This family has 23 members: 4 Arabidopsis thaliana, 1 Caenorhabditis elegans, 3 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 3 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_200469.1 · TAIR:locus:2164981 (MIK19.2 · MIK19_2 · ATMKK6 · MKK6 · ANQ1 · AT5G56580) | ARABIDOPSIS NQK1 · MAP KINASE KINASE 6 · ARABIDOPSIS THALIANA MAP KINASE KINASE 6 |  |
| A. thaliana | NCBI:NP_198860.1 · TAIR:locus:2170578 (AT5G40440 · MPO12.150 · MPO12_150 · MKK3 · ATMKK3) | ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 · MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 | |
| A. thaliana | NCBI:NP_001031751.1 · TAIR:locus:2123909 (MKK2 · AT4G29810 · F27B13_50 · MK1 · F27B13.50 · ATMKK2) | MAP KINASE KINASE 1 · ARABIDOPSIS THALIANA MAP KINASE KINASE 2 · MAP KINASE KINASE 2 | |
| A. thaliana | NCBI:NP_194337.1 · TAIR:locus:2120855 (F20B18.180 · ATMEK1 · MEK1 · AT4G26070 · MKK1 · NMAPKK · F20B18_180) | MAP KINASE/ ERK KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE | |
| C. elegans | WB:WBGene00003186 (Y54E10BL.6 · mek-2) · UniProtKB:Q10664 | | |
| D. rerio | ENSEMBL:ENSDARP00000090612 | ||
| D. rerio | UniProtKB:Q1LUY7 · ZFIN:ZDB-GENE-040426-2759 (map2k1) | mitogen-activated protein kinase kinase 1 | |
| D. rerio | UniProtKB:Q1LY62 · ZFIN:ZDB-GENE-041027-1 (map2k2) | mitogen-activated protein kinase kinase 2 | |
| D. discoideum | UniProtKB:Q55CL6 · dictyBase:DDB_G0269152 (DdMEK1 · mekA · mek1) | MAP kinase kinase (MAP2K), STE7 family protein kinase, protein kinase, STE group | |
| D. melanogaster | UniProtKB:Q24324 · FB:FBgn0010269 (D-mek · D-sor · MEK1/2 · D-sor-1 · D-Mek · Su(Raf)34B · D-MEK/Dsor · Sor · MEK · dMEK · D-MEK · Dsor1 · D-SOR · MEK/Dsor1 · MAPKK · CG15793 · EK1-1 · DSORT · DSor1 · DSor · Dsor · sor · dsor1 · Dmek · D-Sor · DRODSOR1 · mek · SOR · Mek · dSor · DSOR1 · DMEK-1 · sor/MEK1) | Map kinase kinase · Downstream of raf1 · MAPK kinase · downstream suppressor of Raf 1 · Drosophila MEK | |
| G. gallus | ENTREZ:396349 · UniProtKB:Q90891 (IPI00596185 · MKK2 · MAP2K2 · PRKMK2 · Q90891 · MP2K2_CHICK · MEK2) | Dual specificity mitogen-activated protein kinase kinase 2 | |
| G. gallus | UniProtKB:Q5ZIF0 (RCJMB04_27f19 · IPI00580271 · Q5ZIF0) · ENTREZ:415549 | | |
| H. sapiens | ENSEMBL:ENSG00000169032 · UniProtKB:Q02750 (IPI00219604 · PRKMK1 · MEK1 · Q02750 · MP2K1_HUMAN · MAP2K1) | Dual specificity mitogen-activated protein kinase kinase 1 | |
| H. sapiens | ENSEMBL:ENSG00000126934 · UniProtKB:P36507 (MP2K2_HUMAN · IPI00003783 · MKK2 · P36507 · MAP2K2 · PRKMK2 · MEK2) | Dual specificity mitogen-activated protein kinase kinase 2 | |
| M. musculus | UniProtKB:P31938 · MGI:MGI:1346866 (Prkmk1 · Mek1 · Map2k1) | MAP kinase kinase 1 · mitogen-activated protein kinase kinase 1 | |
| M. musculus | UniProtKB:Q63932 · MGI:MGI:1346867 (Map2k2 · Prkmk2 · MEK2) | MAP kinase/Erk kinase · mitogen-activated protein kinase kinase 2 | |
| R. norvegicus | UniProtKB:Q01986 · RGD:70495 (Map2k1) | mitogen activated protein kinase kinase 1 | |
| R. norvegicus | UniProtKB:P36506 · RGD:61888 (Map2k2) | mitogen activated protein kinase kinase 2 | |
| S. cerevisiae | UniProtKB:P32490 · SGD:S000005757 (SSP32 · YOR231W · MKK1) | Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity | |
| S. cerevisiae | UniProtKB:P32491 · SGD:S000006061 (LPI6 · MKK2 · SSP33 · YPL140C) | Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity | |
| S. cerevisiae | UniProtKB:P08018 · SGD:S000003664 (HOG4 · YJL128C · SSK4 · SFS4 · PBS2) | MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress | |
| S. pombe | UniProtKB:P10506 · GeneDB_Spombe:SPAC1D4.13 (ste1 · SPAC1D4.13 · byr1 · ste3) | MAP kinase kinase Byr1 | |
| S. pombe | UniProtKB:Q9Y884 · GeneDB_Spombe:SPBC543.07 (mkk1 · SPBC543.07 · pek1 · skh1) | MAP kinase kinase Pek1 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P08018 · SGD:S000003664 |  15707964 Sharma P, et al. Evidence that C-terminal non-kinase domain of Pbs2p has a role in high osmolarity-induced nuclear localization of Hog1p. Biochem Biophys Res Commun. 2005 Mar 25;328(4):906-13. | The D. hansenii protein DPBS2 complements a homologous mutation in S. cerevisiae. This paper shows that D. hansenii DPBS2 partially complements a yeast pbs2 null mutant. | |
| UniProtKB:P32490 · SGD:S000005757 | 8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21. | The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested. | |
| UniProtKB:P32491 · SGD:S000006061 | 8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21. | The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested. | |
| UniProtKB:P08018 · SGD:S000003664 | 8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21. | The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested. | |
| UniProtKB:P08018 · SGD:S000003664 | 17349032 Lenassi M, et al. The MAP kinase HwHog1 from the halophilic black yeast Hortaea werneckii: coping with stresses in solar salterns. Saline Systems. 2007;3:3. | The H. werneckii protein HwHOG1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of H. werneckii HwHOG1 in an S. cerevisiae pbs2 null mutant. | |
| UniProtKB:P08018 · SGD:S000003664 | 12704083 Soyano T, et al. NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis. Genes Dev. 2003 Apr 15;17(8):1055-67. | The N. tabacum protein NQK1 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P08018 · SGD:S000003664 | 15882418 Furukawa K, et al. Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress. Mol Microbiol. 2005 Jun;56(5):1246-61. | The A. nidulans protein pbsB complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (2) | |
|---|---|
| ENSEMBL:ENSG00000126934 · UniProtKB:P36507 | #115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME |
| ENSEMBL:ENSG00000126934 · UniProtKB:P36507 | #115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME |