P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL606

This family has 21 members: 3 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 2 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 4 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

21 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2102554 (T5P19.140 · AT3G56490) · NCBI:NP_567038.1⌘
A. thalianaNCBI:NP_974907.1 · TAIR:locus:1006230576 (AT5G48545)⌘
A. thalianaNCBI:NP_174401.1 · TAIR:locus:2029559 (F28K20_9 · AT1G31160 · F28K20.9)⌘
C. elegansWB:WBGene00009002 (F21C3.3 · hint-1) · UniProtKB:P53795⌘
D. rerioUniProtKB:A3KP93 · ZFIN:ZDB-GENE-070410-139 (hint2)histidine triad nucleotide binding protein 2⌘
D. rerioZFIN:ZDB-GENE-040927-8 (zgc:103764) · UniProtKB:Q642J0⌘
D. discoideumUniProtKB:Q23921 · dictyBase:DDB_G0289391 (DD-1 · veg104 · rcdFF · pkiA)putative protein kinase C inhibitor, histidine triad (HIT) family protein⌘
D. discoideumUniProtKB:Q54HJ0 · dictyBase:DDB_G0289439 (DDB_G0289439)putative protein kinase C inhibitor, histidine triad (HIT) family protein⌘
D. melanogasterFB:FBgn0031459 (CG2862) · UniProtKB:Q8STA5⌘
E. coliUniProtKB:P0ACE7 · ECOLI:EG12172-MONOMER (b1103 · ECK1089 · ycfF · hinT · HinT)purine nucleoside phosphoramidase⌘
G. gallusENTREZ:395424 · UniProtKB:Q9I882 (chPKCI · IPI00578591 · Q9I882)⌘
H. sapiensENSEMBL:ENSG00000169567 · UniProtKB:P49773 (HINT1_HUMAN · PRKCNH1 · HINT · PKCI1 · HINT1 · IPI00239077 · P49773)Histidine triad nucleotide-binding protein 1⌘
H. sapiensENSEMBL:ENSG00000137133 · UniProtKB:Q9BX68 (HINT2_HUMAN · IPI00000335 · HINT2 · Q9BX68)Histidine triad nucleotide-binding protein 2⌘
M. musculusUniProtKB:P70349 · MGI:MGI:1321133 (PRKCNH1 · Ipk1 · PKCI-1 · Hint1)protein kinase C inhibitor 1 · PKC inhibitor/ interacting protein · histidine triad nucleotide binding protein 1⌘
M. musculusUniProtKB:Q9D0S9 · MGI:MGI:1916167 (Hint2)histidine triad nucleotide binding protein 2⌘
R. norvegicusNCBI:XP_001073678 · RGD:1593411 (Hint1)histidine triad nucleotide binding protein 1⌘
R. norvegicusNCBI:XP_001074494 · RGD:1307818
R. norvegicusNCBI:XP_233377 · RGD:1308910 (Hint2)histidine triad nucleotide binding protein 2⌘
R. norvegicusUniProtKB:P62959 · RGD:620960 (Hint1l)histidine triad nucleotide binding protein 1-like⌘
S. cerevisiaeUniProtKB:Q04344 · SGD:S000002283 (YDL125C · HNT1)Adenosine 5'-monophosphoramidase⌘
S. pombeUniProtKB:O94586 · GeneDB_Spombe:SPCC1442.14c (SPCC1442.14c)adenosine 5'-monophosphoramidase⌘
ProteinPublicationCurator Notes
UniProtKB:Q04344 · SGD:S000002283PMID:11805111 Bieganowski P, et al. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem. 2002 Mar 29;277(13):10852-60.The O. cuniculus protein Hint complements a homologous mutation in S. cerevisiae.
UniProtKB:Q04344 · SGD:S000002283PMID:22961002 Zimoń M, et al. Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia. Nat Genet. 2012 Oct;44(10):1080-3.The H. sapiens protein HINT1 complements a homologous mutation in S. cerevisiae.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:Q04344 · SGD:S000002283PMID:16964241 Ahel I, et al. (2006) The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443(7112):713-6
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