P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL5066

This family has 8 members: 7 Escherichia coli, 1 Saccharomyces cerevisiae.

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GO3/OrthoMCL5066
8 members.
OrganismProtein (Synonyms)DescriptionAmiGO
E. coliUniProtKB:P0AEX3 · ECOLI:KGTP-MONOMER (ECK2585 · kgtP · KgtP · witA · b2587)KgtP alpha-ketoglutarate MFS transporter⌘
E. coliUniProtKB:P41036 · ECOLI:NANT-MONOMER (b3224 · ECK3213 · NanT · nanT)NanT sialic acid MFS transporter⌘
E. coliUniProtKB:P0C0L7 · ECOLI:PROP-MONOMER (B4111 · proP · ProP · b4111 · ECK4104)proline/glycine betaine transporter · ProP proline/betaine MFS transporter⌘
E. coliUniProtKB:P76350 · ECOLI:SHIA-MONOMER (ECK1976 · shiA · b1981 · yeeM · ShiA)ShiA shikimate MFS transporter⌘
E. coliUniProtKB:P77228 · ECOLI:B1543-MONOMER (YdfJ · ECK1536 · ydfJ · b1543)predicted transporter⌘
E. coliUniProtKB:P37643 · ECOLI:YHJE-MONOMER (b3523 · YhjE · ECK3508 · yhjE)YhjE MFS transporter⌘
E. coliUniProtKB:P39352 · ECOLI:YJHB-MONOMER (ECK4269 · YjhB · yjhB · b4279)YjhB MFS transporter⌘
S. cerevisiaeUniProtKB:P36035 · SGD:S000001700 (YKL217W · JEN1)Lactate transporter, required for uptake of lactate and pyruvate⌘
ProteinPublicationCurator Notes
UniProtKB:P36035 · SGD:S000001700PMID:12962538 Soares-Silva I, et al. Functional expression of the lactate permease Jen1p of Saccharomyces cerevisiae in Pichia pastoris. Biochem J. 2003 Dec 15;376(Pt 3):781-7.The S. cerevisiae protein JEN1 was expressed in P. pastoris, but complementation was not directly tested. This paper describes expression of Jen1p in P. pastoris.
UniProtKB:P36035 · SGD:S000001700PMID:15450186 Makuc J, et al. Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces cerevisiae. FEMS Yeast Res. 2004 Sep;4(8):795-801.The R. norvegicus protein MCT1 complements a homologous mutation in S. cerevisiae. Rat MCT1 complements deletion of JEN1 in a jen1 mae1 cdc19 mutant.
UniProtKB:P36035 · SGD:S000001700PMID:15450186 Makuc J, et al. Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces cerevisiae. FEMS Yeast Res. 2004 Sep;4(8):795-801.The R. norvegicus proteins Slc16a1 and Mct1 complement a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (1)
UniProtKB:P36035 · SGD:S000001700PMID:10510291 Halestrap AP and Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343 Pt 2:281-99
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