P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL784

This family has 19 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 1 Drosophila melanogaster, 2 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/OrthoMCL784
19 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_187484.1 · TAIR:locus:2077843 (S6K2 · ATS6K2 · F17O14.19 · ATPK19 · ATPK2 · AT3G08720)ARABIDOPSIS THALIANA PROTEIN KINASE 2 · ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2 · Arabidopsis thaliana protein kinase 19⌘
A. thalianaNCBI:NP_187485.1 · TAIR:locus:2077873 (ATPK6 · ATS6K1 · S6K1 · PK1 · ATPK1 · F17O14.20 · PK6 · AT3G08730)ROTEIN-SERINE KINASE 6 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1 · PROTEIN-SERINE KINASE · P70 RIBOSOMAL S6 KINASE · PROTEIN-SERINE KINASE 1 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6⌘
C. elegansWB:WBGene00012929 (rsks-1 · Y47D3A.16) · UniProtKB:Q9NAH6⌘
D. rerioENSEMBL:ENSDARP00000012715
D. rerioUniProtKB:Q802Y7 · ZFIN:ZDB-GENE-040426-2038 (rps6kb1)ribosomal protein S6 kinase b, polypeptide 1⌘
D. melanogasterUniProtKB:P91656 · FB:FBgn0015806 (p70[S6K] · dp70[S6k] · p70[S6k] · dps6k · dp70s6k · dS6k · s6k11 · s6k · p70S6K · Dp70S6k · l(3)07084 · 7084 · CG10539 · S6k · DS6K · Dp70[s6k] · p70[S6kinase] · Dp70s6k · S6kinase · S6-kinase · ds6k · dS6K · p70/S6K · fs(3)07084 · S6K · p70s6K)p70 S6K · p70[S6 kinase] · RPS6-p70-protein kinase · dS6 kinase · p70 s6 kinase · S6 kinase⌘
G. gallusENTREZ:419166 · NCBI:XP_417346
G. gallusUniProtKB:Q5ZLW5 (IPI00579385 · RCJMB04_4j14 · Q5ZLW5) · ENTREZ:417637⌘
H. sapiensENSEMBL:ENSG00000108443 · UniProtKB:P23443 (IPI00216132 · STK14A · RPS6KB1 · IPI00759649 · KS6B1_HUMAN · P23443)Ribosomal protein S6 kinase beta-1⌘
H. sapiensENSEMBL:ENSG00000175634 · UniProtKB:Q9UBS0 (KS6B2_HUMAN · RPS6KB2 · Q9UBS0 · IPI00217069 · STK14B)Ribosomal protein S6 kinase beta-2⌘
H. sapiensENSEMBL:ENSG00000101049 · UniProtKB:Q9HBY8 (IPI00217154 · SGK2 · IPI00853438 · IPI00009887 · Q9HBY8 · SGK2_HUMAN)Serine/threonine-protein kinase Sgk2⌘
M. musculusUniProtKB:Q8BSK8 · MGI:MGI:1270849 (Rps6kb1 · p70s6k · S6K1 · p70/85s6k)ribosomal protein S6 kinase, polypeptide 1⌘
M. musculusUniProtKB:Q9Z1M4 · MGI:MGI:1927343 (S6K2 · Rps6kb2)ribosomal protein S6 kinase, polypeptide 2⌘
M. musculusUniProtKB:Q9QZS5 · MGI:MGI:1351318 (Sgk2)serum/glucocorticoid regulated kinase 2⌘
R. norvegicusUniProtKB:P67999 (Rps6kb1 · IPI00760127 · P67999 · KS6B1_RAT · IPI00471630) · RGD:620683 (Rps6kb1)Ribosomal protein S6 kinase beta-1 · ribosomal protein S6 kinase, 70kDa, polypeptide 1⌘⌘
R. norvegicusUniProtKB:Q8R4U9 · RGD:620232 (Sgk2)serum/glucocorticoid regulated kinase 2⌘
S. cerevisiaeUniProtKB:P12688 · SGD:S000001609 (SLI2 · YPK1 · YKL126W)Serine/threonine protein kinase required for receptor-mediated endocytosis⌘
S. cerevisiaeUniProtKB:P18961 · SGD:S000004710 (YPK2 · YMR104C · YKR2)Protein kinase with similarity to serine/threonine protein kinase Ypk1p⌘
S. pombeUniProtKB:Q9P7J8 · GeneDB_Spombe:SPCC24B10.07 (gad8 · SPCC24B10.07)serine/threonine protein kinase Gad8⌘
ProteinPublicationCurator Notes
UniProtKB:P12688 · SGD:S000001609PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P18961 · SGD:S000004710PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant.
UniProtKB:P12688 · SGD:S000001609PMID:20516150 Jacquier N, et al. Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids. J Cell Sci. 2010 Jul 1;123(Pt 13):2218-27.The H. sapiens protein SGK1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12688 · SGD:S000001609PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P18961 · SGD:S000004710PMID:10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97.The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (2)
UniProtKB:P18961 · SGD:S000004710PMID:18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
UniProtKB:P18961 · SGD:S000004710PMID:18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu