P-POD: Princeton Protein Orthology Database: GO3/Para313

This family has 36 members: 7 Arabidopsis thaliana, 3 Caenorhabditis elegans, 6 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 3 Gallus gallus, 3 Homo sapiens, 2 Mus musculus, 4 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Para313
36 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_565681.1 · TAIR:locus:2043132 (AT2G29390 · F16P2_23 · ATSMO2 · SMO2-2 · F16P2.23)STEROL 4-ALPHA-METHYL-OXIDASE 2-2 · STEROL 4-ALPHA-METHYL-OXIDASE 2⌘
A. thalianaNCBI:NP_192948.1 · TAIR:locus:2118121 (F16J13_180 · F16J13.180 · ATSMO1 · AT4G12110 · SMO1-1 · ATSMO1-1)STEROL-4ALPHA-METHYL OXIDASE 1-1 · STEROL 4-ALPHA-METHYL-OXIDASE 1⌘
A. thalianaNCBI:NP_567670.1 · TAIR:locus:505006515 (SMO1 · ATSMO1-2 · SMO1-2 · ATSMO1 · AT4G22756)STEROL C4-METHYL OXIDASE 1 · STEROL 4-ALPHA-METHYL-OXIDASE 1 · STEROL C4-METHYL OXIDASE 1-2⌘
A. thalianaNCBI:NP_177122.2 · TAIR:locus:2026756 (SBH1 · AT1G69640 · F24J1.22)SPHINGOID BASE HYDROXYLASE 1⌘
A. thalianaNCBI:NP_563789.1 · TAIR:locus:2024982 (F22G5.23 · AT1G07420 · F22G5_23 · ATSMO2 · SMO2-1)STEROL 4-ALPHA-METHYL-OXIDASE 2-1 · STEROL 4-ALPHA-METHYL-OXIDASE 2⌘
A. thalianaNCBI:NP_563944.1 · TAIR:locus:2012512 (F14L17.5 · SBH2 · AT1G14290 · F14L17_5)SPHINGOID BASE HYDROXYLASE 2⌘
A. thalianaNCBI:NP_567669.1 · TAIR:locus:505006514 (ATSMO1-3 · SMO1 · ATSMO1 · SMO1-3 · AT4G22753)STEROL C4-METHYL OXIDASE 1 · STEROL 4-ALPHA METHYL OXIDASE 1-3 · STEROL 4-ALPHA-METHYL-OXIDASE 1⌘
C. elegansWB:WBGene00018036 (F35C8.5) · UniProtKB:Q20027⌘
C. elegansWB:WBGene00009902 (F49E12.9) · UniProtKB:Q20611⌘
C. elegansWB:WBGene00009903 (F49E12.10) · UniProtKB:Q20612⌘
D. rerioENSEMBL:ENSDARP00000056559
D. rerioUniProtKB:Q5PRC0 · ZFIN:ZDB-GENE-041212-81 (ch25h)cholesterol 25-hydroxylase⌘
D. rerioUniProtKB:Q567X1 · ZFIN:ZDB-GENE-030131-8617 (si:dkey-24l11.8)⌘
D. rerioUniProtKB:Q7ZW77 · ZFIN:ZDB-GENE-040426-2670 (sc4mol)sterol-C4-methyl oxidase-like⌘
D. rerioZFIN:ZDB-GENE-050419-90 (si:dkey-24l11.9) · UniProtKB:Q1LX59⌘
D. rerioZFIN:ZDB-GENE-040426-2907 (zgc:55420) · UniProtKB:Q803P4⌘
D. discoideumUniProtKB:Q55D52 · dictyBase:DDB_G0270946 (DDB_G0270946)Putative sterol 4-alpha-methyl-oxidase.⌘
D. discoideumUniProtKB:Q55D54 · dictyBase:DDB_G0269788 (DDB_G0269788)Similar to sterol-C4-methyl oxidase-like.⌘
D. melanogasterFB:FBgn0030509 (CG11162) · UniProtKB:Q9VYA2⌘
D. melanogasterFB:FBgn0030485 (CG1998) · UniProtKB:Q9VYD2⌘
G. gallusNCBI:XP_421660 · ENTREZ:423788
G. gallusNCBI:XP_414576 · ENTREZ:416256
G. gallusENTREZ:422423 · UniProtKB:Q5ZLL6 (SC4MOL · IPI00578812 · Q5ZLL6 · ERG25_CHICK · RCJMB04_5j19)C-4 methylsterol oxidase⌘
H. sapiensENSEMBL:ENSG00000170271 · UniProtKB:Q96IV6 (IPI00063851 · Q96IV6 · CE004_HUMAN · C5orf4)Uncharacterized protein C5orf4⌘
