This family has 40 members: 2 Caenorhabditis elegans, 5 Danio rerio, 3 Drosophila melanogaster, 6 Gallus gallus, 7 Homo sapiens, 7 Mus musculus, 7 Rattus norvegicus, 1 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| C. elegans | UniProtKB:Q9BKW4 · WB:WBGene00022358 (Y92H12A.2) |  | |
| C. elegans | WB:WBGene00007009 (Y65B4BR.4 · wwp-1) · UniProtKB:Q9N2Z7 (Y65B4BR.4 · wwp-1) | Ww domain protein (E3 ubiquitin ligase) protein 1, isoform a | |
| D. rerio | ENSEMBL:ENSDARP00000078496 | ||
| D. rerio | ENSEMBL:ENSDARP00000055490 | ||
| D. rerio | ENSEMBL:ENSDARG00000061345 · UniProtKB:A2VCZ7 | ||
| D. rerio | UniProtKB:Q3KRP0 · ZFIN:ZDB-GENE-051005-2 (nedd4a) | neural precursor cell expressed, developmentally down-regulated 4a | |
| D. rerio | UniProtKB:Q6PCR3 · ZFIN:ZDB-GENE-040426-2744 (wwp1) | WW domain containing E3 ubiquitin protein ligase 1 | |
| D. melanogaster | FB:FBgn0036736 · UniProtKB:Q9VVI3 | ||
| D. melanogaster | UniProtKB:Q9V853 · FB:FBgn0029006 (dSmurf1 · dSmurf · d-smurf · Smurf · lack · CG4943 · Smurf1 · D-smurf · DSmurf · Dsmurf) | Smurf ubiquitin ligase · lethal with a checkpoint kinase | |
| D. melanogaster | UniProtKB:Q9Y0H4 · FB:FBgn0003557 (CG4244 · anon-WO0073329.1 · Su(dx) · anon-WO0073329.4 · su(dx) · Su(Dx) · anon-WO0073329.2 · Su(deltex)) | Suppressor of deltex · Suppressor of Deltex · suppressor of deltex | |
| G. gallus | NCBI:XP_424462 · ENTREZ:374119 | ||
| G. gallus | NCBI:XP_417330 · ENTREZ:419145 | ||
| G. gallus | NCBI:XP_425380 · ENTREZ:427809 | ||
| G. gallus | NCBI:XP_414794 · ENTREZ:416487 | ||
| G. gallus | UniProtKB:Q5F372 (RCJMB04_30i22 · IPI00580040 · Q5F372) · ENTREZ:420212 | | |
| G. gallus | UniProtKB:Q5F427 (RCJMB04_3l19 · IPI00822818 · Q5F427) · ENTREZ:415868 | | |
| H. sapiens | ENSEMBL:ENSG00000078747 · UniProtKB:Q96J02 (ITCH_HUMAN · IPI00061780 · IPI00176010 · Q96J02 · ITCH) | E3 ubiquitin-protein ligase Itchy homolog | |
| H. sapiens | ENSEMBL:ENSG00000049759 · UniProtKB:Q96PU5 (IPI00640924 · IPI00166830 · NEDD4L · IPI00304945 · Q96PU5 · IPI00644256 · IPI00645053 · KIAA0439 · NED4L_HUMAN · IPI00163321 · NEDL3 · IPI00023287 · IPI00643856) | E3 ubiquitin-protein ligase NEDD4-like | |
| H. sapiens | ENSEMBL:ENSG00000069869 · UniProtKB:P46934 (NEDD4_HUMAN · P46934 · IPI00009322 · KIAA0093 · NEDD4) | E3 ubiquitin-protein ligase NEDD4 | |
| H. sapiens | ENSEMBL:ENSG00000198742 · UniProtKB:Q9HCE7 (SMUF1_HUMAN · IPI00219332 · IPI00217054 · KIAA1625 · SMURF1 · Q9HCE7) | E3 ubiquitin-protein ligase SMURF1 | |
| H. sapiens | ENSEMBL:ENSG00000108854 · UniProtKB:Q9HAU4 (IPI00329664 · SMUF2_HUMAN · Q9HAU4 · SMURF2) | E3 ubiquitin-protein ligase SMURF2 | |
| H. sapiens | ENSEMBL:ENSG00000123124 · UniProtKB:Q9H0M0 (WWP1_HUMAN · IPI00328376 · IPI00328378 · IPI00013009 · Q9H0M0 · IPI00328377 · WWP1) | NEDD4-like E3 ubiquitin-protein ligase WWP1 | |
