P-POD: Princeton Protein Orthology Database: GO3/Para195

This family has 67 members: 2 Arabidopsis thaliana, 5 Caenorhabditis elegans, 16 Danio rerio, 3 Dictyostelium discoideum, 3 Drosophila melanogaster, 6 Gallus gallus, 9 Homo sapiens, 8 Mus musculus, 8 Rattus norvegicus, 5 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Para195
67 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_187484.1 · TAIR:locus:2077843 (S6K2 · ATS6K2 · F17O14.19 · ATPK19 · ATPK2 · AT3G08720)ARABIDOPSIS THALIANA PROTEIN KINASE 2 · ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2 · Arabidopsis thaliana protein kinase 19⌘
A. thalianaNCBI:NP_187485.1 · TAIR:locus:2077873 (ATPK6 · ATS6K1 · S6K1 · PK1 · ATPK1 · F17O14.20 · PK6 · AT3G08730)ROTEIN-SERINE KINASE 6 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1 · PROTEIN-SERINE KINASE · P70 RIBOSOMAL S6 KINASE · PROTEIN-SERINE KINASE 1 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6⌘
C. elegansWB:WBGene00000102 (C12D8.10 · akt-1) · UniProtKB:Q17941 (C12D8.10 · AKT1_CAEEL · akt-1)Serine/threonine-protein kinase akt-1⌘⌘
C. elegansWB:WBGene00000103 (F28H6.1 · akt-2) · UniProtKB:Q9XTG7 (F28H6.1 · akt-2 · AKT2_CAEEL)Serine/threonine-protein kinase akt-2⌘⌘
C. elegansWB:WBGene00002189 (kin-1 · ZK909.2) · UniProtKB:P21137⌘
C. elegansWB:WBGene00004789 (W10G6.2 · sgk-1) · UniProtKB:Q2PJ68 (W10G6.2 · W10G6.2B · sgk-1)Protein W10G6.2b, partially confirmed by transcript evidence⌘⌘
C. elegansWB:WBGene00012929 (rsks-1 · Y47D3A.16) · UniProtKB:Q9NAH6⌘
D. rerioENSEMBL:ENSDARP00000012715
D. rerioENSEMBL:ENSDARP00000086932
D. rerioENSEMBL:ENSDARP00000087028
D. rerioENSEMBL:ENSDARP00000050022
D. rerioENSEMBL:ENSDARP00000086600
D. rerioUniProtKB:A3KMS9 · ZFIN:ZDB-GENE-070424-14 (zgc:158799)⌘
D. rerioUniProtKB:A4IG56 · ZFIN:ZDB-GENE-070424-62 (sgk3)serum/glucocorticoid regulated kinase family, member 3⌘
D. rerioZFIN:ZDB-GENE-060929-44 (zgc:154065) · UniProtKB:Q08BW4⌘
D. rerioUniProtKB:Q3ZB92 · ZFIN:ZDB-GENE-050904-4 (prkacb)protein kinase, cAMP-dependent, catalytic, beta⌘
D. rerioZFIN:ZDB-GENE-040801-208 (zgc:91856) · UniProtKB:Q6DBV8⌘
D. rerioZFIN:ZDB-GENE-040426-1351 (zgc:64054) · UniProtKB:Q7T374⌘
D. rerioUniProtKB:Q7ZTW4 · ZFIN:ZDB-GENE-030131-2860 (sgk1)serum/glucocorticoid regulated kinase 1⌘
D. rerioUniProtKB:Q802Y3 · ZFIN:ZDB-GENE-040121-5 (akt2l)v-akt murine thymoma viral oncogene homolog 2, like⌘
D. rerioUniProtKB:Q802Y7 · ZFIN:ZDB-GENE-040426-2038 (rps6kb1)ribosomal protein S6 kinase b, polypeptide 1⌘
D. rerioUniProtKB:Q8UUX0 · ZFIN:ZDB-GENE-031007-5 (akt2)v-akt murine thymoma viral oncogene homolog 2⌘
D. rerioZFIN:ZDB-GENE-030131-7626 (si:ch211-195b13.1) · UniProtKB:Q08BB4⌘
