P-POD: Princeton Protein Orthology Database: GO3/Para1169

This family has 25 members: 5 Arabidopsis thaliana, 2 Caenorhabditis elegans, 3 Danio rerio, 2 Drosophila melanogaster, 3 Gallus gallus, 2 Homo sapiens, 3 Mus musculus, 3 Rattus norvegicus, 2 Saccharomyces cerevisiae.

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GO3/Para1169
25 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2171594 (AT5G47180 · MQL5.3 · MQL5_3) · NCBI:NP_851144.1⌘
A. thalianaNCBI:NP_567101.1 · TAIR:locus:2101766 ((AT)VAP · AT3G60600 · VAP27 · T4C21.10 · VAP · VAP27-1)VESICLE ASSOCIATED PROTEIN · VAMP/SYNAPTOBREVIN-ASSOCIATED PROTEIN 27-1⌘
A. thalianaNCBI:NP_567153.1 · TAIR:locus:2126921 (AT4G00170 · F6N15.21 · F6N15_21)⌘
A. thalianaNCBI:NP_179963.1 · TAIR:locus:2061461 (T29E15_3 · T29E15.3 · AT2G23830)⌘
A. thalianaNCBI:NP_182039.1 · TAIR:locus:2055557 (PVA12 · T14P1.5 · AT2G45140)PLANT VAP HOMOLOG 12⌘
C. elegansWB:WBGene00022546 (ZC196.2) · UniProtKB:O01630⌘
C. elegansWB:WBGene00018008 (F33D11.11 · vpr-1) · UniProtKB:O44782 (F33D11.11 · vpr-1)Major sperm protein⌘⌘
D. rerioUniProtKB:Q6DGS7 · ZFIN:ZDB-GENE-040718-281 (vapal)VAMP (vesicle-associated membrane protein)-associated protein A, like⌘
D. rerioUniProtKB:Q6P2B0 · ZFIN:ZDB-GENE-030131-2348 (vapb)vesicle-associated membrane protein, associated protein B and C⌘
D. rerioUniProtKB:Q6P0D4 · ZFIN:ZDB-GENE-030131-6540 (vapa)VAMP (vesicle-associated membrane protein)-associated protein A⌘
D. melanogasterFB:FBgn0028379 (fan · CG7919 · farinelli) · UniProtKB:Q9VSD3⌘
D. melanogasterUniProtKB:Q9W4N8 · FB:FBgn0029687 (l(1)G0231 · VAP33-A · vap-33A · dVAP33A · VAPB · anon-WO03040301.124 · BcDNA:GM03307 · CG5014 · anon-EST:Liang-2.42 · dVAP · DVAP-33A · VAP-33-1 · VAP-33 · Vap-33-1)clone 2.42⌘
G. gallusNCBI:XP_424031 · ENTREZ:426378
G. gallusUniProtKB:Q5F419 (RCJMB04_3m23 · Q5F419 · IPI00583274) · ENTREZ:768928⌘
G. gallusUniProtKB:Q5ZJJ3 (RCJMB04_17k23 · IPI00603449 · Q5ZJJ3) · ENTREZ:419317⌘
H. sapiensENSEMBL:ENSG00000101558 · UniProtKB:Q9P0L0 (Q9P0L0 · IPI00170692 · VAPA_HUMAN · VAP33 · VAPA)Vesicle-associated membrane protein-associated protein A⌘
H. sapiensENSEMBL:ENSG00000124164 · UniProtKB:O95292 (O95292 · VAPB_HUMAN · IPI00748221 · IPI00006211 · VAPB · UNQ484/PRO983)Vesicle-associated membrane protein-associated protein B/C⌘
M. musculusUniProtKB:Q9WV55 · MGI:MGI:1353561 (VAP33 · Vapa)vesicle-associated membrane protein, associated protein A · synaptobrevin-associated protein of 33kDa⌘
M. musculusUniProtKB:Q9QY76 · MGI:MGI:1928744 (VAP33b · D2Abb2e · Vapb)vesicle-associated membrane protein, associated protein B and C · VAMP-associated protein 33b⌘
M. musculusMGI:MGI:1919326 · UniProtKB:Q9D8A4
R. norvegicusUniProtKB:Q9Z270 · RGD:61803 (Vapa)VAMP (vesicle-associated membrane protein)-associated protein A⌘
R. norvegicusUniProtKB:Q9Z269 · RGD:68326 (Vapb)VAMP (vesicle-associated membrane protein)-associated protein B and C⌘
R. norvegicusNCBI:XP_001054144 · RGD:1304785
S. cerevisiaeUniProtKB:Q6Q595 · SGD:S000007228 (YBL091C-A · SCS22)Protein involved in regulation of phospholipid metabolism⌘
S. cerevisiaeUniProtKB:P40075 · SGD:S000000922 (SCS2 · YER120W)Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog⌘
ProteinPublicationCurator Notes
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein Q9P0L0 complements a homologous mutation in S. cerevisiae. This paper shows partial complementation of a yeast scs2 null mutant by H. sapiens VAP-A (Q9P0L0).
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein VAPA complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000124164 · UniProtKB:O95292#182980 SPINAL MUSCULAR ATROPHY, PROXIMAL, ADULT, AUTOSOMAL DOMINANTSPINAL MUSCULAR ATROPHY, LATE-ONSET, FINKEL TYPE, INCLUDED;;FINKEL LATE-ADULT TYPE SMA, INCLUDED
UniProtKB:P40075 · SGD:S000000922#608627 AMYOTROPHIC LATERAL SCLEROSIS 8; ALS8
SGD Disease Papers (2)
UniProtKB:P40075 · SGD:S000000922PMID:18468439 Lev S, et al. (2008) The VAP protein family: from cellular functions to motor neuron disease. Trends Cell Biol 18(6):282-90
PMID:15372378 Nishimura AL, et al. (2004) A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am J Hum Genet 75(5):822-31
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