P-POD: Princeton Protein Orthology Database: GO3/Para1753

This family has 89 members: 1 Arabidopsis thaliana, 27 Caenorhabditis elegans, 11 Danio rerio, 1 Dictyostelium discoideum, 4 Drosophila melanogaster, 10 Gallus gallus, 10 Homo sapiens, 9 Mus musculus, 12 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Para1753
89 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_177331.1 · TAIR:locus:2012991 (PTP1 · F14O23_24 · F14O23.24 · ATPTP1 · AT1G71860)PROTEIN TYROSINE PHOSPHATASE 1⌘
C. elegansWB:WBGene00015026 (B0207.1) · UniProtKB:O01435⌘
C. elegansWB:WBGene00018530 (F47B3.6) · UniProtKB:O01555⌘
C. elegansWB:WBGene00018531 (F47B3.7) · UniProtKB:O01556⌘
C. elegansWB:WBGene00018525 (F47B3.1) · UniProtKB:O01557⌘
C. elegansWB:WBGene00017647 (F20H11.4) · UniProtKB:O01736⌘
C. elegansWB:WBGene00009129 (F25H5.7) · UniProtKB:O17840⌘
C. elegansWB:WBGene00019773 (M04G7.2) · UniProtKB:O44180⌘
C. elegansWB:WBGene00015331 (C02B10.6) · UniProtKB:O44448⌘
C. elegansWB:WBGene00022753 (ZK484.7) · UniProtKB:O44901⌘
C. elegansWB:WBGene00015929 (C17H12.3) · UniProtKB:O45085⌘
C. elegansWB:WBGene00018895 (F55F8.7) · UniProtKB:P91345⌘
C. elegansWB:WBGene00020841 (T27A3.5) · UniProtKB:P91498⌘
C. elegansWB:WBGene00022709 (ZK354.8) · UniProtKB:P91568⌘
C. elegansWB:WBGene00016382 (C33H5.16) · UniProtKB:Q18415⌘
C. elegansWB:WBGene00009492 (F36H1.3) · UniProtKB:Q20108⌘
C. elegansWB:WBGene00004214 (ptp-2 · F59G1.5) · UniProtKB:Q21055⌘
C. elegansWB:WBGene00010636 (K07F5.8) · UniProtKB:Q21297⌘
C. elegansWB:WBGene00011918 (T22C1.8) · UniProtKB:Q22668⌘
C. elegansWB:WBGene00012138 (T28F4.3) · UniProtKB:Q22852⌘
C. elegansWB:WBGene00044348 (Y71G12B.31) · UniProtKB:Q4W5R1⌘
C. elegansWB:WBGene00011178 (R09E10.9) · UniProtKB:Q6BEU1⌘
C. elegansWB:WBGene00021702 (Y48G9A.9) · UniProtKB:Q7YZG5⌘
C. elegansWB:WBGene00016942 (C55B7.3) · UniProtKB:Q966M2⌘
C. elegansWB:WBGene00022110 (Y71F9AL.4) · UniProtKB:Q9N4H5⌘
C. elegansWB:WBGene00022777 (ZK616.7) · UniProtKB:Q9N4M9⌘
C. elegansWB:WBGene00021435 (Y39A3A.4) · UniProtKB:Q9N520⌘
C. elegansWB:WBGene00018124 (F36H12.10) · UniProtKB:Q9TZQ1⌘
D. rerioENSEMBL:ENSDARP00000088902
D. rerioENSEMBL:ENSDARP00000023571
D. rerioENSEMBL:ENSDARP00000060241
D. rerioENSEMBL:ENSDARP00000092632
D. rerioUniProtKB:Q7SY11 · ZFIN:ZDB-GENE-040426-1196 (ptpn2)protein tyrosine phosphatase, non-receptor type 2⌘
D. rerioZFIN:ZDB-GENE-040426-1158 (zgc:63553) · UniProtKB:Q7SY37⌘
D. rerioUniProtKB:Q7ZW17 · ZFIN:ZDB-GENE-030131-5911 (ptpn11)protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)⌘
D. rerioUniProtKB:Q7ZWI6 · ZFIN:ZDB-GENE-980605-23 (ptp1b)protein tyrosine phosphatase 1b⌘
