P-POD: Princeton Protein Orthology Database: GO3/Para1311

This family has 96 members: 17 Arabidopsis thaliana, 8 Caenorhabditis elegans, 12 Danio rerio, 5 Dictyostelium discoideum, 5 Drosophila melanogaster, 10 Gallus gallus, 10 Homo sapiens, 10 Mus musculus, 10 Rattus norvegicus, 4 Saccharomyces cerevisiae, 5 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Para1311
96 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2129780 (FCAALL.219 · AT4G14480 · DL3280C) · NCBI:NP_193184.1⌘
A. thalianaNCBI:NP_188140.1 · TAIR:locus:2087130 (K7L4.2 · AT3G15220)⌘
A. thalianaNCBI:NP_192811.4 · TAIR:locus:2132716 (T12H20_4 · T12H20.4 · AT4G10730)⌘
A. thalianaNCBI:NP_200469.1 · TAIR:locus:2164981 (MIK19.2 · MIK19_2 · ATMKK6 · MKK6 · ANQ1 · AT5G56580)ARABIDOPSIS NQK1 · MAP KINASE KINASE 6 · ARABIDOPSIS THALIANA MAP KINASE KINASE 6⌘
A. thalianaNCBI:NP_172195.1 · TAIR:locus:2007337 (F10K1.14 · AT1G07150 · MAPKKK13 · F10K1_14)⌘
A. thalianaNCBI:NP_175724.2 · TAIR:locus:2824247 (F8L10.20 · AT1G53165)ATMAP4K ALPHA1⌘
A. thalianaNCBI:NP_173782.1 · TAIR:locus:2034888 (F5O8_25 · F5O8.25 · AT1G23700)⌘
A. thalianaNCBI:NP_190600.1 · TAIR:locus:2074835 (AT3G50310 · F11C1.150 · MAPKKK20)⌘
A. thalianaNCBI:NP_196976.2 · TAIR:locus:2185440 (AT5G14720 · T9L3.20 · T9L3_20)⌘
A. thalianaNCBI:NP_201509.1 · TAIR:locus:2155568 (MAPKKK19 · K21H1_4 · K21H1.4 · AT5G67080)⌘
A. thalianaNCBI:NP_177200.1 · TAIR:locus:2016164 (F17O7_3 · AT1G70430 · F17O7.3)⌘
A. thalianaNCBI:NP_178082.3 · TAIR:locus:2019878 (F20B17_7 · AT1G79640 · F20B17.7)⌘
A. thalianaNCBI:NP_198860.1 · TAIR:locus:2170578 (AT5G40440 · MPO12.150 · MPO12_150 · MKK3 · ATMKK3)ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 · MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3⌘
A. thalianaNCBI:NP_001031751.1 · TAIR:locus:2123909 (MKK2 · AT4G29810 · F27B13_50 · MK1 · F27B13.50 · ATMKK2)MAP KINASE KINASE 1 · ARABIDOPSIS THALIANA MAP KINASE KINASE 2 · MAP KINASE KINASE 2⌘
A. thalianaNCBI:NP_194141.2 · TAIR:locus:2135016 (T19F6.90 · AT4G24100 · T19F6_90)⌘
A. thalianaNCBI:NP_194337.1 · TAIR:locus:2120855 (F20B18.180 · ATMEK1 · MEK1 · AT4G26070 · MKK1 · NMAPKK · F20B18_180)MAP KINASE/ ERK KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE⌘
A. thalianaNCBI:NP_180565.1 · TAIR:locus:2045658 (F23F1_4 · F23F1.4 · MAPKKK14 · AT2G30040)⌘
C. elegansWB:WBGene00017472 (cst-1 · F14H12.4) · UniProtKB:Q9NB31⌘
C. elegansWB:WBGene00003186 (Y54E10BL.6 · mek-2) · UniProtKB:Q10664⌘
C. elegansWB:WBGene00003368 (F42G10.2 · mkk-4) · UniProtKB:Q20347 (MKK4_CAEEL · F42G10.2 · mkk-4)MAP kinase kinase mkk-4⌘⌘
