P-POD: Princeton Protein Orthology Database: GO3/Para509

This family has 39 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 7 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 6 Gallus gallus, 5 Homo sapiens, 5 Mus musculus, 5 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Para509
39 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_566769.1 · TAIR:locus:2094528 (AT3G25540 · MWL2.19 · LAG1)LAG1 HOMOLOG 1⌘
A. thalianaNCBI:NP_188557.1 · TAIR:locus:2094133 (MVI11.18 · LOH2 · AT3G19260)LAG1 HOMOLOG 2 · LAG ONE HOMOLOGUE 2 · LONGEVITY ASSURANCE GENE1 HOMOLOG 2⌘
A. thalianaNCBI:NP_001031037.1 · TAIR:locus:2010022 (F13B4_7 · LAG13 · AT1G13580 · F13B4.7)LAG1 LONGEVITY ASSURANCE HOMOLOG 3⌘
C. elegansWB:WBGene00002044 (hyl-2 · K02G10.6) · UniProtKB:Q7Z139⌘
C. elegansWB:WBGene00002043 (hyl-1 · C09G4.1) · UniProtKB:Q9GYR9⌘
D. rerioENSEMBL:ENSDARP00000033512
D. rerioENSEMBL:ENSDARP00000052791
D. rerioENSEMBL:ENSDARP00000070109
D. rerioENSEMBL:ENSDARP00000076418
D. rerioUniProtKB:Q1L8N1 · ZFIN:ZDB-GENE-020808-1 (trh1)trh1 protein⌘
D. rerioUniProtKB:Q7T3F1 · ZFIN:ZDB-GENE-030131-1740 (lass5)LAG1 homolog, ceramide synthase 5 (S. cerevisiae)⌘
D. rerioUniProtKB:Q90YY7 · ZFIN:ZDB-GENE-020808-2 (lass2)LAG1 homolog, ceramide synthase 2 (S. cerevisiae)⌘
D. discoideumUniProtKB:Q54S87 · dictyBase:DDB_G0282607 (crsA)sphingosine N-acyltransferase, dihydroxyceramide synthase, ceramide synthase⌘
D. melanogasterUniProtKB:Q9W423 · FB:FBgn0040918 (l(1)G0489 · longevity · CG15898 · l(1)G0365 · Lag1 · DLAG1 · Dlag1 · CG3576 · lon · l(1)G0061)Longevity assurance gene 1⌘
G. gallusNCBI:XP_413884 · ENTREZ:415513
G. gallusNCBI:XP_425878 · ENTREZ:428318
G. gallusNCBI:XP_424486 · ENTREZ:426879
G. gallusNCBI:XP_418172 · ENTREZ:420050
G. gallusNCBI:XP_001233814 · ENTREZ:771503
G. gallusNCBI:XP_424275 · ENTREZ:426648
H. sapiensENSEMBL:ENSG00000143418 · UniProtKB:Q96G23 (TMSG1 · IPI00305304 · LASS2_HUMAN · Q96G23 · LASS2)LAG1 longevity assurance homolog 2⌘
H. sapiensENSEMBL:ENSG00000154227 · UniProtKB:Q8IU89 (LASS3_HUMAN · LASS3 · Q8IU89 · IPI00216667)LAG1 longevity assurance homolog 3⌘
H. sapiensENSEMBL:ENSG00000090661 · UniProtKB:Q9HA82 (LASS4_HUMAN · IPI00002225 · LASS4 · Q9HA82)LAG1 longevity assurance homolog 4⌘
H. sapiensENSEMBL:ENSG00000139624 · UniProtKB:Q8N5B7 (LASS5_HUMAN · IPI00166833 · LASS5 · Q8N5B7)LAG1 longevity assurance homolog 5⌘
H. sapiensENSEMBL:ENSG00000172292 · UniProtKB:Q6ZMG9 (LASS6_HUMAN · IPI00409608 · Q6ZMG9 · LASS6)LAG1 longevity assurance homolog 6⌘
M. musculusUniProtKB:Q924Z4 · MGI:MGI:1924143 (Trh3 · Lass2)LAG1 homolog, ceramide synthase 2⌘
M. musculusUniProtKB:Q9D6J1 · MGI:MGI:1914510 (Lass4 · Trh1)LAG1 homolog, ceramide synthase 4⌘
M. musculusUniProtKB:Q9D6K9 · MGI:MGI:1919199 (Trh4 · Lass5 · CerS5)LAG1 homolog, ceramide synthase 5⌘
M. musculusUniProtKB:Q8C172 · MGI:MGI:2442564 (Lass6 · T1L)similar to TRH1 · LAG1 homolog, ceramide synthase 6⌘
M. musculusUniProtKB:Q195J4 · MGI:MGI:2681008 (Lass3 · LOC233330 · T3L)related to TRH3 · LAG1 homolog, ceramide synthase 3⌘
