P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL75

This family has 69 members: 12 Arabidopsis thaliana, 2 Caenorhabditis elegans, 5 Danio rerio, 6 Dictyostelium discoideum, 3 Drosophila melanogaster, 7 Gallus gallus, 9 Homo sapiens, 10 Mus musculus, 9 Rattus norvegicus, 3 Saccharomyces cerevisiae, 3 Schizosaccharomyces pombe.

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GO3/OrthoMCL75
69 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2030180 (F28P22_11 · AT1G72700 · F28P22.11) · NCBI:NP_177414.1⌘
A. thalianaNCBI:NP_568146.1 · TAIR:locus:3355727 (ALA1 · AT5G04930)aminophospholipid ATPase1⌘
A. thalianaNCBI:NP_189189.1 · TAIR:locus:2102345 (T5M7.10 · AT3G25610)⌘
A. thalianaNCBI:NP_189425.1 · TAIR:locus:2086465 (K16N12.23 · AT3G27870)⌘
A. thalianaNCBI:NP_177038.1 · TAIR:locus:2026900 (F24J5.6 · F24J5_6 · AT1G68710)⌘
A. thalianaNCBI:NP_172780.1 · TAIR:locus:2031860 (F3F19.24 · ACA.l · F3F19_24 · AT1G13210)autoinhibited Ca2+/ATPase II⌘
A. thalianaNCBI:NP_173938.1 · TAIR:locus:2011420 (F28B23_19 · F28B23.19 · AT1G26130)⌘
A. thalianaNCBI:NP_175830.1 · TAIR:locus:2020038 (F20D21_10 · AT1G54280 · F20D21.10)⌘
A. thalianaNCBI:NP_188006.1 · TAIR:locus:2088217 (AT3G13900 · MDC16.2)⌘
A. thalianaNCBI:NP_176191.1 · TAIR:locus:2025961 (AT1G59820 · ALA3 · F23H11.14 · F23H11_14)Aminophospholipid ATPase3⌘
A. thalianaNCBI:NP_568633.1 · TAIR:locus:2167603 (MLN1_17 · AT5G44240 · MLN1.17)⌘
A. thalianaNCBI:NP_173193.2 · TAIR:locus:2007858 (AT1G17500 · F1L3.21 · F1L3_21)⌘
C. elegansWB:WBGene00019166 (tat-2 · H06H21.10) · UniProtKB:Q9TXV2⌘
C. elegansWB:WBGene00013034 (Y49E10.11 · tat-1) · UniProtKB:Q9U280⌘
D. rerioENSEMBL:ENSDARP00000070629
D. rerioENSEMBL:ENSDARP00000040283
D. rerioENSEMBL:ENSDARG00000062040 · UniProtKB:A2BGP2
D. rerioENSEMBL:ENSDARG00000042285 · UniProtKB:Q1LY58
D. rerioZFIN:ZDB-GENE-030616-51 · UniProtKB:Q7ZZ91
D. discoideumNCBI:EAL69686.1 · dictyBase:DDB_G0275871 (DDB_G0275871)phospholipid-translocating P-type ATPase family protein, transmembrane protein⌘
D. discoideumNCBI:EAL69518.1 · dictyBase:DDB_G0275535 (DDB_G0275535)phospholipid-translocating P-type ATPase family protein, transmembrane protein⌘
D. discoideumNCBI:EAL69224.1 · dictyBase:DDB_G0276541 (DDB_G0276541)P-type ATPase, transmembrane protein⌘
D. discoideumNCBI:EAL64003.1 · dictyBase:DDB_G0286891 (DDB_G0286891)P-type ATPase, transmembrane protein⌘
D. discoideumNCBI:EAL69268.1 · dictyBase:DDB_G0276375 (DDB_G0276375)phospholipid-translocating P-type ATPase family protein, transmembrane protein⌘
D. discoideumUniProtKB:Q55E61 · dictyBase:DDB_G0269380 (DDB_G0269380)P-type ATPase⌘
D. melanogasterFB:FBgn0033837 · UniProtKB:Q0E990
D. melanogasterUniProtKB:Q9VGD4 · FB:FBgn0037989 (CG14741)⌘