C. elegansWB:WBGene00012162 (VZC374L.1) · UniProtKB:O01706⌘
C. elegansWB:WBGene00001526 (T19A5.2 · gck-1) · UniProtKB:Q22553 (T19A5.2 · gck-1)Germinal center kinase family protein 1, isoform a⌘⌘
C. elegansWB:WBGene00016038 (C24A8.4 · cst-2) · UniProtKB:Q304D8⌘
C. elegansWB:WBGene00022613 (ZC449.3) · UniProtKB:Q8MPS3⌘
C. elegansWB:WBGene00013355 (Y59A8B.23 · gck-3) · UniProtKB:Q9GRY2⌘
D. rerioENSEMBL:ENSDARP00000079474
D. rerioENSEMBL:ENSDARP00000090612
D. rerioENSEMBL:ENSDARP00000026314
D. rerioUniProtKB:Q7ZUQ3 · ZFIN:ZDB-GENE-030131-2845 (stk3)serine/threonine kinase 3 (STE20 homolog, yeast)⌘
D. rerioZFIN:ZDB-GENE-070424-52 (zgc:163071) · UniProtKB:A3KP89⌘
D. rerioUniProtKB:Q1LUY7 · ZFIN:ZDB-GENE-040426-2759 (map2k1)mitogen-activated protein kinase kinase 1⌘
D. rerioUniProtKB:Q1LY62 · ZFIN:ZDB-GENE-041027-1 (map2k2)mitogen-activated protein kinase kinase 2⌘
D. rerioZFIN:ZDB-GENE-041010-92 (zgc:92836) · UniProtKB:Q5XIY3⌘
D. rerioUniProtKB:Q7ZVG8 · ZFIN:ZDB-GENE-040426-2537 (stk25)serine/threonine kinase 25 (STE20 homolog, yeast)⌘
D. rerioUniProtKB:Q803V0 · ZFIN:ZDB-GENE-040426-723 (oxsr1b)oxidative-stress responsive 1b⌘
D. rerioUniProtKB:A5PLJ7 · ZFIN:ZDB-GENE-070620-25 (oxsr1a)oxidative-stress responsive 1a⌘
D. rerioUniProtKB:B1NA68 · ZFIN:ZDB-GENE-060512-98 (map2k4)mitogen-activated protein kinase kinase 4⌘
D. discoideumUniProtKB:Q54XL6 · dictyBase:DDB_G0278863 (DFray1 · fray1)putative protein serine/threonine kinase, STE20 family protein kinase, protein kinase, STE group, FRAY subfamily protein kinase⌘
D. discoideumUniProtKB:O61125 · dictyBase:DDB_G0284181 (krsA · Krs1)protein serine/threonine kinase, krs1-like kinase, STE20 family protein kinase, protein kinase, STE group, MST subfamily kinase⌘
D. discoideumUniProtKB:O61122 · dictyBase:DDB_G0286359 (svkA)severin kinase, protein serine/threonine kinase, STE20 family protein kinase, protein kinase, STE group, YST subfamily protein kinase⌘
D. discoideumUniProtKB:Q54PX0 · dictyBase:DDB_G0284251 (DDB_G0284251)putative protein serine/threonine kinase, protein kinase, STE group⌘
D. discoideumUniProtKB:Q55CL6 · dictyBase:DDB_G0269152 (DdMEK1 · mekA · mek1)MAP kinase kinase (MAP2K), STE7 family protein kinase, protein kinase, STE group⌘
D. melanogasterUniProtKB:Q24324 · FB:FBgn0010269 (D-mek · D-sor · MEK1/2 · D-sor-1 · D-Mek · Su(Raf)34B · D-MEK/Dsor · Sor · MEK · dMEK · D-MEK · Dsor1 · D-SOR · MEK/Dsor1 · MAPKK · CG15793 · EK1-1 · DSORT · DSor1 · DSor · Dsor · sor · dsor1 · Dmek · D-Sor · DRODSOR1 · mek · SOR · Mek · dSor · DSOR1 · DMEK-1 · sor/MEK1)Map kinase kinase · Downstream of raf1 · MAPK kinase · downstream suppressor of Raf 1 · Drosophila MEK⌘
D. melanogasterFB:FBgn0034453 (CG11228 · Hpo · Hippo · hippo · MST2 · dMST · hpo) · UniProtKB:Q8T0S6⌘
D. melanogasterUniProtKB:O61444 · FB:FBgn0024326 (MKK4 · DMKK4 · CG9738 · CT27508 · mkk4 · D-MKK4 · SEK1/MKK4 · Mkk4 · dMKK4 · Mpk4 · 142758_at · JNKK2)JNK kinase 2 · MAP kinase kinase 4 · Drosophila MAP kinase kinase 4⌘
D. melanogasterUniProtKB:Q8IGS1 · FB:FBgn0086736 (dGCKIII · CG5169 · GCKIII · GckIII · STLK3)Germinal centre kinase III⌘
D. melanogasterUniProtKB:Q9VE62 · FB:FBgn0023083 (Ste20-like · lag · frayed · fray · l(3)07551 · CG7693 · 4624 · laggard · STE20-like/SPAK · dSTRAD)Ste20-like protein kinase⌘
G. gallusNCBI:XP_418527 · ENTREZ:420421
G. gallusNCBI:XP_422019 · ENTREZ:424173
G. gallusNCBI:XP_415583 · ENTREZ:417312
G. gallusENTREZ:396349 · UniProtKB:Q90891 (IPI00596185 · MKK2 · MAP2K2 · PRKMK2 · Q90891 · MP2K2_CHICK · MEK2)Dual specificity mitogen-activated protein kinase kinase 2⌘
G. gallusENTREZ:419187 · UniProtKB:Q5ZJK4 (RCJMB04_17i1 · STK4_CHICK · STK4 · Q5ZJK4 · IPI00651158)Serine/threonine-protein kinase 4⌘
G. gallusUniProtKB:Q5F3C3 (IPI00595669 · Q5F3C3 · RCJMB04_21o24) · ENTREZ:425375⌘
G. gallusUniProtKB:Q5ZHL2 (RCJMB04_36h7 · Q5ZHL2 · IPI00684847) · ENTREZ:415557⌘
G. gallusUniProtKB:Q5ZIF0 (RCJMB04_27f19 · IPI00580271 · Q5ZIF0) · ENTREZ:415549⌘
G. gallusUniProtKB:Q5ZMA7 (IPI00577023 · Q5ZMA7 · RCJMB04_2k24) · ENTREZ:422231⌘
G. gallusUniProtKB:Q6V9V7 (IPI00587961 · Q6V9V7) · ENTREZ:378801⌘
H. sapiensENSEMBL:ENSG00000169032 · UniProtKB:Q02750 (IPI00219604 · PRKMK1 · MEK1 · Q02750 · MP2K1_HUMAN · MAP2K1)Dual specificity mitogen-activated protein kinase kinase 1⌘
H. sapiensENSEMBL:ENSG00000126934 · UniProtKB:P36507 (MP2K2_HUMAN · IPI00003783 · MKK2 · P36507 · MAP2K2 · PRKMK2 · MEK2)Dual specificity mitogen-activated protein kinase kinase 2⌘
H. sapiensENSEMBL:ENSG00000065559 · UniProtKB:P45985 (MP2K4_HUMAN · MKK4 · MAP2K4 · IPI00024674 · JNKK1 · P45985 · SERK1 · PRKMK4)Dual specificity mitogen-activated protein kinase kinase 4⌘
H. sapiensENSEMBL:ENSG00000137764 · UniProtKB:Q13163 (PRKMK5 · Q13163 · MEK5 · IPI00158248 · MAP2K5 · IPI00219607 · IPI00185860 · MKK5 · MP2K5_HUMAN)Dual specificity mitogen-activated protein kinase kinase 5⌘
H. sapiensENSEMBL:ENSG00000134602 · UniProtKB:Q9P289 (Q9P289 · MST4_HUMAN · MASK · MST4 · IPI00292827)Serine/threonine-protein kinase MST4⌘