R. norvegicusNCBI:XP_221796 · RGD:1309303 (Lass4)LAG1 homolog, ceramide synthase 4⌘
R. norvegicusNCBI:XP_001059767 · RGD:1564356 (Lass3)LAG1 homolog, ceramide synthase 3⌘
R. norvegicusNCBI:XP_001063108 · RGD:1311597 (Lass5)LAG1 homolog, ceramide synthase 5⌘
R. norvegicusNCBI:XP_345364 · RGD:1561599 (Lass6)LAG1 homolog, ceramide synthase 6⌘
R. norvegicusUniProtKB:Q3T1K1 (IPI00208183 · Q3T1K1 · Lass2) · RGD:1310059 (Lass2)LAG1 homolog, ceramide synthase 2⌘⌘
S. cerevisiaeUniProtKB:P28496 · SGD:S000001491 (YKL008C · DGT1 · LAC1)Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p⌘
S. cerevisiaeUniProtKB:P38703 · SGD:S000000995 (YHL003C · LAG1)Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p⌘
S. pombeUniProtKB:O59735 · GeneDB_Spombe:SPBC3E7.15c (SPBC4F6.02c · SPBC3E7.15c · mug83 · lac1)sphingosine N-acyltransferase Lac1⌘
S. pombeUniProtKB:P78970 · GeneDB_Spombe:SPAC1A6.09c (SPAC1A6.09c · lag1)sphingosine N-acyltransferase Lag1⌘
ProteinPublicationCurator Notes
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The C. elegans protein C09G4.1 complements a homologous mutation in S. cerevisiae. This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The C. elegans protein C09G4.1 complements a homologous mutation in S. cerevisiae. This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein Q15629 does not complement a homologous mutation in S. cerevisiae. This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein Q15629 does not complement a homologous mutation in S. cerevisiae. This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 complements a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 complements a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 does not complement a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 does not complement a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9HA82 complements a homologous mutation in S. cerevisiae. This paper shows that human LASS4 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9HA82 complements a homologous mutation in S. cerevisiae. This paper shows that human LASS4 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9UBY8 does not complement a homologous mutation in S. cerevisiae. This paper shows that human CLN8 does not complement a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9UBY8 does not complement a homologous mutation in S. cerevisiae. This paper shows that human CLN8 does not complement a yeast lag1 lac1 mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (3)
UniProtKB:P38703 · SGD:S000000995PMID:19148536 Teufel A, et al. (2009) The longevity assurance homologue of yeast lag1 (Lass) gene family (Review). Int J Mol Med 23(2):135-40
UniProtKB:P38703 · SGD:S000000995PMID:19148536 Teufel A, et al. (2009) The longevity assurance homologue of yeast lag1 (Lass) gene family (Review). Int J Mol Med 23(2):135-40
PMID:15317812 Koybasi S, et al. (2004) Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 279(43):44311-9
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu