P-POD: Princeton Protein Orthology Database: GO3/Para3

This family has 57 members: 11 Arabidopsis thaliana, 4 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 3 Drosophila melanogaster, 7 Gallus gallus, 8 Homo sapiens, 8 Mus musculus, 7 Rattus norvegicus, 3 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

Interactive Java Applets: · Jalview Alignment

GO3/Para3
57 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2030180 (F28P22_11 · AT1G72700 · F28P22.11) · NCBI:NP_177414.1⌘
A. thalianaNCBI:NP_568146.1 · TAIR:locus:3355727 (ALA1 · AT5G04930)aminophospholipid ATPase1⌘
A. thalianaNCBI:NP_189189.1 · TAIR:locus:2102345 (T5M7.10 · AT3G25610)⌘
A. thalianaNCBI:NP_189425.1 · TAIR:locus:2086465 (K16N12.23 · AT3G27870)⌘
A. thalianaNCBI:NP_177038.1 · TAIR:locus:2026900 (F24J5.6 · F24J5_6 · AT1G68710)⌘
A. thalianaNCBI:NP_172780.1 · TAIR:locus:2031860 (F3F19.24 · ACA.l · F3F19_24 · AT1G13210)autoinhibited Ca2+/ATPase II⌘
A. thalianaNCBI:NP_173938.1 · TAIR:locus:2011420 (F28B23_19 · F28B23.19 · AT1G26130)⌘
A. thalianaNCBI:NP_175830.1 · TAIR:locus:2020038 (F20D21_10 · AT1G54280 · F20D21.10)⌘
A. thalianaNCBI:NP_188006.1 · TAIR:locus:2088217 (AT3G13900 · MDC16.2)⌘
A. thalianaNCBI:NP_176191.1 · TAIR:locus:2025961 (AT1G59820 · ALA3 · F23H11.14 · F23H11_14)Aminophospholipid ATPase3⌘
A. thalianaNCBI:NP_173193.2 · TAIR:locus:2007858 (AT1G17500 · F1L3.21 · F1L3_21)⌘
C. elegansWB:WBGene00012360 (W09D10.2 · tat-3) · UniProtKB:O18182⌘
C. elegansWB:WBGene00020784 (T24H7.5 · tat-4) · UniProtKB:Q10463⌘
C. elegansWB:WBGene00019166 (tat-2 · H06H21.10) · UniProtKB:Q9TXV2⌘
C. elegansWB:WBGene00013034 (Y49E10.11 · tat-1) · UniProtKB:Q9U280⌘
D. rerioENSEMBL:ENSDARG00000062040 · UniProtKB:A2BGP2
D. rerioENSEMBL:ENSDARG00000042285 · UniProtKB:Q1LY58
D. discoideumUniProtKB:Q55E61 · dictyBase:DDB_G0269380 (DDB_G0269380)P-type ATPase⌘
D. melanogasterFB:FBgn0033837 · UniProtKB:Q0E990
D. melanogasterFB:FBgn0032120 (CG18419 · CG13112 · CG33298) · UniProtKB:Q7KTG6⌘
D. melanogasterFB:FBgn0037989 (CG14741) · UniProtKB:Q9VGD4⌘
G. gallusNCBI:XP_429208 · ENTREZ:431656
G. gallusNCBI:XP_416881 · ENTREZ:418685
G. gallusNCBI:XP_420729 · ENTREZ:422776
G. gallusNCBI:XP_414491 · ENTREZ:416159
G. gallusNCBI:XP_420722 · ENTREZ:422768
G. gallusNCBI:XP_425888 · ENTREZ:428328
G. gallusNCBI:XP_417130 · ENTREZ:418936
H. sapiensENSEMBL:ENSG00000206190 · UniProtKB:O60312 (ATPVC · AT10A_HUMAN · IPI00783442 · O60312 · KIAA0566 · ATP10A · ATP10C)Probable phospholipid-transporting ATPase VA⌘
H. sapiensENSEMBL:ENSG00000118322 · UniProtKB:O94823 (ATPVB · O94823 · IPI00852619 · ATP10B · IPI00186385 · IPI00293928 · KIAA0715 · AT10B_HUMAN)Probable phospholipid-transporting ATPase VB⌘
H. sapiensENSEMBL:ENSG00000145246 · UniProtKB:Q9P241 (AT10D_HUMAN · IPI00216521 · IPI00001723 · ATP10D · Q9P241 · KIAA1487)Probable phospholipid-transporting ATPase VD⌘
H. sapiensENSEMBL:ENSG00000124406 · UniProtKB:Q9Y2Q0 (ATP8A1 · IPI00221038 · ATPIA · Q9Y2Q0 · AT8A1_HUMAN · IPI00032402)Probable phospholipid-transporting ATPase IA⌘
H. sapiensENSEMBL:ENSG00000132932 · UniProtKB:Q9NTI2 (AT8A2_HUMAN · IPI00465166 · Q9NTI2 · ATP8A2 · ATPIB · IPI00337792)Probable phospholipid-transporting ATPase IB⌘