D. discoideumUniProtKB:P34099 · dictyBase:DDB_G0283907 (DdPK2 · pkacat · cAK · PK2 · PKA · PKA-C · DdPK3 · PK3 · pkaC)cAMP-dependent protein kinase, protein serine/threonine kinase, protein kinase, AGC group, PKA family protein kinase, protein kinase A catalytic subunit⌘
D. discoideumUniProtKB:P54644 · dictyBase:DDB_G0268620 (pkfC · Akt · PKB · pkbA · AktPKB · DK1)protein serine/threonine kinase, protein kinase, AGC group, AKT family protein kinase, AKT/PKB protein kinase⌘
D. discoideumUniProtKB:P28178 · dictyBase:DDB_G0290157 (DK2 · PKBR1 · pkgB · pkfA · PK2)protein kinase 2, protein serine/threonine kinase, protein kinase, AGC group, SGK family protein kinase⌘
D. melanogasterUniProtKB:Q8INB9 · FB:FBgn0010379 (RAC · pAkt · Dakt · Dakt1 · dAkt/PKB · RacPK · l(3)04226 · dAKT/dPKB · DAkt · l(3)89Bq · akt · Akt · akt1 · dAkt1 · PKB/AKT · PKB · dAkt · DPKB · PKB/Akt · Akt1 · DAKT1 · dAKT · Akt/PKB · dAKT1 · CG4006 · DRAC-PK · DAkt1 · PKB/dAKT · DAKT1/PKB · dakt · dakt1 · dPKB · D-Akt · AKT/PKB · AKT)dAkt kinase · DRAC-PK66; DRAC-PK85 · related to the A and C kinases · Related to PKA to PKC protein kinases⌘
D. melanogasterUniProtKB:P12370 · FB:FBgn0000273 (pka-C1 · Cos1 · PKA · DCO · CdkA · l(2)cos[[1]] · 6353 · DC0 · pkA · pKA · Pka-C · Costal · pka-c1 · l(2)01272 · Dco · l(2)s4402 · CG4379 · Cos-1 · dPKA · PKAc · dcO · PKAcA · C · PkaC1 · pka · Dcpk · Costal-1 · PKA-C1 · Dc0 · cos1 · dco · Pka-C1 · costal-1 · Pka · Cos)Protein Kinase A · catalytic subunit of cAMP-dependent protein kinase · PKA catalytic subunit · PKA Cl · protein kinase A · catalytic subunit of PKA · pka C1 · PKA CI · cAMP-dependent protein kinase 1 · cAMP-dependent protein kinase⌘
D. melanogasterUniProtKB:P91656 · FB:FBgn0015806 (p70[S6K] · dp70[S6k] · p70[S6k] · dps6k · dp70s6k · dS6k · s6k11 · s6k · p70S6K · Dp70S6k · l(3)07084 · 7084 · CG10539 · S6k · DS6K · Dp70[s6k] · p70[S6kinase] · Dp70s6k · S6kinase · S6-kinase · ds6k · dS6K · p70/S6K · fs(3)07084 · S6K · p70s6K)p70 S6K · p70[S6 kinase] · RPS6-p70-protein kinase · dS6 kinase · p70 s6 kinase · S6 kinase⌘
G. gallusNCBI:XP_419544 · ENTREZ:421497
G. gallusNCBI:XP_422379 · ENTREZ:424542
G. gallusUniProtKB:O57513 (IPI00582661 · O57513 · akt1) · ENTREZ:395928⌘
G. gallusUniProtKB:Q5ZJQ4 (IPI00572465 · Q5ZJQ4 · RCJMB04_16g8) · ENTREZ:420167⌘
G. gallusUniProtKB:Q5ZLW5 (IPI00579385 · RCJMB04_4j14 · Q5ZLW5) · ENTREZ:417637⌘
G. gallusUniProtKB:Q6U1I9 (IPI00574209 · Q6U1I9) · ENTREZ:395133⌘
H. sapiensENSEMBL:ENSG00000142208 · UniProtKB:P31749 (AKT1 · RAC · IPI00012866 · P31749 · PKB · AKT1_HUMAN)RAC-alpha serine/threonine-protein kinase⌘
H. sapiensENSEMBL:ENSG00000105221 · UniProtKB:P31751 (AKT2_HUMAN · P31751 · IPI00012870 · AKT2)RAC-beta serine/threonine-protein kinase⌘
H. sapiensENSEMBL:ENSG00000117020 · UniProtKB:Q9Y243 (IPI00219411 · AKT3 · PKBG · AKT3_HUMAN · IPI00031747 · Q9Y243)RAC-gamma serine/threonine-protein kinase⌘
H. sapiensENSEMBL:ENSG00000072062 · UniProtKB:P17612 (KAPCA_HUMAN · PRKACA · PKACA · IPI00396630 · P17612 · IPI00217960)cAMP-dependent protein kinase catalytic subunit alpha⌘
H. sapiensENSEMBL:ENSG00000142875 · UniProtKB:P22694 (IPI00739595 · IPI00738231 · P22694 · IPI00739094 · KAPCB_HUMAN · IPI00395654 · IPI00376119 · IPI00737651 · IPI00737155 · PRKACB)cAMP-dependent protein kinase catalytic subunit beta⌘
H. sapiensENSEMBL:ENSG00000165059 · UniProtKB:P22612 (PRKACG · KAPCG_HUMAN · P22612 · IPI00219592)cAMP-dependent protein kinase catalytic subunit gamma⌘
H. sapiensENSEMBL:ENSG00000108443 · UniProtKB:P23443 (IPI00216132 · STK14A · RPS6KB1 · IPI00759649 · KS6B1_HUMAN · P23443)Ribosomal protein S6 kinase beta-1⌘
H. sapiensENSEMBL:ENSG00000118515 · UniProtKB:O00141 (SGK · IPI00297590 · O00141 · SGK1 · SGK1_HUMAN)Serine/threonine-protein kinase Sgk1⌘
H. sapiensENSEMBL:ENSG00000104205 · UniProtKB:Q96BR1 (IPI00655852 · SGK2 · SGK3_HUMAN · Q96BR1 · SGKL · SGK3)Serine/threonine-protein kinase Sgk3⌘
M. musculusUniProtKB:P31750 · MGI:MGI:87986 (Akt1 · Akt · PKBalpha · PKB · PKB/Akt)thymoma viral proto-oncogene 1⌘
M. musculusUniProtKB:Q60823 · MGI:MGI:104874 (PKBbeta · PKB · Akt2)thymoma viral proto-oncogene 2⌘
M. musculusUniProtKB:Q9WUA6 · MGI:MGI:1345147 (Akt3)PKB gamma · thymoma viral proto-oncogene 3⌘
M. musculusUniProtKB:P05132 · MGI:MGI:97592 (Pkaca · Prkaca · PKA · Cs)protein kinase, cAMP dependent, catalytic, alpha · C alpha⌘
M. musculusUniProtKB:P68181 · MGI:MGI:97594 (Prkacb · Pkacb)protein kinase, cAMP dependent, catalytic, beta · cAMP-dependent protein kinase C beta⌘
M. musculusUniProtKB:Q8BSK8 · MGI:MGI:1270849 (Rps6kb1 · p70s6k · S6K1 · p70/85s6k)ribosomal protein S6 kinase, polypeptide 1⌘
M. musculusUniProtKB:Q9WVC6 · MGI:MGI:1340062 (Sgk · Sgk1)serum/glucocorticoid regulated kinase 1⌘
M. musculusUniProtKB:Q9ERE3 · MGI:MGI:2182368 (Sgk3 · Cisk · fy)cytokine-independent survival kinase · serum/glucocorticoid regulated kinase 3⌘
R. norvegicusUniProtKB:P47196 · RGD:2081 (Akt1)v-akt murine thymoma viral oncogene homolog 1⌘
R. norvegicusUniProtKB:P47197 · RGD:2082 (Akt2)v-akt murine thymoma viral oncogene homolog 2⌘
R. norvegicusUniProtKB:Q63484 · RGD:62390 (Akt3)v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)⌘
R. norvegicusRGD:3389 (Prkaca) · UniProtKB:P27791 (Prkaca · P27791 · IPI00555215 · KAPCA_RAT · IPI00200013)protein kinase, cAMP-dependent, catalytic, alpha · cAMP-dependent protein kinase catalytic subunit alpha⌘⌘
