P-POD: Princeton Protein Orthology Database: GO3/Para1033

This family has 29 members: 1 Arabidopsis thaliana, 2 Caenorhabditis elegans, 3 Danio rerio, 2 Dictyostelium discoideum, 3 Drosophila melanogaster, 3 Gallus gallus, 4 Homo sapiens, 4 Mus musculus, 3 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Para1033
29 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_566911.1 · TAIR:locus:2099478 (CDC2AAT · P34CDC2 · CDKA;1 · AT3G48750 · CDC2 · T21J18.20 · CDK2 · CDKA1 · CDC2A)CYCLIN-DEPENDENT KINASE A;1 · CELL DIVISION CONTROL 2⌘
C. elegansWB:WBGene00000405 (cdk-1 · T05G5.3) · UniProtKB:P34556 (cdk-1 · T05G5.3 · ncc-1 · CDC2_CAEEL)Cell division control protein 2 homolog⌘⌘
C. elegansWB:WBGene00000407 (T27E9.3 · cdk-5) · UniProtKB:O18142⌘
D. rerioUniProtKB:Q7T3L7 · ZFIN:ZDB-GENE-010320-1 (cdc2)cell division cycle 2⌘
D. rerioUniProtKB:Q7ZWB1 · ZFIN:ZDB-GENE-040426-2741 (cdk2)cyclin-dependent kinase 2⌘
D. rerioUniProtKB:Q9DE44 · ZFIN:ZDB-GENE-010131-2 (cdk5)cyclin-dependent protein kinase 5⌘
D. discoideumUniProtKB:P34112 · dictyBase:DDB_G0272813 (CAK · cdk1 · cdc2 · cdcB)p34-cdc2 protein, protein serine/threonine kinase, cyclin-dependent kinase, CDK family protein kinase, protein kinase, CMGC group, CDC2 subfamily protein kinase⌘
D. discoideumUniProtKB:P34117 · dictyBase:DDB_G0288677 (crpA · crp · cdk5)protein serine/threonine kinase, cyclin-dependent kinase, CDK family protein kinase, protein kinase, CMGC group⌘
D. melanogasterUniProtKB:P23573 · FB:FBgn0004107 (Dmcdc2c · DmCdk2 · Dcdc2c · CDC2c · cdk2 · CG10498 · S(Sev-CycE)3A · DmCdc2 · cdc2c · Cdc2c · CDK2 · CDK2/CDC2c · Cdk2)cyclin E-CDK2 · cyclin-dependent kinase 2⌘
D. melanogasterUniProtKB:P23572 · FB:FBgn0004106 (cdc2Dm · Cdc2 · CDK1/CDC2 · cdc · Dmcdc2 · l(2)31Eh · CDK1 · DmCdk1 · CDC2 · DmCdc2 · Dcdc2 · cdk1 · CG5363 · cdc2 · CDCDm · Cdk1)group 4 · cyclin dependent kinase · cyclin-dependent kinase 1 · cdc2 kinase · Dm cdc2 · Cdc2 kinase · CDC2 kinase⌘
D. melanogasterUniProtKB:P48609 · FB:FBgn0013762 (DmCdk5 · CG8203 · cdk5 · CDK5 · Cdk5)cyclin-dependent kinase 5 · Cyclin-dependent kinase 5⌘
G. gallusNCBI:NP_001129258 · ENTREZ:100190948
G. gallusENTREZ:396252 · UniProtKB:P13863 (P13863 · CDC2 · IPI00604039 · CDC2_CHICK)Cell division control protein 2 homolog⌘
G. gallusUniProtKB:A2IAR9 (A2IAR9 · CDK2 · IPI00589518) · ENTREZ:429642⌘
H. sapiensENSEMBL:ENSG00000170312 · UniProtKB:P06493 (CDC2 · P06493 · IPI00073536 · IPI00026689 · CDC2_HUMAN)Cell division control protein 2 homolog⌘
H. sapiensENSEMBL:ENSG00000123374 · UniProtKB:P24941 (CDK2_HUMAN · IPI00031681 · CDK2 · P24941)Cell division protein kinase 2⌘
H. sapiensENSEMBL:ENSG00000108504 · UniProtKB:Q00526 (CDK3 · IPI00023503 · Q00526 · CDK3_HUMAN)Cell division protein kinase 3⌘
H. sapiensENSEMBL:ENSG00000164885 · UniProtKB:Q00535 (CDK5 · IPI00023530 · CDK5_HUMAN · Q00535)Cell division protein kinase 5⌘
M. musculusUniProtKB:P11440 · MGI:MGI:88351 (Cdc2 · Cdc2a · p34 · CDK1)cell division cycle 2 homolog A (S. pombe)⌘
M. musculusUniProtKB:P97377 · MGI:MGI:104772 (Cdk2)cyclin-dependent kinase 2⌘
M. musculusUniProtKB:Q80YP0 · MGI:MGI:1916931 (Cdk3)cyclin-dependent kinase 3⌘
M. musculusUniProtKB:P49615 · MGI:MGI:101765 (Cdk5 · Crk6)cyclin-dependent kinase 5⌘
R. norvegicusUniProtKB:P39951 · RGD:2319 (Cdc2)cell division cycle 2, G1 to S and G2 to M⌘
R. norvegicusRGD:70486 (Cdk2) · UniProtKB:Q63699 (IPI00778415 · Cdk2 · CDK2_RAT · Q63699)cyclin dependent kinase 2 · Cell division protein kinase 2⌘⌘
R. norvegicusUniProtKB:Q03114 · RGD:70514 (Cdk5)cyclin-dependent kinase 5⌘
S. cerevisiaeUniProtKB:P00546 · SGD:S000000364 (SRM5 · HSL5 · YBR160W · CDC28 · CDK1)Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK)⌘