H. sapiensENSEMBL:ENSG00000172939 · UniProtKB:O95747 (OXSR1 · OSR1 · IPI00010080 · OXSR1_HUMAN · KIAA1101 · O95747)Serine/threonine-protein kinase OSR1⌘
H. sapiensENSEMBL:ENSG00000115694 · UniProtKB:O00506 (SOK1 · STK25 · O00506 · IPI00012093 · YSK1 · STK25_HUMAN)Serine/threonine-protein kinase 25⌘
H. sapiensENSEMBL:ENSG00000198648 · UniProtKB:Q9UEW8 (STK39 · SPAK · IPI00004363 · STK39_HUMAN · Q9UEW8)STE20/SPS1-related proline-alanine-rich protein kinase⌘
H. sapiensENSEMBL:ENSG00000104375 · UniProtKB:Q13188 (STK3_HUMAN · STK3 · Q13188 · IPI00411984 · MST2)Serine/threonine-protein kinase 3⌘
H. sapiensENSEMBL:ENSG00000101109 · UniProtKB:Q13043 (STK4_HUMAN · MST1 · STK4 · Q13043 · IPI00011488 · IPI00645585)Serine/threonine-protein kinase 4⌘
M. musculusUniProtKB:P31938 · MGI:MGI:1346866 (Prkmk1 · Mek1 · Map2k1)MAP kinase kinase 1 · mitogen-activated protein kinase kinase 1⌘
M. musculusUniProtKB:Q63932 · MGI:MGI:1346867 (Map2k2 · Prkmk2 · MEK2)MAP kinase/Erk kinase · mitogen-activated protein kinase kinase 2⌘
M. musculusUniProtKB:P47809 · MGI:MGI:1346869 (MKK4 · Map2k4 · Serk1 · Sek1 · JNKK1)mitogen-activated protein kinase kinase 4⌘
M. musculusUniProtKB:Q9WVS7 · MGI:MGI:1346345 (Mapkk5 · Prkmk5 · MEK5 · Map2k5)MAPK/ERK kinase 5 · mitogen-activated protein kinase kinase 5⌘
M. musculusUniProtKB:Q99JT2 · MGI:MGI:1917665 (2610018G03Rik)RIKEN cDNA 2610018G03 gene⌘
M. musculusUniProtKB:Q6P9R2 · MGI:MGI:1917378 (Osr1 · Oxsr1)oxidative-stress responsive 1⌘
M. musculusUniProtKB:Q9Z2W1 · MGI:MGI:1891699 (Ste20-like · Stk25 · Ysk1)serine/threonine kinase 25 (yeast)⌘
M. musculusUniProtKB:Q9Z1W9 · MGI:MGI:1858416 (SPAK · Stk39 · DCHT)serine/threonine kinase 39, STE20/SPS1 homolog (yeast)⌘
M. musculusUniProtKB:Q9JI10 · MGI:MGI:1928487 (mess1 · Mst2 · Stk3 · MST)serine/threonine kinase 3 (Ste20, yeast homolog)⌘
M. musculusUniProtKB:Q9JI11 · MGI:MGI:1929004 (Ysk3 · Mst1 · Stk4 · Kas-2)serine/threonine kinase 4⌘
R. norvegicusNCBI:XP_001070192 · RGD:1563568 (Mst4)serine/threonine protein kinase MST4⌘
R. norvegicusNCBI:XP_236687 · RGD:1310466 (Oxsr1)oxidative-stress responsive 1⌘
R. norvegicusUniProtKB:Q01986 · RGD:70495 (Map2k1)mitogen activated protein kinase kinase 1⌘
R. norvegicusUniProtKB:P36506 · RGD:61888 (Map2k2)mitogen activated protein kinase kinase 2⌘
R. norvegicusUniProtKB:Q62862 (IPI00230847 · Mek5 · Prkmk5 · Map2k5 · Mkk5 · IPI00209255 · MP2K5_RAT · Q62862 · IPI00230846) · RGD:61890 (Map2k5)Dual specificity mitogen-activated protein kinase kinase 5 · mitogen activated protein kinase kinase 5⌘⌘
