This family has 27 members: 7 Arabidopsis thaliana, 1 Caenorhabditis elegans, 3 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Gallus gallus, 3 Homo sapiens, 3 Mus musculus, 3 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_567504.1 · TAIR:locus:2130759 (DL4285C · FCAALL.383 · AT4G16520 · ATG8F) | autophagy 8f |  |
| A. thaliana | NCBI:NP_001078424.1 · TAIR:locus:2120618 (APG8A · ATG8A · F1N20.80 · F1N20_80 · AT4G21980) | AUTOPHAGY-RELATED 8A · AUTOPHAGY 8A | |
| A. thaliana | NCBI:NP_192371.1 · TAIR:locus:2125791 (F4H6.14 · ATG8B · AT4G04620 · F4H6_14) | autophagy 8b | |
| A. thaliana | NCBI:NP_182042.2 · TAIR:locus:2055537 (T14P1.2 · ATG8E · AtATG8e · AT2G45170) | autophagy 8e | |
| A. thaliana | NCBI:NP_176395.1 · TAIR:locus:2036853 (AT1G62040 · F8K4.23 · ATG8C · F8K4_23) | autophagy 8c | |
| A. thaliana | NCBI:NP_191623.1 · TAIR:locus:2101816 (ATG8G · AT3G60640 · T4C21.50) | AUTOPHAGY 8G | |
| A. thaliana | NCBI:NP_178631.1 · TAIR:locus:2058939 (ATG8D · T20G20.2 · T20G20_2 · AT2G05630) | | |
| C. elegans | WB:WBGene00002980 (lgg-1 · C32D5.9) · UniProtKB:Q09490 (lgg-1 · LGG1_CAEEL · C32D5.9) | Protein lgg-1 | |
| D. rerio | ENSEMBL:ENSDARP00000068351 | ||
| D. rerio | ZFIN:ZDB-GENE-030131-5174 · UniProtKB:Q6NZZ7 | ||
| D. rerio | UniProtKB:Q6TH05 · ZFIN:ZDB-GENE-040718-336 (gabarapl2) | GABA(A) receptor-associated protein-like 2 | |
| D. discoideum | UniProtKB:Q86CR8 · dictyBase:DDB_G0286191 (atg8 · APG8) | autophagy protein 8 | |
| D. melanogaster | FB:FBgn0038539 · UniProtKB:Q7K1J3 | ||
| D. melanogaster | UniProtKB:Q9W2S2 · FB:FBgn0052672 (atg8 · CG32672 · DrAtg8a · BcDNA:LD05816 · atg8a · Atg8a · CG1534 · ATG8a · Atg8/LC3) | Autophagy-specific gene 8a | |
| G. gallus | NCBI:XP_001231888 · ENTREZ:769118 | ||
| G. gallus | NCBI:XP_001232689 · ENTREZ:770240 | ||
| H. sapiens | ENSEMBL:ENSG00000170296 · UniProtKB:O95166 (IPI00027253 · HT004 · O95166 · GABARAP · GBRAP_HUMAN · FLC3B) | Gamma-aminobutyric acid receptor-associated protein | |
| H. sapiens | ENSEMBL:ENSG00000034713 · UniProtKB:P60520 (GABARAPL2 · IPI00026358 · P60520 · FLC3A · GBRL2_HUMAN · GEF2) | Gamma-aminobutyric acid receptor-associated protein-like 2 | |
| H. sapiens | ENSEMBL:ENSG00000139112 · UniProtKB:Q9BY60 (GBRL3_HUMAN · Q9BY60 · IPI00000252 · GABARAPL3) | Gamma-aminobutyric acid receptor-associated protein-like 3 | |
| M. musculus | UniProtKB:Q9DCD6 · MGI:MGI:1861742 (Gabarap) | gamma-aminobutyric acid receptor associated protein | |
| M. musculus | UniProtKB:Q8R3R8 · MGI:MGI:1914980 (GECI · Apg8l · Gabarapl1) | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 | |
| M. musculus | UniProtKB:P60521 · MGI:MGI:1890602 (Gabarapl2 · GATE-16 · Gef2) | gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 | |
| R. norvegicus | UniProtKB:P60517 · RGD:61911 (Gabarap) | GABA(A) receptor-associated protein | |
| R. norvegicus | UniProtKB:Q0VGK0 · RGD:1596143 (Gabarapl1) | GABA(A) receptor-associated protein like 1 | |
| R. norvegicus | UniProtKB:P60522 · RGD:620510 (Gabarapl2) | GABA(A) receptor-associated protein like 2 | |
| S. cerevisiae | UniProtKB:P38182 · SGD:S000000174 (CVT5 · YBL078C · AUT7 · APG8 · ATG8) | Component of autophagosomes and Cvt vesicles | |
| S. pombe | UniProtKB:O94272 · GeneDB_Spombe:SPBP8B7.24c (atg8 · SPBP8B7.24c) | autophagy associated protein Atg8 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P38182 · SGD:S000000174 |  15178341 Ketelaar T, et al. Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins. FEBS Lett. 2004 Jun 4;567(2-3):302-6. | The A. thaliana protein AT4G21980.1 complements a homologous mutation in S. cerevisiae. A. thaliana has eight homologs of yeast ATG8. This gene, AtAtg8a, is one of two tested and shown in this paper to complement a yeast atg8 mutant. | |
| UniProtKB:P38182 · SGD:S000000174 | 15178341 Ketelaar T, et al. Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins. FEBS Lett. 2004 Jun 4;567(2-3):302-6. | The A. thaliana protein AT2G05630.1 complements a homologous mutation in S. cerevisiae. A. thaliana has eight homologs of yeast ATG8. This gene, AtAtg8d, is one of two tested and shown in this paper to complement a yeast atg8 mutant. | |
| UniProtKB:P38182 · SGD:S000000174 | 10837468 Legesse-Miller A, et al. Aut7p, a soluble autophagic factor, participates in multiple membrane trafficking processes. J Biol Chem. 2000 Oct 20;275(42):32966-73. | The S. cerevisiae protein ATG8 was expressed in E. coli, but complementation was not directly tested. Recombinant yeast Atg8p was produced in E. coli and used in an assay to demonstrate that it is a functional homologue of mammalian GATE-16. | |
| UniProtKB:P38182 · SGD:S000000174 | 15277523 Ichimura Y, et al. In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem. 2004 Sep 24;279(39):40584-92. | The S. cerevisiae protein ATG8 was expressed in E. coli, but complementation was not directly tested. Yeast Atg8p, Atg7p and Atg3p were coexpressed in E. coli to study the reconstitution of atg8 conjugation essential for autophagy. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (2) | |
|---|---|
| UniProtKB:P38182 · SGD:S000000174 | 15884975 Jackson WT, et al. (2005) Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol 3(5):e156 |
| UniProtKB:P38182 · SGD:S000000174 | 16740722 Herman-Antosiewicz A, et al. (2006) Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res 66(11):5828-35 |