This family has 11 members: 2 Arabidopsis thaliana, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | TAIR:locus:2182192 (T24G5.100 · AT5G19200 · T24G5_100) · NCBI:NP_197421.1 |  | |
| A. thaliana | NCBI:NP_187257.2 · TAIR:locus:2080379 (AT3G06060 · F24F17.4 · F24F17_4) | | |
| D. rerio | UniProtKB:Q803B4 · ZFIN:ZDB-GENE-040426-853 (kdsr) | 3-ketodihydrosphingosine reductase | |
| D. discoideum | UniProtKB:Q556J2 · dictyBase:DDB_G0272883 (ksrA · ksrA-1) | short-chain dehydrogenase/reductase (SDR) family protein, 3-dehydrosphinganine reductase, 3-ketosphinganine reductase | |
| D. melanogaster | FB:FBgn0039304 (CG10425) · UniProtKB:Q9VBU5 | | |
| G. gallus | UniProtKB:Q5ZKZ6 (Q5ZKZ6 · RCJMB04_8j12 · IPI00585481) · ENTREZ:420902 | | |
| H. sapiens | ENSEMBL:ENSG00000119537 · UniProtKB:Q06136 (IPI00029015 · FVT1 · Q06136 · KDSR · KDSR_HUMAN) | 3-ketodihydrosphingosine reductase | |
| M. musculus | UniProtKB:Q6GV12 · MGI:MGI:1918000 (Kdsr · Fvt1) | 3-ketodihydrosphingosine reductase | |
| R. norvegicus | NCBI:NP_001101812 · RGD:1307775 (Kdsr) | 3-ketodihydrosphingosine reductase | |
| S. cerevisiae | UniProtKB:P38342 · SGD:S000000469 (TSC10 · YBR265W) | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family | |
| S. pombe | GeneDB_Spombe:SPCC1450.15 (SPCC1450.15 · pig-F) · UniProtKB:Q9Y7P2 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P38342 · SGD:S000000469 |  15969533 Yi H, et al. Direct evidence for the function of FUM13 in 3-ketoreduction of mycotoxin fumonisins in Fusarium verticillioides. J Agric Food Chem. 2005 Jun 29;53(13):5456-60. | The F. verticillioides protein FUM13 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P38342 · SGD:S000000469 | 15328338 Kihara A, et al. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. J Biol Chem. 2004 Nov 19;279(47):49243-50. | The H. sapiens protein Q06136 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:P38342 · SGD:S000000469 | 15328338 Kihara A, et al. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. J Biol Chem. 2004 Nov 19;279(47):49243-50. | The M. musculus protein Q6GV12 complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (1) | |
|---|---|
| UniProtKB:P38342 · SGD:S000000469 | 17420465 Krebs S, et al. (2007) A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy. Proc Natl Acad Sci U S A 104(16):6746-51 |