H. sapiensENSEMBL:ENSG00000138135 · UniProtKB:O95992 (IPI00022560 · CH25H_HUMAN · O95992 · CH25H)Cholesterol 25-hydroxylase⌘
H. sapiensENSEMBL:ENSG00000052802 · UniProtKB:Q15800 (ERG25 · SC4MOL · IPI00019899 · Q15800 · ERG25_HUMAN · DESP4)C-4 methylsterol oxidase⌘
M. musculusUniProtKB:Q9Z0F5 · MGI:MGI:1333869 (Ch25h · m25OH)cholesterol 25-hydroxylase⌘
M. musculusUniProtKB:Q9CRA4 · MGI:MGI:1913484 (C78600 · ERG25 · Sc4mol · DESP4)sterol-C4-methyl oxidase-like⌘
R. norvegicusNCBI:XP_001075174 · RGD:1594987 (LOC686661)similar to CG1998-PA⌘
R. norvegicusUniProtKB:Q4QQV7 · RGD:1310575 (Ch25h)cholesterol 25-hydroxylase⌘
R. norvegicusUniProtKB:O35532 · RGD:620281 (Sc4mol)sterol-C4-methyl oxidase-like⌘
R. norvegicusNCBI:XP_001077260 · RGD:1586284 (LOC691221)similar to CG1998-PA⌘
S. cerevisiaeUniProtKB:P53045 · SGD:S000003292 (YGR060W · ERG25)C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis⌘
S. cerevisiaeUniProtKB:P38992 · SGD:S000002705 (SUR2 · YDR297W · SYR2)Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis⌘
S. pombeUniProtKB:Q9UUH4 · GeneDB_Spombe:SPAC630.08c (erg25 · SPAC630.08c)C-4 methylsterol oxidase⌘
S. pombeUniProtKB:O94298 · GeneDB_Spombe:SPBC887.15c (SPBC887.15c)sphingosine hydroxylase⌘
ProteinPublicationCurator Notes
UniProtKB:P38992 · SGD:S000002705PMID:12956060 Beckmann C, et al. Stereochemistry of a bifunctional dihydroceramide delta 4-desaturase/hydroxylase from Candida albicans; a key enzyme of sphingolipid metabolism. Org Biomol Chem. 2003 Jul 21;1(14):2448-54.The C. albicans protein DES1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper describes the biochemical characterization of C. albicans DES1 expressed in an S. cerevisiae sur2 null mutant.
UniProtKB:P38992 · SGD:S000002705PMID:16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92.The P. pastoris protein Q2QJ12_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris sphingolipid C9-methyltransferase in an S. cerevisiae sur2 null mutant.
UniProtKB:P38992 · SGD:S000002705PMID:16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92.The P. pastoris protein Q66VZ4_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris delta 4-(E)-sphingolipid desaturase in an S. cerevisiae sur2 null mutant.
UniProtKB:P38992 · SGD:S000002705PMID:16339149 Ternes P, et al. Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling. J Biol Chem. 2006 Mar 3;281(9):5582-92.The P. pastoris protein Q66VZ5_PICPA was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of P. pastoris delta 8-(E)-sphingolipid desaturase in an S. cerevisiae sur2 null mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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