P-POD: Princeton Protein Orthology Database: GO3/Para1362

This family has 52 members: 2 Arabidopsis thaliana, 4 Caenorhabditis elegans, 6 Danio rerio, 4 Dictyostelium discoideum, 3 Drosophila melanogaster, 1 Escherichia coli, 6 Gallus gallus, 6 Homo sapiens, 6 Mus musculus, 6 Rattus norvegicus, 5 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (3)
• Download Files (5)
• Disease References (6)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

52 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	NCBI:NP_200387.1 · TAIR:locus:2162112 (MDF20_20 · MDF20.20 · AT5G55760 · SRT1)	sirtuin 1
A. thaliana	NCBI:NP_001078550.1 · TAIR:locus:2184717 (T2K12.8 · AT5G09230 · SRT2)	SIRTUIN 2
C. elegans	WB:WBGene00004800 (R11A8.4 · sir-2.1) · UniProtKB:Q21921 (R11A8.4 · SIRT1_CAEEL · sir-2.1)	NAD-dependent deacetylase SIR2 homolog
C. elegans	WB:WBGene00004802 (F46G10.3 · sir-2.3) · UniProtKB:Q20481
C. elegans	WB:WBGene00004801 (sir-2.2 · F46G10.7) · UniProtKB:Q7JMD3
C. elegans	WB:WBGene00004803 (sir-2.4 · C06A5.11) · UniProtKB:Q95Q89
D. rerio	UniProtKB:Q7ZVK3 · ZFIN:ZDB-GENE-030131-1028 (sirt2)	sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
D. rerio	UniProtKB:A1L2B7 · ZFIN:ZDB-GENE-070112-1762 (sirt3)	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
D. rerio	ENSEMBL:ENSDARG00000062893 · UniProtKB:Q1LWD1
D. rerio	ZFIN:ZDB-GENE-041010-65 (zgc:103539) · UniProtKB:Q5XJ86
D. rerio	UniProtKB:Q6DHI5 · ZFIN:ZDB-GENE-040718-349 (sirt5)	sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
D. rerio	UniProtKB:Q6IQK0 · ZFIN:ZDB-GENE-031007-2 (sirt6)	sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
D. discoideum	NCBI:EAL72814.2 · dictyBase:DDB_G0270928 (sir2E)	NAD(+)-dependent deacetylase, silent information regulator protein (Sir2) family protein
D. discoideum	UniProtKB:Q54GV7 · dictyBase:DDB_G0289967 (sir2D)	NAD(+)-dependent deacetylase, silent information regulator protein (Sir2) family protein
D. discoideum	UniProtKB:Q54P49 · dictyBase:DDB_G0284795 (sir2C)	NAD(+)-dependent deacetylase, silent information regulator protein (Sir2) family protein, UBP-type zinc finger-containing protein
D. discoideum	UniProtKB:Q54QE6 · dictyBase:DDB_G0283917 (sir2A)	NAD(+)-dependent deacetylase, silent information regulator protein (Sir2) family protein, UBP-type zinc finger-containing protein
D. melanogaster	FB:FBgn0029783 (Sirt4 · dSIRT4 · D.mel3 · dmSRT407 · CG3187) · UniProtKB:Q8IRR5
D. melanogaster	FB:FBgn0038788 (dSIRT2 · D.mel2 · Sirt2 · CG5085) · UniProtKB:Q9I7I7
D. melanogaster	FB:FBgn0037802 (dmSRT408 · dSIRT6 · CG6284 · Sirt6 · D.mel4) · UniProtKB:Q9VH08
E. coli	UniProtKB:P75960 · ECOLI:G6577-MONOMER (CobB · b1120 · ycfY · ECK1106 · cobB)	protein deacetylase, Sir2 homolog
G. gallus	NCBI:XP_418925 · ENTREZ:420834
G. gallus	NCBI:XP_420920 · ENTREZ:422988
G. gallus	NCBI:XP_415273 · ENTREZ:416981
G. gallus	UniProtKB:Q5ZID4 (IPI00593841 · Q5ZID4 · RCJMB04_27m5) · ENTREZ:548628
G. gallus	UniProtKB:Q5ZMR8 (IPI00735158 · RCJMB04_1f20 · Q5ZMR8) · ENTREZ:428332
G. gallus	UniProtKB:Q68BG0 (sirt1 · Q68BG0 · IPI00583610) · ENTREZ:423646
H. sapiens	ENSEMBL:ENSG00000096717 · UniProtKB:Q96EB6 (SIRT1 · SIRT1_HUMAN · IPI00016802 · SIR2L1 · Q96EB6)	NAD-dependent deacetylase sirtuin-1
H. sapiens	ENSEMBL:ENSG00000068903 · UniProtKB:Q8IXJ6 (SIRT2 · Q8IXJ6 · IPI00179109 · SIRT2_HUMAN · SIR2L2 · SIR2L · IPI00382553 · IPI00382551 · IPI00472047)	NAD-dependent deacetylase sirtuin-2
H. sapiens	ENSEMBL:ENSG00000142082 · UniProtKB:Q9NTG7 (SIRT3_HUMAN · SIR2L3 · SIRT3 · Q9NTG7 · IPI00183171)	NAD-dependent deacetylase sirtuin-3, mitochondrial
H. sapiens	ENSEMBL:ENSG00000089163 · UniProtKB:Q9Y6E7 (SIR2L4 · SIRT4 · Q9Y6E7 · SIRT4_HUMAN · IPI00305620)	NAD-dependent deacetylase sirtuin-4
H. sapiens	ENSEMBL:ENSG00000124523 · UniProtKB:Q9NXA8 (SIRT5_HUMAN · Q9NXA8 · IPI00010331 · SIR2L5 · IPI00016807 · SIRT5)	NAD-dependent deacetylase sirtuin-5
H. sapiens	ENSEMBL:ENSG00000077463 · UniProtKB:Q8N6T7 (IPI00332636 · SIRT6_HUMAN · Q8N6T7 · IPI00396170 · IPI00556638 · SIRT6 · SIR2L6 · IPI00383640)	Mono-ADP-ribosyltransferase sirtuin-6
M. musculus	UniProtKB:Q923E4 · MGI:MGI:2135607 (Sir2alpha · Sirt1 · Sir2)	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
M. musculus	UniProtKB:Q8VDQ8 · MGI:MGI:1927664 (Sirt2 · SIR2L2 · Sir2l)	sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
M. musculus	UniProtKB:Q8R104 · MGI:MGI:1927665 (Sir2l3 · Sirt3)	sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
M. musculus	UniProtKB:Q8R216 · MGI:MGI:1922637 (Sirt4)	sirtuin 4 (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
M. musculus	UniProtKB:Q8K2C6 · MGI:MGI:1915596 (Sirt5)	sirtuin 5 (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
M. musculus	UniProtKB:P59941 · MGI:MGI:1354161 (Sirt6)	sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
R. norvegicus	NCBI:XP_001080262 · RGD:1310413 (Sirt4)	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
R. norvegicus	NCBI:XP_215124 · RGD:1308374 (Sirt3)	sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
R. norvegicus	NCBI:XP_228146 · RGD:1308542 (Sirt1)	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
R. norvegicus	UniProtKB:Q5RJQ4 · RGD:621481 (Sirt2)	sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
R. norvegicus	UniProtKB:Q68FX9 · RGD:1303285 (Sirt5)	sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
R. norvegicus	UniProtKB:Q4FZY2 · RGD:1305216 (Sirt6)	sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
S. cerevisiae	UniProtKB:P53685 · SGD:S000005429 (HST1 · YOL068C)	NAD(+)-dependent histone deacetylase
S. cerevisiae	UniProtKB:P53686 · SGD:S000005936 (YPL015C · HST2)	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases
S. cerevisiae	UniProtKB:P53687 · SGD:S000005551 (HST3 · YOR025W)	Member of the Sir2 family of NAD(+)-dependent protein deacetylases
S. cerevisiae	UniProtKB:P53688 · SGD:S000002599 (YDR191W · HST4)	Member of the Sir2 family of NAD(+)-dependent protein deacetylases
S. cerevisiae	UniProtKB:P06700 · SGD:S000002200 (MAR1 · YDL042C · SIR2)	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan
S. pombe	UniProtKB:Q9USN7 · GeneDB_Spombe:SPCC132.02 (SPCC132.02 · hst2)	Sir2 family histone deacetylase Hst2
S. pombe	UniProtKB:Q9UR39 · GeneDB_Spombe:SPAC1783.04c (SPAC1783.04c · hst4)	Sir2 family histone deacetylase Hst4
S. pombe	UniProtKB:O94640 · GeneDB_Spombe:SPBC16D10.07c (SPBC16D10.07c · sir2)	Sir2 family histone deacetylase Sir2

