P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL3021

This family has 11 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL3021
11 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_198386.1 · TAIR:locus:2182658 (T26D22_8 · T26D22.8 · AT5G35360 · CAC2)ACETYL-COA CARBOXYLASE⌘
C. elegansWB:WBGene00004258 (D2023.2 · pyc-1) · UniProtKB:O17732⌘
D. rerioUniProtKB:B3DGZ9 · ZFIN:ZDB-GENE-000831-1 (pc)pyruvate carboxylase⌘
D. melanogasterUniProtKB:Q0E9E2 · FB:FBgn0027580 (BcDNA · BcDNA:GH06348 · CG1516 · GH06348 · PC)pyruvate carboxylase⌘
G. gallusENTREZ:374263 · UniProtKB:Q8JHF6 (PYC · Q8JHF6 · IPI00580024)⌘
H. sapiensENSEMBL:ENSG00000173599 · UniProtKB:P11498 (P11498 · PYC_HUMAN · IPI00299402 · PC)Pyruvate carboxylase, mitochondrial⌘
M. musculusUniProtKB:Q05920 · MGI:MGI:97520 (Pcx · Pc)pyruvate carboxylase⌘
R. norvegicusUniProtKB:P52873 · RGD:3262 (Pc)pyruvate carboxylase⌘
S. cerevisiaeUniProtKB:P11154 · SGD:S000003030 (YGL062W · PYC1)Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate⌘
S. cerevisiaeUniProtKB:P32327 · SGD:S000000422 (YBR218C · PYC2)Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate⌘
S. pombeUniProtKB:Q9UUE1 · GeneDB_Spombe:SPBC17G9.11c (pyr1 · SPBC17G9.11c)pyruvate carboxylase⌘
ProteinPublicationCurator Notes
UniProtKB:P32327 · SGD:S000000422PMID:10481094 Bauer J, et al. By-product formation during exposure of respiring Saccharomyces cerevisiae cultures to excess glucose is not caused by a limited capacity of pyruvate carboxylase. FEMS Microbiol Lett. 1999 Oct 1;179(1):107-13.The E. coli protein Phosphoenolpyruvate carboxylase complements a homologous mutation in S. cerevisiae.
UniProtKB:P11154 · SGD:S000003030PMID:10481094 Bauer J, et al. By-product formation during exposure of respiring Saccharomyces cerevisiae cultures to excess glucose is not caused by a limited capacity of pyruvate carboxylase. FEMS Microbiol Lett. 1999 Oct 1;179(1):107-13.The E. coli protein Phosphoenolpyruvate carboxylase complements a homologous mutation in S. cerevisiae.
UniProtKB:P32327 · SGD:S000000422PMID:15701798 Flores CL, et al. Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Eukaryot Cell. 2005 Feb;4(2):356-64.The Y. lipolytica protein PYC1 complements a homologous mutation in S. cerevisiae. The Y. lipolytica PYC1 gene complemented the growth defect of a Saccharomyces cerevisiae pyc1 pyc2 mutant.
UniProtKB:P11154 · SGD:S000003030PMID:15701798 Flores CL, et al. Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Eukaryot Cell. 2005 Feb;4(2):356-64.The Y. lipolytica protein PYC1 complements a homologous mutation in S. cerevisiae. The Y. lipolytica PYC1 gene complemented the growth defect of a Saccharomyces cerevisiae pyc1 pyc2 mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P11154 · SGD:S000003030#266150 PYRUVATE CARBOXYLASE DEFICIENCY;;PC DEFICIENCY;;ATAXIA WITH LACTIC ACIDOSIS II;;LEIGH NECROTIZING ENCEPHALOPATHY DUE TO PYRUVATE CARBOXYLASE DEFICIENCY;;LEIGH SYNDROME DUE TO PYRUVATE CARBOXYLASE DEFICIENCY
SGD Disease Papers (1)
UniProtKB:P11154 · SGD:S000003030PMID:9300813 Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195(1):1-10
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