P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL346

This family has 28 members: 4 Arabidopsis thaliana, 4 Caenorhabditis elegans, 4 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Gallus gallus, 3 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 3 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL346
28 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2161083 (MCD7_21 · AT5G56450 · MCD7.21) · NCBI:NP_200456.1⌘
A. thalianaNCBI:NP_196853.1 · TAIR:locus:2185041 (T6I14_20 · T6I14.20 · AT5G13490 · AAC2)ADP/ATP carrier 2⌘
A. thalianaNCBI:NP_187470.1 · TAIR:locus:2077778 (AAC1 · AT3G08580 · F17O14.5)ADP/ATP CARRIER 1⌘
A. thalianaNCBI:NP_194568.1 · TAIR:locus:2121363 (F20O9_60 · AAC3 · AT4G28390 · ATAAC3 · F20O9.60)ADP/ATP CARRIER 3⌘
C. elegansWB:WBGene00007057 (W02D3.6 · ant-1.2) · UniProtKB:O01813⌘
C. elegansWB:WBGene00006439 (ant-1.1 · T27E9.1) · UniProtKB:O45865 (ant-1.1 · T27E9.1 · tag-61 · T27E9.1a)Protein T27E9.1a, confirmed by transcript evidence⌘⌘
C. elegansWB:WBGene00020140 (T01B11.4 · ant-1.4) · UniProtKB:P91410⌘
C. elegansWB:WBGene00010485 (ant-1.3 · K01H12.2) · UniProtKB:Q21103⌘
D. rerioENSEMBL:ENSDARP00000022077
D. rerioUniProtKB:Q6NX10 · ZFIN:ZDB-GENE-030131-5275 (slc25a4)solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4⌘
D. rerioENSEMBL:ENSDARG00000071483 · UniProtKB:Q8JHI0
D. rerioUniProtKB:Q8JHI0 · ENSEMBL:ENSDARG00000071480
D. discoideumUniProtKB:O97470 · dictyBase:DDB_G0267454 (ancA · ANT · slc25a4)ADP/ATP translocase, mitochondrial substrate carrier family protein, transmembrane protein⌘
D. melanogasterUniProtKB:Q26365 · FB:FBgn0003360 (l(1)9Ed · l(1)G0247 · jive · EM12 · A/A-T/sesB · dANT · l(1)EM31 · l(1)9Fa · l(1)G0126 · S12 · A/A-T · l(1)DC701 · ADT2 · Hmr · anon-WO02059370.55 · orangi · CG16944 · l(1)S12 · l(1)G0386 · ANT · sesB · lethal(1)9Ed)stress sensitive B · Adenine nucleotide translocase · stress-sensitive B · ses B · Drosophila ANT · ADP/ATP translocase⌘
D. melanogasterUniProtKB:O62526 · FB:FBgn0025111 (l(1)G0126 · l(1)G0247 · CG1683 · l(1)G0386 · Ant2)ADP/ATP translocase. · Adenine nucleotide translocase 2⌘
G. gallusUniProtKB:Q5ZLG7 (Q5ZLG7 · IPI00600989 · RCJMB04_6e4) · ENTREZ:374072⌘
G. gallusUniProtKB:Q5ZMJ6 (IPI00581512 · Q5ZMJ6 · RCJMB04_1n4) · ENTREZ:422546⌘
H. sapiensENSEMBL:ENSG00000151729 · UniProtKB:P12235 (IPI00022891 · SLC25A4 · ADT1_HUMAN · ANT1 · P12235)ADP/ATP translocase 1⌘
H. sapiensENSEMBL:ENSG00000005022 · UniProtKB:P05141 (P05141 · IPI00007188 · ADT2_HUMAN · ANT2 · SLC25A5)ADP/ATP translocase 2⌘
H. sapiensENSEMBL:ENSG00000169100 · UniProtKB:P12236 (CDABP0051 · P12236 · IPI00291467 · ADT3_HUMAN · ANT3 · SLC25A6)ADP/ATP translocase 3⌘
M. musculusUniProtKB:P48962 · MGI:MGI:1353495 (Slc25a4 · Ant1)adenine nucleotide translocase-1 · solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4⌘
M. musculusUniProtKB:P51881 · MGI:MGI:1353496 (Slc25a5 · Ant2)adenine nucleotide translocase · solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5⌘