D. rerioUniProtKB:Q803R3 · ZFIN:ZDB-GENE-030909-8 (ptpn2l)protein tyrosine phosphatase, non-receptor type 2, like⌘
D. rerioZFIN:ZDB-GENE-050320-12 (zgc:113105) · UniProtKB:B0UYE7⌘
D. rerioUniProtKB:Q803M6 · ZFIN:ZDB-GENE-030131-7513 (ptpn6)protein tyrosine phosphatase, non-receptor type 6⌘
D. discoideumUniProtKB:P34138 · dictyBase:DDB_G0277865 (DdPTPa · ptpB)protein tyrosine phosphatase, phosphotyrosine phosphatase ptp2⌘
D. melanogasterUniProtKB:P29349 · FB:FBgn0000382 (csw · Corkscrew · E(sev)1A · anon-WO03040301.207 · l(1)G0170 · Csw/Shp2 · EG:BACN25G24.2 · l(1)csw · l(1)2Db · l(1)GA114 · CG3954 · l(1)2Dd · Csw · 19-106 · Shp2/csw · anon-WO03040301.219 · CSW · corkscrew · anon-WO03040301.209)Enhancer of sevenless 1A⌘
D. melanogasterUniProtKB:Q9W0G1 · FB:FBgn0003138 (DPTP61F · PTP61F · BEST:LP01280 · ptp61F · CG9178 · anon-WO0118547.297 · dPTP61F · protein-tyrosine-phosphatase · anon-WO0140519.98 · dptp61F · Ptp61F · CG9181)Protein tyrosine phosphatase 61F · protein tyrosine phosphatase · R-PTP 61F⌘
D. melanogasterFB:FBgn0037929 · UniProtKB:Q9VGK4
D. melanogasterUniProtKB:Q9W323 · FB:FBgn0028341 (CG3102 · CG3101 · MEG2 · l(1)G0232 · CG32697)lethal (1) G0232⌘
G. gallusNCBI:XP_001235188 · ENTREZ:771985
G. gallusNCBI:XP_419126 · ENTREZ:396409
G. gallusNCBI:XP_001236792 · ENTREZ:777330
G. gallusNCBI:XP_001235338 · ENTREZ:772163
G. gallusNCBI:XP_413696 · ENTREZ:415308
G. gallusNCBI:XP_001232669 · ENTREZ:770905
G. gallusENTREZ:395815 · UniProtKB:Q90687 (SH-PTP2 · IPI00598624 · Q90687 · PTN11_CHICK · PTPN11)Tyrosine-protein phosphatase non-receptor type 11⌘
G. gallusENTREZ:395688 · UniProtKB:O13016 (PTP1B · PTPN1 · IPI00581788 · O13016 · PTN1_CHICK)Tyrosine-protein phosphatase non-receptor type 1⌘
G. gallusUniProtKB:Q5F3I5 (IPI00601364 · RCJMB04_15p22 · Q5F3I5) · ENTREZ:427947⌘
G. gallusUniProtKB:Q5ZM15 (RCJMB04_3g19 · Q5ZM15 · IPI00577042) · ENTREZ:419429⌘
H. sapiensENSEMBL:ENSG00000179295 · UniProtKB:Q06124 (IPI00658023 · IPI00658002 · Q06124 · PTPN11 · PTP2C · IPI00298347 · SHPTP2 · PTN11_HUMAN)Tyrosine-protein phosphatase non-receptor type 11⌘
H. sapiensENSEMBL:ENSG00000072135 · UniProtKB:Q99952 (BDP1 · Q99952 · PTPN18 · IPI00219132 · PTN18_HUMAN)Tyrosine-protein phosphatase non-receptor type 18⌘
H. sapiensENSEMBL:ENSG00000196396 · UniProtKB:P18031 (PTP1B · PTPN1 · PTN1_HUMAN · IPI00297261 · P18031)Tyrosine-protein phosphatase non-receptor type 1⌘
H. sapiensENSEMBL:ENSG00000183675 · UniProtKB:Q4JDL3 (IPI00740604 · IPI00294644 · PTN20_HUMAN · IPI00181741 · IPI00854794 · IPI00735238 · Q4JDL3 · IPI00854771 · IPI00619950 · IPI00741003 · IPI00735509 · PTPN20B · IPI00854704 · IPI00737076 · IPI00619972 · IPI00854661 · IPI00854625 · IPI00643067 · PTPN20A)Tyrosine-protein phosphatase non-receptor type 20⌘
