This family has 19 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 1 Drosophila melanogaster, 2 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_187484.1 · TAIR:locus:2077843 (S6K2 · ATS6K2 · F17O14.19 · ATPK19 · ATPK2 · AT3G08720) | ARABIDOPSIS THALIANA PROTEIN KINASE 2 · ARABIDOPSIS THALIANA SERINE/THREONINE PROTEIN KINASE 2 · Arabidopsis thaliana protein kinase 19 |  |
| A. thaliana | NCBI:NP_187485.1 · TAIR:locus:2077873 (ATPK6 · ATS6K1 · S6K1 · PK1 · ATPK1 · F17O14.20 · PK6 · AT3G08730) | ROTEIN-SERINE KINASE 6 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 1 · PROTEIN-SERINE KINASE · P70 RIBOSOMAL S6 KINASE · PROTEIN-SERINE KINASE 1 · ARABIDOPSIS THALIANA PROTEIN-SERINE KINASE 6 | |
| C. elegans | WB:WBGene00012929 (rsks-1 · Y47D3A.16) · UniProtKB:Q9NAH6 | | |
| D. rerio | ENSEMBL:ENSDARP00000012715 | ||
| D. rerio | UniProtKB:Q802Y7 · ZFIN:ZDB-GENE-040426-2038 (rps6kb1) | ribosomal protein S6 kinase b, polypeptide 1 | |
| D. melanogaster | UniProtKB:P91656 · FB:FBgn0015806 (p70[S6K] · dp70[S6k] · p70[S6k] · dps6k · dp70s6k · dS6k · s6k11 · s6k · p70S6K · Dp70S6k · l(3)07084 · 7084 · CG10539 · S6k · DS6K · Dp70[s6k] · p70[S6kinase] · Dp70s6k · S6kinase · S6-kinase · ds6k · dS6K · p70/S6K · fs(3)07084 · S6K · p70s6K) | p70 S6K · p70[S6 kinase] · RPS6-p70-protein kinase · dS6 kinase · p70 s6 kinase · S6 kinase | |
| G. gallus | ENTREZ:419166 · NCBI:XP_417346 | ||
| G. gallus | UniProtKB:Q5ZLW5 (IPI00579385 · RCJMB04_4j14 · Q5ZLW5) · ENTREZ:417637 | | |
| H. sapiens | ENSEMBL:ENSG00000108443 · UniProtKB:P23443 (IPI00216132 · STK14A · RPS6KB1 · IPI00759649 · KS6B1_HUMAN · P23443) | Ribosomal protein S6 kinase beta-1 | |
| H. sapiens | ENSEMBL:ENSG00000175634 · UniProtKB:Q9UBS0 (KS6B2_HUMAN · RPS6KB2 · Q9UBS0 · IPI00217069 · STK14B) | Ribosomal protein S6 kinase beta-2 | |
| H. sapiens | ENSEMBL:ENSG00000101049 · UniProtKB:Q9HBY8 (IPI00217154 · SGK2 · IPI00853438 · IPI00009887 · Q9HBY8 · SGK2_HUMAN) | Serine/threonine-protein kinase Sgk2 | |
| M. musculus | UniProtKB:Q8BSK8 · MGI:MGI:1270849 (Rps6kb1 · p70s6k · S6K1 · p70/85s6k) | ribosomal protein S6 kinase, polypeptide 1 | |
| M. musculus | UniProtKB:Q9Z1M4 · MGI:MGI:1927343 (S6K2 · Rps6kb2) | ribosomal protein S6 kinase, polypeptide 2 | |
| M. musculus | UniProtKB:Q9QZS5 · MGI:MGI:1351318 (Sgk2) | serum/glucocorticoid regulated kinase 2 | |
| R. norvegicus | UniProtKB:P67999 (Rps6kb1 · IPI00760127 · P67999 · KS6B1_RAT · IPI00471630) · RGD:620683 (Rps6kb1) | Ribosomal protein S6 kinase beta-1 · ribosomal protein S6 kinase, 70kDa, polypeptide 1 | |
| R. norvegicus | UniProtKB:Q8R4U9 · RGD:620232 (Sgk2) | serum/glucocorticoid regulated kinase 2 | |
| S. cerevisiae | UniProtKB:P12688 · SGD:S000001609 (SLI2 · YPK1 · YKL126W) | Serine/threonine protein kinase required for receptor-mediated endocytosis | |
| S. cerevisiae | UniProtKB:P18961 · SGD:S000004710 (YPK2 · YMR104C · YKR2) | Protein kinase with similarity to serine/threonine protein kinase Ypk1p | |
| S. pombe | UniProtKB:Q9P7J8 · GeneDB_Spombe:SPCC24B10.07 (gad8 · SPCC24B10.07) | serine/threonine protein kinase Gad8 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P12688 · SGD:S000001609 |  10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97. | The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant. | |
| UniProtKB:P18961 · SGD:S000004710 | 10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97. | The H. sapiens protein Q9HBY8 complements a homologous mutation in S. cerevisiae. A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant. | |
| UniProtKB:P12688 · SGD:S000001609 | 20516150 Jacquier N, et al. Ypk1, the yeast orthologue of the human serum- and glucocorticoid-induced kinase, is required for efficient uptake of fatty acids. J Cell Sci. 2010 Jul 1;123(Pt 13):2218-27. | The H. sapiens protein SGK1 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P12688 · SGD:S000001609 | 10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97. | The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P18961 · SGD:S000004710 | 10074427 Casamayor A, et al. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol. 1999 Feb 25;9(4):186-97. | The R. norvegicus protein Sgk1 complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (2) | |
|---|---|
| UniProtKB:P18961 · SGD:S000004710 | 18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80 |
| UniProtKB:P18961 · SGD:S000004710 | 18634833 Zabrocki P, et al. (2008) Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson. Biochim Biophys Acta 1783(10):1767-80 |