R. norvegicusUniProtKB:P68182 · RGD:1310574 (Prkacb)protein kinase, cAMP dependent, catalytic, beta⌘
R. norvegicusRGD:620683 (Rps6kb1) · UniProtKB:P67999 (Rps6kb1 · IPI00760127 · P67999 · KS6B1_RAT · IPI00471630)ribosomal protein S6 kinase, 70kDa, polypeptide 1 · Ribosomal protein S6 kinase beta-1⌘⌘
R. norvegicusUniProtKB:Q06226 · RGD:3668 (Sgk1)serum/glucocorticoid regulated kinase 1⌘
R. norvegicusUniProtKB:Q8R4V0 · RGD:620242 (Sgk3)serum/glucocorticoid regulated kinase 3⌘
S. cerevisiaeUniProtKB:P06244 · SGD:S000003700 (SRA3 · TPK1 · YJL164C · PKA1)cAMP-dependent protein kinase catalytic subunit⌘
S. cerevisiaeUniProtKB:P06245 · SGD:S000006124 (PKA2 · TPK2 · PKA3 · YPL203W · YKR1)cAMP-dependent protein kinase catalytic subunit⌘
S. cerevisiaeUniProtKB:P05986 · SGD:S000001649 (YKL166C · TPK3)cAMP-dependent protein kinase catalytic subunit⌘
S. cerevisiaeUniProtKB:P12688 · SGD:S000001609 (SLI2 · YPK1 · YKL126W)Serine/threonine protein kinase required for receptor-mediated endocytosis⌘
S. cerevisiaeUniProtKB:P18961 · SGD:S000004710 (YPK2 · YMR104C · YKR2)Protein kinase with similarity to serine/threonine protein kinase Ypk1p⌘
S. pombeUniProtKB:Q9P7J8 · GeneDB_Spombe:SPCC24B10.07 (gad8 · SPCC24B10.07)serine/threonine protein kinase Gad8⌘
S. pombeUniProtKB:P40376 · GeneDB_Spombe:SPBC106.10 (git6 · pka1 · tpk · SPBC106.10)cAMP-dependent protein kinase catalytic subunit Pka1⌘
ProteinPublicationCurator Notes
UniProtKB:P12688 · SGD:S000001609PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P18961 · SGD:S000004710PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P12688 · SGD:S000001609PMID:20516150 Jacquier N, et al. Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids. J Cell Sci. 2010 Jul 1;123(Pt 13):2218-27.The H. sapiens protein SGK1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12688 · SGD:S000001609PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P18961 · SGD:S000004710PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000142208 · UniProtKB:P31749#114480 BREAST CANCER;;BREAST CANCER, FAMILIALBREAST CANCER, FAMILIAL MALE, INCLUDED
UniProtKB:P12688 · SGD:S000001609#604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1BREAST CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED;;OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1, INCLUDED
#114500 COLORECTAL CANCER; CRC;;COLON CANCER
SGD Disease Papers (2)
UniProtKB:P18961 · SGD:S000004710PMID:18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
UniProtKB:P18961 · SGD:S000004710PMID:18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
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