H. sapiensENSEMBL:ENSG00000204179 · UniProtKB:Q4JDL3 (IPI00740604 · IPI00294644 · PTN20_HUMAN · IPI00181741 · IPI00854794 · IPI00735238 · Q4JDL3 · IPI00854771 · IPI00619950 · IPI00741003 · IPI00735509 · PTPN20B · IPI00854704 · IPI00737076 · IPI00619972 · IPI00854661 · IPI00854625 · IPI00643067 · PTPN20A)Tyrosine-protein phosphatase non-receptor type 20⌘
H. sapiensENSEMBL:ENSG00000175354 · UniProtKB:P17706 (PTN2_HUMAN · IPI00218788 · PTPT · PTPN2 · P17706 · IPI00219695)Tyrosine-protein phosphatase non-receptor type 2⌘
H. sapiensENSEMBL:ENSG00000111679 · UniProtKB:P29350 (P29350 · PTP1C · PTN6_HUMAN · PTPN6 · IPI00183046 · IPI00396552 · HCP · IPI00218604)Tyrosine-protein phosphatase non-receptor type 6⌘
H. sapiensENSEMBL:ENSG00000143851 · UniProtKB:P35236 (PTN7_HUMAN · P35236 · PTPN7 · IPI00081833 · IPI00017338)Tyrosine-protein phosphatase non-receptor type 7⌘
H. sapiensENSEMBL:ENSG00000169410 · UniProtKB:P43378 (PTN9_HUMAN · P43378 · IPI00852804 · PTPN9)Tyrosine-protein phosphatase non-receptor type 9⌘
H. sapiensENSEMBL:ENSG00000153233 · UniProtKB:Q15256 (ECPTP · Q15256 · IPI00217021 · PTPRR_HUMAN · PTPRQ · IPI00107759 · IPI00033560 · PTPRR)Receptor-type tyrosine-protein phosphatase R⌘
M. musculusUniProtKB:P35235 · MGI:MGI:99511 (Shp2 · PTP2C · SH-PTP2 · Syp · Ptpn11 · SHP-2 · PTP1D)SH2 domain-containing protein tyrosine phosphatase-2 · protein tyrosine phosphatase, non-receptor type 11⌘
M. musculusUniProtKB:Q61152 · MGI:MGI:108410 (PTP-HSCF · FLP1 · Ptpk1 · PTP-K1 · HSCF · Ptpn18)protein tyrosine phosphatase, non-receptor type 18⌘
M. musculusUniProtKB:P35821 · MGI:MGI:97805 (PTP1B · PTP-1B · Ptpn1)protein tyrosine phosphatase, non-receptor type 1⌘
M. musculusUniProtKB:O55082 · MGI:MGI:1196295 (Ptpn20 · typ)protein tyrosine phosphatase, non-receptor type 20⌘
M. musculusUniProtKB:Q06180 · MGI:MGI:97806 (Ptpt · Ptpn2 · TC-PTP)protein tyrosine phosphatase, non-receptor type 2⌘
M. musculusUniProtKB:P29351 · MGI:MGI:96055 (SHP-1 · Hcph · Ptpn6 · hcp · Ptp1C)protein tyrosine phosphatase, non-receptor type 6⌘
M. musculusUniProtKB:Q8BUM3 · MGI:MGI:2156893 (LC-PTP · BPTP-4 · Ptpn7)protein tyrosine phosphatase, non-receptor type 7⌘
M. musculusUniProtKB:O35239 · MGI:MGI:1928376 (Meg2 · Ptpn9)protein tyrosine phosphatase, non-receptor type 9⌘
M. musculusUniProtKB:Q62132 · MGI:MGI:109559 (Ptprr · PTPBR7 · PTP-SL)protein tyrosine phosphatase, receptor type, R⌘
R. norvegicusRGD:3447 (Ptpn11) · UniProtKB:P41499 (IPI00324561 · PTN11_RAT · IPI00563975 · Ptpn11 · P41499)protein tyrosine phosphatase, non-receptor type 11 · Tyrosine-protein phosphatase non-receptor type 11⌘⌘
R. norvegicusUniProtKB:P20417 · RGD:61965 (Ptpn1)protein tyrosine phosphatase, non-receptor type 1⌘