R. norvegicusUniProtKB:Q05962 · RGD:620352 (Slc25a4)solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4⌘
R. norvegicusUniProtKB:Q09073 · RGD:620353 (Slc25a5)solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5⌘
S. cerevisiaeUniProtKB:P04710 · SGD:S000004660 (YMR056C · AAC1)Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP⌘
S. cerevisiaeUniProtKB:P18239 · SGD:S000000126 (PET9 · OP1 · YBL030C · AAC2 · ANC2)Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP⌘
S. cerevisiaeUniProtKB:P18238 · SGD:S000000289 (AAC3 · YBR085W · ANC3)Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP⌘
S. pombeUniProtKB:Q09188 · GeneDB_Spombe:SPBC530.10c (anc1 · SPBC530.10c)mitochondrial adenine nucleotide carrier Anc1⌘
ProteinPublicationCurator Notes
UniProtKB:P18239 · SGD:S000000126PMID:8675018 Couzin N, et al. Cloning of the gene encoding the mitochondrial adenine nucleotide carrier of Schizosaccharomyces pombe by functional complementation in Saccharomyces cerevisiae. Gene. 1996 May 24;171(1):113-7.The S. pombe protein ANC complements a homologous mutation in S. cerevisiae.
UniProtKB:P18239 · SGD:S000000126PMID:7736606 Viola AM, et al. A kluyveromyces lactis gene homologue to AAC2 complements the Saccaromyces cerevisiae op1 mutation. Curr Genet. 1995 Feb;27(3):229-33.The K. lactis protein KIAAC complements a homologous mutation in S. cerevisiae.
UniProtKB:P18239 · SGD:S000000126PMID:15688220 Mentel M, et al. Triplicate genes for mitochondrial ADP/ATP carriers in the aerobic yeast Yarrowia lipolytica are regulated differentially in the absence of oxygen. Mol Genet Genomics. 2005 Mar;273(1):84-91.The Y. lipolytica protein YlAAC1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000151729 · UniProtKB:P12235+103220 SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDETRANSLOCATOR), MEMBER 4; SLC25A4;;ADENINE NUCLEOTIDE TRANSLOCATOR 1; ANT1;;ADP/ATP TRANSLOCATOR OF SKELETAL MUSCLE; ANT;;ADP/ATP TRANSLOCASE 1;;ADP/ATP CARRIER 1; AAC1ADENINE NUCLEOTIDE TRANSLOCATOR DEFICIENCY, INCLUDED
UniProtKB:P18239 · SGD:S000000126#609283 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS,AUTOSOMAL DOMINANT, 2;;PEOA2;;PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA, AUTOSOMAL DOMINANT, 2
SGD Disease Papers (6)
UniProtKB:P18239 · SGD:S000000126PMID:19160490 Wang X, et al. (2008) Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol 10(9):1090-7
PMID:18809618 Wang X, et al. (2008) Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases. Hum Mol Genet 17(24):4036-44
PMID:18690234 Wang X, et al. (2008) Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol
PMID:16438935 Lodi T, et al. (2006) Mutation D104G in ANT1 gene: complementation study in Saccharomyces cerevisiae as a model system. Biochem Biophys Res Commun 341(3):810-5
PMID:16155110 Palmieri L, et al. (2005) Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy. Hum Mol Genet 14(20):3079-88
PMID:15016764 Fontanesi F, et al. (2004) Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability. Hum Mol Genet 13(9):923-34
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