D. melanogasterFB:FBgn0030746 (CG9981) · UniProtKB:Q9VXG7⌘
G. gallusNCBI:XP_429208 · ENTREZ:431656
G. gallusNCBI:XP_422773 · ENTREZ:424964
G. gallusNCBI:XP_416948 · ENTREZ:418749
G. gallusNCBI:XP_420240 · ENTREZ:422254
G. gallusNCBI:XP_420729 · ENTREZ:422776
G. gallusNCBI:XP_425888 · ENTREZ:428328
G. gallusNCBI:XP_417130 · ENTREZ:418936
H. sapiensENSEMBL:ENSG00000068650 · UniProtKB:P98196 (AT11A_HUMAN · ATP11A · ATPIS · KIAA1021 · ATPIH · P98196 · IPI00255653)Probable phospholipid-transporting ATPase IH⌘
H. sapiensENSEMBL:ENSG00000058063 · UniProtKB:Q9Y2G3 (ATPIF · IPI00240793 · ATP11B · AT11B_HUMAN · Q9Y2G3 · KIAA0956 · ATPIR)Probable phospholipid-transporting ATPase IF⌘
H. sapiensENSEMBL:ENSG00000101974 · UniProtKB:Q8NB49 (Q8NB49 · AT11C_HUMAN · IPI00396234 · ATP11C · IPI00555989 · IPI00237446 · IPI00552319 · ATPIG · ATPIQ)Probable phospholipid-transporting ATPase IG⌘
H. sapiensENSEMBL:ENSG00000124406 · UniProtKB:Q9Y2Q0 (ATP8A1 · IPI00221038 · ATPIA · Q9Y2Q0 · AT8A1_HUMAN · IPI00032402)Probable phospholipid-transporting ATPase IA⌘
H. sapiensENSEMBL:ENSG00000132932 · UniProtKB:Q9NTI2 (AT8A2_HUMAN · IPI00465166 · Q9NTI2 · ATP8A2 · ATPIB · IPI00337792)Probable phospholipid-transporting ATPase IB⌘
H. sapiensENSEMBL:ENSG00000081923 · UniProtKB:O43520 (PFIC · AT8B1_HUMAN · IPI00012851 · ATPIC · ATP8B1 · FIC1 · O43520)Probable phospholipid-transporting ATPase IC⌘
H. sapiensENSEMBL:ENSG00000143515 · UniProtKB:P98198 (AT8B2_HUMAN · IPI00396074 · KIAA1137 · P98198 · ATPID · ATP8B2 · IPI00258027)Probable phospholipid-transporting ATPase ID⌘
H. sapiensENSEMBL:ENSG00000130270 · UniProtKB:O60423 (AT8B3_HUMAN · IPI00237913 · ATP1K · IPI00216974 · FOS37502_2 · ATP8B3 · O60423)Probable phospholipid-transporting ATPase IK⌘
H. sapiensENSEMBL:ENSG00000104043 · UniProtKB:Q8TF62 (ATP8B4 · Q8TF62 · AT8B4_HUMAN · IPI00152868 · KIAA1939)Probable phospholipid-transporting ATPase IM⌘
M. musculusNCBI:NP_083846 · MGI:MGI:1923545
M. musculusNCBI:NP_001074413 · MGI:MGI:1859664 (Im · Atp8b4)ATPase, class I, type 8B, member 4⌘
M. musculusNCBI:NP_080370 · MGI:MGI:1914581 (SAPLT · Atp8b3)ATPase, class I, type 8B, member 3⌘
M. musculusNCBI:NP_001001488 · MGI:MGI:1859665 (Ic · FIC1 · Atp8b1)ATPase, class I, type 8B, member 1⌘
M. musculusUniProtKB:P98197 · MGI:MGI:1354735 (Atp11a · Ih)ATPase, class VI, type 11A⌘
M. musculusUniProtKB:Q9QZW0 · MGI:MGI:1859661 (Atp11c · Ig)ATPase, class VI, type 11C⌘
M. musculusUniProtKB:P70704 · MGI:MGI:1330848 (Atp3a2 · Atp8a1)ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1⌘
M. musculusUniProtKB:P98200 · MGI:MGI:1354710 (Atp8a2 · Ib)ATPase, aminophospholipid transporter-like, class I, type 8A, member 2⌘
M. musculusUniProtKB:P98199 · MGI:MGI:1859660 (Atp8b2 · Id)ATPase, class I, type 8B, member 2⌘