H. sapiensENSEMBL:ENSG00000143515 · UniProtKB:P98198 (AT8B2_HUMAN · IPI00396074 · KIAA1137 · P98198 · ATPID · ATP8B2 · IPI00258027)Probable phospholipid-transporting ATPase ID⌘
H. sapiensENSEMBL:ENSG00000130270 · UniProtKB:O60423 (AT8B3_HUMAN · IPI00237913 · ATP1K · IPI00216974 · FOS37502_2 · ATP8B3 · O60423)Probable phospholipid-transporting ATPase IK⌘
H. sapiensENSEMBL:ENSG00000104043 · UniProtKB:Q8TF62 (ATP8B4 · Q8TF62 · AT8B4_HUMAN · IPI00152868 · KIAA1939)Probable phospholipid-transporting ATPase IM⌘
M. musculusNCBI:NP_795973 · MGI:MGI:2442688
M. musculusNCBI:NP_001074413 · MGI:MGI:1859664 (Im · Atp8b4)ATPase, class I, type 8B, member 4⌘
M. musculusNCBI:NP_080370 · MGI:MGI:1914581 (SAPLT · Atp8b3)ATPase, class I, type 8B, member 3⌘
M. musculusUniProtKB:O54827 · MGI:MGI:1330809 (Atp10a · Atp10c · pfatp)ATPase, class V, type 10A⌘
M. musculusUniProtKB:Q8K2X1 · MGI:MGI:2450125 (IMAGE:1069176 · D5Buc24e · Atp10d)ATPase, class V, type 10D⌘
M. musculusUniProtKB:P70704 · MGI:MGI:1330848 (Atp3a2 · Atp8a1)ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1⌘
M. musculusUniProtKB:P98200 · MGI:MGI:1354710 (Atp8a2 · Ib)ATPase, aminophospholipid transporter-like, class I, type 8A, member 2⌘
M. musculusUniProtKB:P98199 · MGI:MGI:1859660 (Atp8b2 · Id)ATPase, class I, type 8B, member 2⌘
R. norvegicusNCBI:XP_224270 · RGD:1561428
R. norvegicusNCBI:XP_341210 · RGD:1588541 (Atp10d)ATPase, class V, type 10D⌘
R. norvegicusNCBI:XP_001070245 · RGD:1309619 (Atp8a1)ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1⌘
R. norvegicusNCBI:XP_001062555 · RGD:1597731 (LOC685152)similar to Probable phospholipid-transporting ATPase ID (ATPase class I type 8B member 2)⌘
R. norvegicusUniProtKB:Q32Q02 · RGD:1306150 (Atp10a)ATPase, class V, type 10A⌘
R. norvegicusNCBI:XP_234937 · RGD:1307622 (Atp8b3)ATPase, Class I, type 8B, member 3⌘
R. norvegicusNCBI:XP_220314 · RGD:1565126 (Atp10b)ATPase, class V, type 10B⌘
S. cerevisiaeUniProtKB:P39524 · SGD:S000000024 (FUN38 · DRS2 · SWA3 · YAL026C)Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles⌘
S. cerevisiaeUniProtKB:Q12675 · SGD:S000002500 (YDR093W · DNF2)Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane⌘
S. cerevisiaeUniProtKB:P32660 · SGD:S000000968 (DNF1 · YER166W)Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane⌘
S. pombeUniProtKB:Q09891 · GeneDB_Spombe:SPAC24B11.12c (SPAC24B11.12c)P-type ATPase⌘
S. pombeUniProtKB:O36028 · GeneDB_Spombe:SPAC4F10.16c (SPAC4F10.16c)P-type ATPase⌘
S. pombeUniProtKB:O94296 · GeneDB_Spombe:SPBC887.12 (SPBC887.12)P-type ATPase⌘
ProteinPublicationCurator Notes
UniProtKB:P39524 · SGD:S000000024PMID:11148289 Gomès E, et al. Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases. Plant Cell. 2000 Dec;12(12):2441-2454.The A. thaliana protein AT5G67260.1 complements a homologous mutation in S. cerevisiae. A. thaliana CYCD3 (AT5G67260.1) is able to complement a yeast cln1 cln2 cln3 triple mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P39524 · SGD:S000000024#105830 ANGELMAN SYNDROME; AS;;HAPPY PUPPET SYNDROME, FORMERLYANGELMAN SYNDROME CHROMOSOME REGION, INCLUDED; ANCR, INCLUDED
SGD Disease Papers (1)
UniProtKB:P39524 · SGD:S000000024PMID:9500542 Bull LN, et al. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18(3):219-24
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