P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL2966

This family has 11 members: 1 Caenorhabditis elegans, 1 Danio rerio, 1 Drosophila melanogaster, 1 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/OrthoMCL2966
11 members.
OrganismProtein (Synonyms)DescriptionAmiGO
C. elegansWB:WBGene00004061 (pmp-4 · T02D1.5) · UniProtKB:O45730⌘
D. rerioENSEMBL:ENSDARP00000076957
D. melanogasterFB:FBgn0039890 (CG2316) · UniProtKB:Q7JUN3⌘
G. gallusNCBI:XP_415938 · ENTREZ:417694
H. sapiensENSEMBL:ENSG00000101986 · UniProtKB:P33897 (ABCD1_HUMAN · IPI00291373 · ABCD1 · ALD · P33897)ATP-binding cassette sub-family D member 1⌘
H. sapiensENSEMBL:ENSG00000173208 · UniProtKB:Q9UBJ2 (ALD1 · ALDRP · ALDR · Q9UBJ2 · ABCD2_HUMAN · ABCD2 · IPI00002618 · ALDL1)ATP-binding cassette sub-family D member 2⌘
M. musculusUniProtKB:P48410 · MGI:MGI:1349215 (ALDP · Aldgh · Ald · Abcd1)ATP-binding cassette, sub-family D (ALD), member 1⌘
M. musculusUniProtKB:Q61285 · MGI:MGI:1349467 (ABC39 · ALDR · ALDL1 · Abcd2)adrenoleukodystrophy related · ATP-binding cassette, sub-family D (ALD), member 2⌘
R. norvegicusNCBI:XP_001059399 · RGD:1562128 (Abcd1)ATP-binding cassette, sub-family D (ALD), member 1⌘
R. norvegicusUniProtKB:Q9QY44 · RGD:69244 (Abcd2)ATP-binding cassette, sub-family D (ALD), member 2⌘
S. cerevisiaeUniProtKB:P41909 · SGD:S000006068 (PAT2 · PXA1 · PAL1 · SSH2 · YPL147W · LPI1)Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000101986 · UniProtKB:P33897#300100 ADRENOLEUKODYSTROPHY; ALD;;ADDISON DISEASE AND CEREBRAL SCLEROSIS;;ADRENOMYELONEUROPATHY; AMN;;SIEMERLING-CREUTZFELDT DISEASE;;BRONZE SCHILDER DISEASE;;MELANODERMIC LEUKODYSTROPHY
UniProtKB:P41909 · SGD:S000006068#300475 CONTIGUOUS ABCD1/DXS1375E DELETION SYNDROME;;CADDS
SGD Disease Papers (6)
UniProtKB:P41909 · SGD:S000006068PMID:9395310 Verleur N, et al. (1997) Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system. Eur J Biochem 249(3):657-61
PMID:8993619 Shani N, et al. (1996) An S. cerevisiae peroxisomal transporter, orthologous to the human adrenoleukodystrophy protein, appears to be a heterodimer of two half ABC transporters: Pxa1p and Pxa2p. Ann N Y Acad Sci 804:770-2
PMID:8876235 Shani N and Valle D (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A 93(21):11901-6
PMID:8647887 Swartzman EE, et al. (1996) The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J Cell Biol 132(4):549-63
PMID:8621506 Shani N, et al. (1996) Characterization and analysis of conserved motifs in a peroxisomal ATP-binding cassette transporter. J Biol Chem 271(15):8725-30
PMID:7597071 Shani N, et al. (1995) PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene. Proc Natl Acad Sci U S A 92(13):6012-6
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