| H. sapiens | ENSEMBL:ENSG00000198373 · UniProtKB:O00308 (IPI00013010 · WWP2 · O00308 · WWP2_HUMAN) | NEDD4-like E3 ubiquitin-protein ligase WWP2 | |
| M. musculus | UniProtKB:Q8C863 · MGI:MGI:1202301 (Itch) | itchy, E3 ubiquitin protein ligase | |
| M. musculus | UniProtKB:Q8CFI0 · MGI:MGI:1933754 (Nedd4b · Nedd4l · Nedd4-2) | neural precursor cell expressed, developmentally down-regulated gene 4-like | |
| M. musculus | UniProtKB:P46935 · MGI:MGI:97297 (Nedd4a · Nedd4 · Nedd4-1) | neural precursor cell expressed, developmentally down-regulated 4 | |
| M. musculus | UniProtKB:Q9CUN6 · MGI:MGI:1923038 (Smurf1) | SMAD specific E3 ubiquitin protein ligase 1 | |
| M. musculus | UniProtKB:A2A5Z6 · MGI:MGI:1913563 (Smurf2) | SMAD specific E3 ubiquitin protein ligase 2 | |
| M. musculus | UniProtKB:Q8BZZ3 · MGI:MGI:1861728 (Tiul1 · AIP5 · SDRP1 · Wwp1) | WW domain containing E3 ubiquitin protein ligase 1 | |
| M. musculus | UniProtKB:Q9DBH0 · MGI:MGI:1914144 (Wwp2) | WW domain containing E3 ubiquitin protein ligase 2 | |
| R. norvegicus | NCBI:XP_001081579 · RGD:1310067 (Smurf2) | SMAD specific E3 ubiquitin protein ligase 2 | |
| R. norvegicus | NCBI:XP_001071299 · RGD:1309707 | ||
| R. norvegicus | NCBI:XP_214669 · RGD:1310091 (Wwp2) | WW domain containing E3 ubiquitin protein ligase 2 | |
| R. norvegicus | NCBI:XP_001074660 · RGD:1594738 (LOC690516) | similar to Smad ubiquitination regulatory factor 1 isoform 2 | |
| R. norvegicus | UniProtKB:Q62940 · RGD:3157 (Nedd4) | neural precursor cell expressed, developmentally down-regulated gene 4 | |
| R. norvegicus | UniProtKB:Q4V8H7 · RGD:1311734 (Wwp1) | WW domain containing E3 ubiquitin protein ligase 1 | |
| R. norvegicus | UniProtKB:Q5YB86 · RGD:1359556 (Itch) | itchy E3 ubiquitin protein ligase homolog (mouse) | |
| S. cerevisiae | UniProtKB:P39940 · SGD:S000000927 (NPI1 · UBY1 · SMM1 · YER125W · RSP5 · MUT2 · MDP1) | Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation | |
| S. pombe | UniProtKB:Q92462 · GeneDB_Spombe:SPAC11G7.02 (SPAC11G7.02 · pub1) | HECT-type ubiquitin-protein ligase Pub1 | |
| S. pombe | UniProtKB:O14326 · GeneDB_Spombe:SPBC16E9.11c (SPBC16E9.11c · pub3) | HECT-type ubiquitin-protein ligase Pub3 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P39940 · SGD:S000000927 |  12684839 Gajewska B, et al. Functional analysis of the human orthologue of the RSP5-encoded ubiquitin protein ligase, hNedd4, in yeast. Curr Genet. 2003 Apr;43(1):1-10. | The H. sapiens protein P46934 does not complement a homologous mutation in S. cerevisiae. This paper shows that hNedd4 (P46934) improved the growth and partially suppressed the endocytosis defect of yeast rsp5-w1 mutant cells, but it did not restore the viability of the yeast rsp5 null mutant. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (1) | |
|---|---|
| UniProtKB:P39940 · SGD:S000000927 | 12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82 |