R. norvegicusUniProtKB:A1L1L3 · RGD:1309812 (Ptpn20)protein tyrosine phosphatase, non-receptor type 20⌘
R. norvegicusRGD:620710 (Ptpn2) · UniProtKB:P35233 (PTN2_RAT · Ptpn2 · P35233 · IPI00196687)protein tyrosine phosphatase, non-receptor type 2 · Tyrosine-protein phosphatase non-receptor type 2⌘⌘
R. norvegicusUniProtKB:P81718 · RGD:620660 (Ptpn6)protein tyrosine phosphatase, non-receptor type 6⌘
R. norvegicusUniProtKB:P49445 · RGD:708516 (Ptpn7)protein tyrosine phosphatase, non-receptor type 7⌘
R. norvegicusUniProtKB:Q641Z2 · RGD:628726 (Ptpn9)protein tyrosine phosphatase, non-receptor type 9⌘
R. norvegicusRGD:620780 (Ptprr) · UniProtKB:O08617 (IPI00231646 · Ptprr · IPI00231431 · PTPRR_RAT · IPI00231433 · Ptp · O08617 · IPI00231432)protein tyrosine phosphatase, receptor type, R · Receptor-type tyrosine-protein phosphatase R⌘⌘
R. norvegicusUniProtKB:P70602 · RGD:1311586 (Ptpn18)protein tyrosine phosphatase, non-receptor type 18⌘
R. norvegicusUniProtKB:Q562B7 · RGD:1311363 (Ptpn3)protein tyrosine phosphatase, non-receptor type 3⌘
R. norvegicusUniProtKB:Q63745 · RGD:620894 (Ptpn12)protein tyrosine phosphatase, non-receptor type 12⌘
R. norvegicusUniProtKB:Q64642 · RGD:620553 (Ptprh)protein tyrosine phosphatase, receptor type, H⌘
S. cerevisiaeUniProtKB:P25044 · SGD:S000002389 (PTP1 · YDL230W)Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p⌘
S. cerevisiaeUniProtKB:P29461 · SGD:S000005734 (YOR208W · PTP2)Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing⌘
S. pombeUniProtKB:P27574 · GeneDB_Spombe:SPAC26F1.10c (pyp1 · SPAC26F1.10c)tyrosine phosphatase Pyp1⌘
S. pombeUniProtKB:P32587 · GeneDB_Spombe:SPAC11E3.09 (SPAC11E3.09 · pyp3)protein-tyrosine phosphatase Pyp3⌘
ProteinPublicationCurator Notes
UniProtKB:P29461 · SGD:S000005734PMID:1577774 Guan K, et al. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. J Biol Chem. 1992 May 15;267(14):10024-30.The S. cerevisiae protein PTP2 does not complement a homologous mutation in S. pombe.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (4)
ENSEMBL:ENSG00000179295 · UniProtKB:Q06124#151100 LEOPARD SYNDROME 1;;LENTIGINOSIS, CARDIOMYOPATHIC;;MULTIPLE LENTIGINES SYNDROME
ENSEMBL:ENSG00000179295 · UniProtKB:Q06124#607785 JUVENILE MYELOMONOCYTIC LEUKEMIA; JMML;;LEUKEMIA, JUVENILE MYELOMONOCYTIC
#163955 NOONAN-LIKE/MULTIPLE GIANT CELL LESION SYNDROME;;NOONAN SYNDROME WITH PIGMENTED VILLONODULAR SYNOVITIS
#163950 NOONAN SYNDROME 1; NS1;;NOONAN SYNDROME;;MALE TURNER SYNDROME;;FEMALE PSEUDO-TURNER SYNDROME;;TURNER PHENOTYPE WITH NORMAL KARYOTYPEPTERYGIUM COLLI SYNDROME, INCLUDED
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