Protein	Publication	Curator Notes
UniProtKB:P06700 · SGD:S000002200	12618394 Starai VJ, et al. Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics. 2003 Feb;163(2):545-55.	The S. cerevisiae protein SIR2 complements a homologous mutation in S. enterica.
UniProtKB:P06700 · SGD:S000002200	15545655 Freeman-Cook LL, et al. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics. 2005 Mar;169(3):1243-60.	The S. cerevisiae protein SIR2 complements a homologous mutation in S. pombe.
UniProtKB:P06700 · SGD:S000002200	24349441 Gaglio D, et al. Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1. PLoS One. 2013;8(12):e83114.	The H. sapiens protein SIRT1 complements a homologous mutation in S. kluyveri.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

SGD Disease Papers (6)
UniProtKB:P06700 · SGD:S000002200	17110954 Wilson JM, et al. (2006) Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep 7(12):1247-51
UniProtKB:P06700 · SGD:S000002200	17180656 Hida Y, et al. (2007) Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Arch Dermatol Res 299(2):103-6
	17100594 Trapp J and Jung M (2006) The role of NAD+ dependent histone deacetylases (sirtuins) in ageing. Curr Drug Targets 7(11):1553-60
	16362078 Olaharski AJ, et al. (2005) The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet 1(6):e77
	15941577 Guarente L (2005) Calorie restriction and SIR2 genes--towards a mechanism. Mech Ageing Dev 126(9):923-8
	12220851 Smith J (2002) Human Sir2 and the 'silencing' of p53 activity. Trends Cell Biol 12(9):404-6