P-POD: Princeton Protein Orthology Database: GO3/Para3923

This family has 7 members: 1 Arabidopsis thaliana, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Homo sapiens, 1 Mus musculus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

7 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_194284.2 · TAIR:locus:2131829 (M7J2_90 · ATMSH3 · M7J2.90 · AT4G25540 · MSH3)Arabidopsis homolog of DNA mismatch repair protein MSH3⌘
D. rerioUniProtKB:A2CE81 · ENSEMBL:ENSDARG00000063276
D. discoideumUniProtKB:Q1ZXH0 · dictyBase:DDB_G0281683 (msh3)mutS homolog, DNA mismatch repair protein⌘
H. sapiensENSEMBL:ENSG00000113318 · UniProtKB:P20585 (MSH3_HUMAN · IPI00329605 · DUG · DUC1 · MSH3 · P20585)DNA mismatch repair protein Msh3⌘
M. musculusUniProtKB:P13705 · MGI:MGI:109519 (Rep-3 · D13Em1 · Msh3 · Rep3)mutS homolog 3 (E. coli)⌘
S. cerevisiaeUniProtKB:P25336 · SGD:S000000688 (YCR092C · MSH3)Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability⌘
S. pombeUniProtKB:P26359 · GeneDB_Spombe:SPAC8F11.03 (swi4 · msh3 · SPAC8F11.03)MutS protein homolog 3⌘

No functional conservation results.

Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P25336 · SGD:S000000688#608089 ENDOMETRIAL CANCER
SGD Disease Papers (4)
UniProtKB:P25336 · SGD:S000000688PMID:9740671 Her C and Doggett NA (1998) Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene. Genomics 52(1):50-61
PMID:9024626 Fishel R and Wilson T (1997) MutS homologs in mammalian cells. Curr Opin Genet Dev 7(1):105-13
PMID:8782829 Risinger JI, et al. (1996) Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet 14(1):102-5
PMID:8600025 Marsischky GT, et al. (1996) Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair. Genes Dev 10(4):407-20
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