S. cerevisiaeUniProtKB:P17157 · SGD:S000005952 (phoU · YPL031C · PHO85 · LDB15)Cyclin-dependent kinase, with ten cyclin partners⌘
S. pombeUniProtKB:P04551 · GeneDB_Spombe:SPBC11B10.09 (SPBC11B10.09 · swo2 · cdc2)cyclin-dependent protein kinase Cdc2⌘
S. pombeUniProtKB:O74456 · GeneDB_Spombe:SPCC16C4.11 (SPCC16C4.11 · pef1)Pho85/PhoA-like cyclin-dependent kinase Pef1⌘
ProteinPublicationCurator Notes
UniProtKB:P00546 · SGD:S000000364PMID:1840925 Ferreira PC, et al. The Arabidopsis functional homolog of the p34cdc2 protein kinase. Plant Cell. 1991 May;3(5):531-40.The A. thaliana protein AT3G48750.1 complements a homologous mutation in S. cerevisiae. This paper shows that A. thaliana CDC2 partially complements an S. cerevisiae cdc28 mutant.
UniProtKB:P00546 · SGD:S000000364PMID:15965018 Corellou F, et al. Atypical regulation of a green lineage-specific B-type cyclin-dependent kinase. Plant Physiol. 2005 Jul;138(3):1627-36.The O. tauri protein CDKB complements a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:15093777 Takeo K, et al. Isolation of a CDC28 homologue from Cryptococcus neoformans that is able to complement cdc28 temperature-sensitive mutants of Saccharomyces cerevisiae. FEMS Yeast Res. 2004 May;4(7):737-44.The C. neoformans protein CnCdk1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:9803415 Vinkenoog R, et al. Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei. Mol Biochem Parasitol. 1998 Sep 15;95(2):229-40.The P. knowlesi protein CRK2 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:1714386 Elledge SJ, et al. A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. EMBO J. 1991 Sep;10(9):2653-9.The H. sapiens protein P24941 complements a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:12123447 Khan F, et al. Cyclin-dependent kinase TPK2 is a critical cell cycle regulator in Toxoplasma gondii. Mol Microbiol. 2002 Jul;45(2):321-32.The T. gondii protein TPK2 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:9803415 Vinkenoog R, et al. Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei. Mol Biochem Parasitol. 1998 Sep 15;95(2):229-40.The P. berghei protein CRK2 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P00546 · SGD:S000000364PMID:1714386 Elledge SJ, et al. A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. EMBO J. 1991 Sep;10(9):2653-9.The H. sapiens protein P06493 complements a homologous mutation in S. cerevisiae.
UniProtKB:P17157 · SGD:S000005952PMID:10567344 Nishizawa M, et al. Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, pho85 kinase. J Biol Chem. 1999 Nov 26;274(48):33859-62.The M. musculus protein A2A6E2 complements a homologous mutation in S. cerevisiae. Mouse Cdk5 (A2A6E2) partially complements a yeast pho85 null mutant.
UniProtKB:P00546 · SGD:S000000364PMID:17086156 Takeo K, et al. [Cell cycle control and CDC28/Cdc2 homologue and related gene cloning of Cryptococcus neoformans]. Nippon Ishinkin Gakkai Zasshi. 2006;47(4):257-62.The C. neoformans protein CnCdk1 complements a homologous mutation in S. cerevisiae. This paper shows that C. neoformans CnCdk1 complements S. cerevisiae cdc28-temperature sensitive mutants cdc28-4 and cdc28-1N. The article is in Japanese and therefore the curation was based on the abstract alone.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (3)
UniProtKB:P00546 · SGD:S000000364PMID:12705895 Kantham L, et al. (2003) Beacon interacts with cdc2/cdc28-like kinases. Biochem Biophys Res Commun 304(1):125-9
UniProtKB:P00546 · SGD:S000000364PMID:15364349 Semple JW and Duncker BP (2004) ORC-associated replication factors as biomarkers for cancer. Biotechnol Adv 22(8):621-31
PMID:12888290 Grim JE and Clurman BE (2003) Cycling without CDK2? Trends Cell Biol 13(8):396-9
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