P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL657

This family has 21 members: 1 Arabidopsis thaliana, 2 Escherichia coli, 11 Saccharomyces cerevisiae, 7 Schizosaccharomyces pombe.

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GO3/OrthoMCL657
21 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_563754.1 · TAIR:locus:2198861 (T21E18.1 · AT1G05940 · T21E18_1 · CAT9)CATIONIC AMINO ACID TRANSPORTER 9⌘
E. coliUniProtKB:P25737 · ECOLI:LYSP-MONOMER (LysP · cadR · lysP · ECK2149 · b2156)LysP lysine APC transporter⌘
E. coliUniProtKB:Q47689 · ECOLI:B0260-MONOMER (ECK0262 · mmuP · MmuP · ykfD · b0260)MmuP APC transporter⌘
S. cerevisiaeUniProtKB:P25376 · SGD:S000000530 (YCC5 · AGP1 · YCL025C)Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids⌘
S. cerevisiaeUniProtKB:P38971 · SGD:S000005214 (ALP1 · YNL270C · APL1)Arginine transporter⌘
S. cerevisiaeUniProtKB:P38084 · SGD:S000000272 (BAP2 · YBR068C)High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine⌘
S. cerevisiaeUniProtKB:P41815 · SGD:S000002453 (PAP1 · BAP3 · YDR046C)Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine⌘
S. cerevisiaeUniProtKB:P04817 · SGD:S000000789 (YEL063C · CAN1)Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts⌘
S. cerevisiaeUniProtKB:P19145 · SGD:S000001747 (YKR039W · GAP1)General amino acid permease⌘
S. cerevisiaeUniProtKB:P48813 · SGD:S000002916 (GNP1 · YDR508C)High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn⌘
S. cerevisiaeUniProtKB:P06775 · SGD:S000003423 (YGR191W · HIP1)High-affinity histidine permease, also involved in the transport of manganese ions⌘
S. cerevisiaeUniProtKB:P32487 · SGD:S000005212 (YNL268W · LYP1)Lysine permease⌘
S. cerevisiaeUniProtKB:P38967 · SGD:S000005380 (TAP2 · YOL020W · LTG3 · TAT2 · SAB2 · SCM2)High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance⌘
S. cerevisiaeUniProtKB:P38085 · SGD:S000000273 (TAP1 · YBR069C · TAT1 · VAP1)Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter⌘
S. pombeUniProtKB:P40901 · GeneDB_Spombe:SPAC1039.09 (SPAC1039.09 · isp5)amino acid permease Isp5⌘
S. pombeUniProtKB:O60170 · GeneDB_Spombe:SPBC19F8.06c (meu22 · SPBC19F8.06c)amino acid permease, unknown 11⌘
S. pombeUniProtKB:Q9P5N4 · GeneDB_Spombe:SPBC359.01 (SPBPB10D8.08 · SPBC359.01)amino acid permease, unknown 7⌘
S. pombeUniProtKB:Q9P5N2 · GeneDB_Spombe:SPBC359.03c (SPBC359.03c)amino acid permease, unknown 8⌘
S. pombeUniProtKB:Q9HDV2 · GeneDB_Spombe:SPBPB2B2.01 (SPBPB2B2.01)amino acid permease, unknown 12⌘
S. pombeUniProtKB:Q9URZ4 · GeneDB_Spombe:SPAC869.11 (cat1 · SPAC922.08c · SPAC869.11)cationic amino acid transporter Cat1⌘
S. pombeUniProtKB:Q9P768 · GeneDB_Spombe:SPAP7G5.06 (SPAP7G5.06)amino acid permease, unknown 4⌘
ProteinPublicationCurator Notes
UniProtKB:P19145 · SGD:S000001747PMID:12949183 Biswas S, et al. N-acetylglucosamine-inducible CaGAP1 encodes a general amino acid permease which co-ordinates external nitrogen source response and morphogenesis in Candida albicans. Microbiology. 2003 Sep;149(Pt 9):2597-608.The C. albicans protein CaGAP1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P19145 · SGD:S000001747PMID:15294814 Trip H, et al. Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease. Appl Environ Microbiol. 2004 Aug;70(8):4775-83.The P. chrysogenum protein PcGAP1 complements a homologous mutation in S. cerevisiae. P. chrysogenum PcGAP1 was overexpressed in an S. cerevisiae gap1 dip5 double mutant. P. chrysogenum PcGAP1 shows higher homology to the S. cerevisiae general amino acid permease GAP1 and the transport characteristics of PcGAP1 expressed in the double mutant indicate that it encodes the general amino acid permease of P. chrysogenum.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (3)
UniProtKB:P38967 · SGD:S000005380PMID:12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82
UniProtKB:P38085 · SGD:S000000273PMID:12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82
UniProtKB:P38085 · SGD:S000000273PMID:12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82
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