P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL4744

This family has 9 members: 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

9 members.
OrganismProtein (Synonyms)DescriptionAmiGO
C. elegansWB:WBGene00009010 (F21D5.5) · UniProtKB:Q19683⌘
D. rerioZFIN:ZDB-GENE-061013-433 (zgc:153084) · UniProtKB:Q08BP0⌘
D. discoideumUniProtKB:Q54U78 · dictyBase:DDB_G0281229 (PNKP · PNK)SAP DNA-binding domain-containing protein, putative bifunctional polynucleotide phosphatase/kinase⌘
D. melanogasterUniProtKB:Q8MZ20 · FB:FBgn0037578
H. sapiensENSEMBL:ENSG00000039650 · UniProtKB:Q96T60 (PNKP_HUMAN · Q96T60 · PNKP · IPI00290684)Bifunctional polynucleotide phosphatase/kinase⌘
M. musculusUniProtKB:Q9JLV6 · MGI:MGI:1891698 (PNK · Pnkp)polynucleotide kinase 3'- phosphatase⌘
R. norvegicusUniProtKB:Q6AXV0 · RGD:1303331 (Pnkp)polynucleotide kinase 3'-phosphatase⌘
S. cerevisiaeUniProtKB:Q03796 · SGD:S000004765 (YMR156C · TPP1)DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks⌘
S. pombeUniProtKB:O13911 · GeneDB_Spombe:SPAC23C11.04c (pnk1 · SPAC23C11.04c)DNA kinase/phosphatase Pnk1⌘
ProteinPublicationCurator Notes
UniProtKB:Q03796 · SGD:S000004765PMID:12783866 Karumbati AS, et al. The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions. J Biol Chem. 2003 Aug 15;278(33):31434-43.The S. cerevisiae protein TPP1 was expressed in E. coli, but complementation was not directly tested. This paper shows that yeast TPP1 can confer resistance to methylmethane sulfonate when expressed in bacteria that lack abasic endonuclease/3'-phosphodiesterase function.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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