This family has 11 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | TAIR:locus:2168833 (MNF13.22 · MNF13_22 · AT5G40660) · NCBI:NP_198882.1 |  | |
| C. elegans | WB:WBGene00013804 (Y116A8C.27) · UniProtKB:Q9U2U3 | | |
| D. rerio | ENSEMBL:ENSDARG00000056270 · UniProtKB:A3KP55 | ||
| D. discoideum | dictyBase:DDB_G0292678 · UniProtKB:Q54CV4 | ||
| D. melanogaster | UniProtKB:Q8T3M6 · FB:FBgn0021856 (l(2)k14505 · CG8674) | lethal (2) k14505 | |
| G. gallus | NCBI:XP_414815 · ENTREZ:416511 | ||
| H. sapiens | ENSEMBL:ENSG00000171953 · UniProtKB:Q8N5M1 (LP3663 · Q8N5M1 · ATP12 · ATPF2_HUMAN · IPI00296999 · ATPAF2) | ATP synthase mitochondrial F1 complex assembly factor 2 | |
| M. musculus | UniProtKB:Q91YY4 · MGI:MGI:2180561 (ATP12p · ATP12 · Atpaf2) | ATP synthase mitochondrial F1 complex assembly factor 2 | |
| R. norvegicus | NCBI:XP_220522 · RGD:1305161 (Atpaf2) | ATP synthase mitochondrial F1 complex assembly factor 2 | |
| S. cerevisiae | UniProtKB:P22135 · SGD:S000003716 (YJL180C · ATP12) | Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase | |
| S. pombe | UniProtKB:Q9UT16 · GeneDB_Spombe:SPAC9.12c (SPAC9.12c · atp12) | F1-ATPase chaperone Atp12 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P22135 · SGD:S000003716 |  19933271 Meulemans A, et al. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. J Biol Chem. 2010 Feb 5;285(6):4099-109. | The H. sapiens protein ATPAF2 complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| UniProtKB:P22135 · SGD:S000003716 | #604273 ENCEPHALOCARDIOMYOPATHY, MITOCHONDRIAL, NEONATAL, DUE TO ATP SYNTHASEDEFICIENCY;;ATPase DEFICIENCY |
| SGD Disease Papers (2) | |
| UniProtKB:P22135 · SGD:S000003716 | 14757859 De Meirleir L, et al. (2004) Respiratory chain complex V deficiency due to a mutation in the assembly gene ATP12. J Med Genet 41(2):120-4 |
| 12206899 Ackerman SH (2002) Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria. Biochim Biophys Acta 1555(1-3):101-5 | |