P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL3066

This family has 11 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae.

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GO3/OrthoMCL3066
11 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_563834.1 · TAIR:locus:2036079 (F7G19_11 · ATSNF4 · SNF4 · F7G19.11 · AT1G09020)PUTATIVE ACTIVATOR SUBUNIT OF SNF1-RELATED PROTEIN KINASE SNF4 · HOMOLOG OF YEAST SUCROSE NONFERMENTING 4⌘
C. elegansWB:WBGene00013732 · UniProtKB:Q9BHL6
D. rerioENSEMBL:ENSDARP00000007791
D. rerioUniProtKB:Q08CA6 · ZFIN:ZDB-GENE-060929-160 (zgc:153329)⌘
D. discoideumNCBI:EAL71195.1 · dictyBase:DDB_G0272542 (prkag)AMP-activated protein kinase gamma subunit, AMPK complex gamma subunit, CBS (cystathionine-beta-synthase) domain-containing protein⌘
D. melanogasterUniProtKB:Q9VDD2 · FB:FBgn0025803 (CG5806 · loe · CG17299 · SNF4Ag · anon-WO0118547.338 · EP3015b · SNF4A · Snfg · anon-WO0118547.575 · SNF4Agamma · SNF4a · Snfgamma · SNF4 · lochrig · loechrig · Lochrig · anon-WO0257455.21 · FBgn0025803)SNF4/AMP-activated protein kinase gamma subunit · SNF4/AMP-activated protein kinase gamma⌘
G. gallusUniProtKB:Q5ZK07 · ENTREZ:420435
H. sapiensENSEMBL:ENSG00000106617 · UniProtKB:Q9UGJ0 (AAKG2_HUMAN · IPI00646448 · IPI00219377 · IPI00005367 · PRKAG2 · Q9UGJ0)5'-AMP-activated protein kinase subunit gamma-2⌘
M. musculusUniProtKB:Q91WG5 · MGI:MGI:1336153 (Prkag2)protein kinase, AMP-activated, gamma 2 non-catalytic subunit⌘
R. norvegicusUniProtKB:Q4QRB9 · RGD:727782 (Prkag2)protein kinase, AMP-activated, gamma 2 non-catalytic subunit⌘
S. cerevisiaeUniProtKB:P12904 · SGD:S000003083 (SNF4 · CAT3 · SCI1 · YGL115W)Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member)⌘
ProteinPublicationCurator Notes
UniProtKB:P12904 · SGD:S000003083PMID:10929106 Kleinow T, et al. Functional identification of an Arabidopsis snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast. Plant J. 2000 Jul;23(1):115-22.The A. thaliana protein AT1G09020.1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12904 · SGD:S000003083PMID:11252725 Lumbreras V, et al. Domain fusion between SNF1-related kinase subunits during plant evolution. EMBO Rep. 2001 Jan;2(1):55-60.The A. thaliana protein AT1G09020.1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12904 · SGD:S000003083PMID:15890650 Corvey C, et al. Carbon Source-dependent assembly of the Snf1p kinase complex in Candida albicans. J Biol Chem. 2005 Jul 8;280(27):25323-30.The C. albicans protein CaSnf4 complements a homologous mutation in S. cerevisiae.
UniProtKB:P12904 · SGD:S000003083PMID:12008897 Slocombe SP, et al. Identification of SnIP1, a novel protein that interacts with SNF1-related protein kinase (SnRK1). Plant Mol Biol. 2002 May;49(1):31-44.The O. vulgare protein HSnIP1 does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P12904 · SGD:S000003083PMID:14636999 Lovas A, et al. Functional diversity of potato SNF1-related kinases tested in Saccharomyces cerevisiae. Gene. 2003 Dec 4;321:123-9.The S. tuberosum protein PKIN1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that S. tuberosum PKIN1 does not suppress a yeast snf4 null mutant.
UniProtKB:P12904 · SGD:S000003083PMID:14636999 Lovas A, et al. Functional diversity of potato SNF1-related kinases tested in Saccharomyces cerevisiae. Gene. 2003 Dec 4;321:123-9.The S. tuberosum protein StubSNF1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows that S. tuberosum StubSNF1 suppresses a yeast snf4 null mutant.
UniProtKB:P12904 · SGD:S000003083PMID:11252725 Lumbreras V, et al. Domain fusion between SNF1-related kinase subunits during plant evolution. EMBO Rep. 2001 Jan;2(1):55-60.The Z. mays protein ZmAKINbeta complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000106617 · UniProtKB:Q9UGJ0#194200 WOLFF-PARKINSON-WHITE SYNDROME;;WPW SYNDROMEPREEXCITATION SYNDROME, INCLUDED;;ACCESSORY ATRIOVENTRICULAR PATHWAYS, INCLUDED
UniProtKB:P12904 · SGD:S000003083#600858 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, WITH WOLFF-PARKINSON-WHITESYNDROME;;CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6; CMH6
#261740 GLYCOGEN STORAGE DISEASE OF HEART, LETHAL CONGENITAL;;PHOSPHORYLASE KINASE DEFICIENCY OF HEART;;GLYCOGEN STORAGE DISEASE OF HEART
SGD Disease Papers (2)
UniProtKB:P12904 · SGD:S000003083PMID:12397075 Daniel T and Carling D (2002) Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome. J Biol Chem 277(52):51017-24
PMID:11827995 Arad M, et al. (2002) Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest 109(3):357-62
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