOP2/Sun domain family member 3⌘
M. musculusUniProtKB:Q9CZ57 · MGI:MGI:1919431 (Nsun4)NOL1/NOP2/Sun domain family, member 4⌘
M. musculusUniProtKB:Q8K4F6 · MGI:MGI:2140844 (Nol1r · Wbscr20a · Nsun5)NOL1/NOP2/Sun domain family, member 5⌘
M. musculusUniProtKB:Q7TS68 · MGI:MGI:1921705 (NOPD1 · Nsun6)NOL1/NOP2/Sun domain family member 6⌘
R. norvegicusNCBI:XP_221586 · RGD:1565808
R. norvegicusNCBI:XP_577176 · RGD:1565625
R. norvegicusNCBI:XP_001072946 · RGD:1309535 (Nsun6)NOL1/NOP2/Sun domain family, member 6⌘
R. norvegicusNCBI:XP_238407 · RGD:1559652
R. norvegicusNCBI:XP_001065060 · RGD:1304616 (Nol1)nucleolar protein 1⌘
S. cerevisiaeUniProtKB:P38205 · SGD:S000000120 (TRM4 · NCL1 · YBL024W)S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs⌘
S. cerevisiaeUniProtKB:P40991 · SGD:S000005005 (NOP2 · YNL061W · YNA1)Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis⌘
S. cerevisiaeUniProtKB:P53972 · SGD:S000004967 (YNL022C)Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W⌘
S. pombeGeneDB_Spombe:SPAC17D4.04 (SPAC17D4.04 · SPAC458.01 · tRNA) · UniProtKB:Q9HGQ2⌘
S. pombeUniProtKB:O94268 · GeneDB_Spombe:SPBP8B7.20c (SPBP8B7.20c)RNA methyltransferase Nop2⌘
S. pombeUniProtKB:O14039 · GeneDB_Spombe:SPAC2C4.06c (SPAC2C4.06c)rRNA methyltransferase⌘
S. pombeGeneDB_Spombe:SPAC23C4.17 (SPAC23C4.17 · tRNA) · UniProtKB:O13935⌘
ProteinPublicationCurator Notes
UniProtKB:P38205 · SGD:S000000120PMID:17071714 Brzezicha B, et al. Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). Nucleic Acids Res. 2006;34(20):6034-43.The H. sapiens protein NSUN2 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (2)
UniProtKB:P40991 · SGD:S000005005PMID:9767141 Wu P, et al. (1998) NCL1, a novel gene for a non-essential nuclear protein in Saccharomyces cerevisiae. Gene 220(1-2):109-17
UniProtKB:P40991 · SGD:S000005005PMID:9854021 King M, et al. (1999) A conserved motif in the yeast nucleolar protein Nop2p contains an essential cysteine residue. Biochem J 337 ( Pt 1):29-35
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