R. norvegicusUniProtKB:O88506 · RGD:621643 (Stk39)serine/threonine kinase 39, STE20/SPS1 homolog (yeast)⌘
R. norvegicusUniProtKB:O54748 · RGD:68412 (Stk3)serine/threonine kinase 3 (STE20 homolog, yeast)⌘
R. norvegicusUniProtKB:Q4KSH6 · RGD:1307040 (Map2k4)mitogen activated protein kinase kinase 4⌘
R. norvegicusUniProtKB:Q6V9V9 · RGD:727809 (Stk25)serine/threonine kinase 25 (STE20 homolog, yeast)⌘
R. norvegicusNCBI:XP_001070199 · RGD:1312035 (Stk4)serine/threonine kinase 4⌘
S. cerevisiaeUniProtKB:P32490 · SGD:S000005757 (SSP32 · YOR231W · MKK1)Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity⌘
S. cerevisiaeUniProtKB:P32491 · SGD:S000006061 (LPI6 · MKK2 · SSP33 · YPL140C)Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity⌘
S. cerevisiaeUniProtKB:P08458 · SGD:S000002931 (YDR523C · SPS1)Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis⌘
S. cerevisiaeUniProtKB:P06784 · SGD:S000002318 (YDL159W · STE7)Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p⌘
S. pombeUniProtKB:P10506 · GeneDB_Spombe:SPAC1D4.13 (ste1 · SPAC1D4.13 · byr1 · ste3)MAP kinase kinase Byr1⌘
S. pombeUniProtKB:O14047 · GeneDB_Spombe:SPAC2C4.14c (SPAC2C4.14c · ppk11)PAK-related kinase Ppk11⌘
S. pombeUniProtKB:O14305 · GeneDB_Spombe:SPAC9G1.09 (SPAC9G1.09 · sid1)PAK-related kinase Sid1⌘
S. pombeUniProtKB:Q9Y884 · GeneDB_Spombe:SPBC543.07 (mkk1 · SPBC543.07 · pek1 · skh1)MAP kinase kinase Pek1⌘
S. pombeUniProtKB:P33886 · GeneDB_Spombe:SPBC409.07c (wis1 · smf2 · spc2 · SPBC409.07c)MAP kinase kinase Wis1⌘
ProteinPublicationCurator Notes
UniProtKB:P32490 · SGD:S000005757PMID:8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P32491 · SGD:S000006061PMID:8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P06784 · SGD:S000002318PMID:8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.The C. albicans protein HST7 complements a homologous mutation in S. cerevisiae.
UniProtKB:P06784 · SGD:S000002318PMID:16318282 Du H, et al. Cloning and characterization of a dual-specificity kinase gene in rice (Oryza sative). Yi Chuan Xue Bao. 2005 Nov;32(11):1167-75.The O. sativa protein OsSTY complements a homologous mutation in S. cerevisiae. This paper shows that O. sativa OsSTY serine/threonine/tyrosine kinase partially complements a yeast ste7 null mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000126934 · UniProtKB:P36507#115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME
ENSEMBL:ENSG00000126934 · UniProtKB:P36507#115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME
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