M. musculusUniProtKB:A3FIN4 · MGI:MGI:2444287 (4930417M19Rik)RIKEN cDNA 4930417M19 gene⌘
R. norvegicusNCBI:XP_224270 · RGD:1561428
R. norvegicusNCBI:XP_001069520 · RGD:1592709 (LOC684238)similar to Probable phospholipid-transporting ATPase ID (ATPase class I type 8B member 2)⌘
R. norvegicusNCBI:XP_001076905 · RGD:1587460 (LOC691125)similar to Probable phospholipid-transporting ATPase ID (ATPase class I type 8B member 2)⌘
R. norvegicusNCBI:XP_223394 · RGD:1565036
R. norvegicusNCBI:XP_001070245 · RGD:1309619 (Atp8a1)ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1⌘
R. norvegicusNCBI:XP_001064261 · RGD:1308488 (Atp8b1)ATPase, Class I, type 8B, member 1⌘
R. norvegicusNCBI:XP_001062555 · RGD:1597731 (LOC685152)similar to Probable phospholipid-transporting ATPase ID (ATPase class I type 8B member 2)⌘
R. norvegicusNCBI:XP_001075555 · RGD:1308688 (Atp11a)ATPase, class VI, type 11A⌘
R. norvegicusNCBI:XP_234937 · RGD:1307622 (Atp8b3)ATPase, Class I, type 8B, member 3⌘
S. cerevisiaeUniProtKB:P39524 · SGD:S000000024 (FUN38 · DRS2 · SWA3 · YAL026C)Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles⌘
S. cerevisiaeUniProtKB:Q12675 · SGD:S000002500 (YDR093W · DNF2)Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane⌘
S. cerevisiaeUniProtKB:P32660 · SGD:S000000968 (DNF1 · YER166W)Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane⌘
S. pombeUniProtKB:Q09891 · GeneDB_Spombe:SPAC24B11.12c (SPAC24B11.12c)P-type ATPase⌘
S. pombeUniProtKB:O36028 · GeneDB_Spombe:SPAC4F10.16c (SPAC4F10.16c)P-type ATPase⌘
S. pombeUniProtKB:O94296 · GeneDB_Spombe:SPBC887.12 (SPBC887.12)P-type ATPase⌘
ProteinPublicationCurator Notes
UniProtKB:P39524 · SGD:S000000024PMID:11148289 Gomès E, et al. Chilling tolerance in Arabidopsis involves ALA1, a member of a new family of putative aminophospholipid translocases. Plant Cell. 2000 Dec;12(12):2441-2454.The A. thaliana protein AT5G67260.1 complements a homologous mutation in S. cerevisiae. A. thaliana CYCD3 (AT5G67260.1) is able to complement a yeast cln1 cln2 cln3 triple mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000081923 · UniProtKB:O43520#147480 CHOLESTASIS, INTRAHEPATIC, OF PREGNANCY; ICP;;RECURRENT INTRAHEPATIC CHOLESTASIS OF PREGNANCY; RICP;;CHOLESTASIS, PREGNANCY-RELATED
UniProtKB:P39524 · SGD:S000000024#243300 CHOLESTASIS, BENIGN RECURRENT INTRAHEPATIC, 1; BRIC1;;SUMMERSKILL SYNDROME
#211600 CHOLESTASIS, PROGRESSIVE FAMILIAL INTRAHEPATIC, 1; PFIC1;;BYLER DISEASE;;CHOLESTASIS, FATAL INTRAHEPATIC
SGD Disease Papers (1)
UniProtKB:P39524 · SGD:S000000024PMID:9500542 Bull LN, et al. (1998) A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18(3):219-24
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