P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL260

This family has 32 members: 6 Arabidopsis thaliana, 1 Caenorhabditis elegans, 3 Danio rerio, 3 Drosophila melanogaster, 3 Gallus gallus, 4 Homo sapiens, 4 Mus musculus, 3 Rattus norvegicus, 4 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL260
32 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_175220.2 · TAIR:locus:2202410 (HXK3 · T2E6.5 · AT1G47840 · T2E6_5)HEXOKINASE 3⌘
A. thalianaNCBI:NP_195497.1 · TAIR:locus:2137564 (HKL3 · AT4G37840 · T28I19_120 · T28I19.120)HEXOKINASE-LIKE 3⌘
A. thalianaNCBI:NP_188639.2 · TAIR:locus:2087590 (ATHXK4 · AT3G20040 · MAL21.4 · HKL2)HEXOKINASE-LIKE 2⌘
A. thalianaNCBI:NP_179576.1 · TAIR:locus:2051920 (F6F22_11 · F6F22.11 · AT2G19860 · HXK2 · ATHXK2)ARABIDOPSIS THALIANA HEXOKINASE 2 · HEXOKINASE 2⌘
A. thalianaNCBI:NP_175463.1 · TAIR:locus:2008031 (HKL1 · AT1G50460 · F11F12_18 · F11F12.18)HEXOKINASE-LIKE 1⌘
A. thalianaNCBI:NP_194642.1 · TAIR:locus:2119931 (ATHXK1 · HXK1 · GIN2 · F19B15_160 · AT4G29130 · HEXOKINASE · F19B15.160)GLUCOSE INSENSITIVE 2 · HEXOKINASE 1 · ARABIDOPSIS THALIANA HEXOKINASE 1⌘
C. elegansWB:WBGene00008780 (F14B4.2) · UniProtKB:Q19440 (F14B4.2 · F14B4.2a)Protein F14B4.2a, confirmed by transcript evidence⌘⌘
D. rerioUniProtKB:Q6DEJ8 · ZFIN:ZDB-GENE-030131-9801 (hkdc1)hexokinase domain containing 1⌘
D. rerioUniProtKB:Q7ZUM3 · ZFIN:ZDB-GENE-040426-2848 (hk1)hexokinase 1⌘
D. rerioUniProtKB:Q7ZVL7 · ZFIN:ZDB-GENE-040426-2017 (hk2)hexokinase 2⌘
D. melanogasterFB:FBgn0042710 (Hexokinase · Hex-t2 · HK · anon-WO0140519.203 · hexokinase · CG5443 · CG32849 · Hex) · UniProtKB:Q9NFT7⌘
D. melanogasterUniProtKB:Q9GNE4 · FB:FBgn0001187 (Hexokinase · HEX · HEX-C · CG8094 · HK · Hk · hexokinase · DM2 · Hex-3 · Hex-C · Hexokinase-3 · HEX-3 · Hex-c · Hex · Fk · Fructokinase · CT22069)Hexokinase C⌘
D. melanogasterUniProtKB:Q9W330 · FB:FBgn0001186 (Hexokinase · HEX · HK · Hex-A · Hex-A,B · hexokinase · Hex-A:B · DM1 · CG3001 · Hex)hexokinase A · Hexokinase A⌘
G. gallusNCBI:XP_421579 · ENTREZ:423698
G. gallusUniProtKB:Q8AYP7 (HK2 · IPI00582456 · Q8AYP7) · ENTREZ:374044⌘
G. gallusUniProtKB:Q8AYP8 (IPI00603534 · Q8AYP8 · HK1) · ENTREZ:373889⌘
H. sapiensENSEMBL:ENSG00000156510 · UniProtKB:Q2TB90 (HKDC1 · Q2TB90 · IPI00856069 · IPI00414612 · IPI00855827 · HKDC1_HUMAN)Putative hexokinase HKDC1⌘
H. sapiensENSEMBL:ENSG00000156515 · UniProtKB:P19367 (IPI00018246 · P19367 · Hexokinase-1 · IPI00220667 · HXK1_HUMAN · HK1 · IPI00220665 · IPI00220663)⌘
H. sapiensENSEMBL:ENSG00000159399 · UniProtKB:P52789 (P52789 · IPI00102864 · HK2 · Hexokinase-2 · HXK2_HUMAN)⌘
H. sapiensENSEMBL:ENSG00000160883 · UniProtKB:P52790 (HK3 · IPI00005118 · P52790 · Hexokinase-3 · HXK3_HUMAN)⌘
M. musculusUniProtKB:Q91W97 · MGI:MGI:2384910 (Hkdc1)hexokinase domain containing 1⌘
M. musculusUniProtKB:P17710 · MGI:MGI:96103 (Hk1-s · Hk1 · mHk1-s · Hk-1)hexokinase 1⌘
M. musculusUniProtKB:O08528 · MGI:MGI:1315197 (HKII · Hk2)hexokinase 2⌘
M. musculusUniProtKB:Q3TRM8 · MGI:MGI:2670962 (Hk3)hexokinase 3⌘
R. norvegicusUniProtKB:P05708 · RGD:2796 (Hk1)hexokinase 1⌘
R. norvegicusUniProtKB:P27881 · RGD:2797 (Hk2)hexokinase 2⌘
R. norvegicusUniProtKB:P27926 · RGD:2798 (Hk3)hexokinase 3 (white cell)⌘
S. cerevisiaeUniProtKB:Q04409 · SGD:S000002924 (YDR516C · EMI2)Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1⌘
S. cerevisiaeUniProtKB:P04806 · SGD:S000001949 (HXK1 · YFR053C)Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism⌘
S. cerevisiaeUniProtKB:P04807 · SGD:S000003222 (HKB · YGL253W · SCI2 · HEX1 · HXK2)Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol⌘
S. cerevisiaeUniProtKB:P17709 · SGD:S000000545 (GLK1 · HOR3 · YCL040W)Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism⌘
S. pombeUniProtKB:Q09756 · GeneDB_Spombe:SPAC24H6.04 (SPAC24H6.04 · hxk1)hexokinase 1⌘
ProteinPublicationCurator Notes
UniProtKB:P17709 · SGD:S000000545PMID:9112782 Kanayama Y, et al. Divergent fructokinase genes are differentially expressed in tomato. Plant Physiol. 1997 Apr;113(4):1379-84.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:9112782 Kanayama Y, et al. Divergent fructokinase genes are differentially expressed in tomato. Plant Physiol. 1997 Apr;113(4):1379-84.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:9112782 Kanayama Y, et al. Divergent fructokinase genes are differentially expressed in tomato. Plant Physiol. 1997 Apr;113(4):1379-84.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk1 complements a homologous mutation in S. cerevisiae. Tomato Frk1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:17324236 Gharbi I, et al. Effect of hexokinase activity on tomato root metabolism during prolonged hypoxia. Plant Cell Environ. 2007 Apr;30(4):508-17.The S. cerevisiae protein NONE was expressed in S. lycopersicum, but complementation was not directly tested. Yeast HXK2 and Arabidopsis HXK1 were overexpressed in tomato.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK1 complements a homologous mutation in S. cerevisiae. Rice HXK1 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK1 complements a homologous mutation in S. cerevisiae. Rice HXK1 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK1 complements a homologous mutation in S. cerevisiae. Rice HXK1 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:10482667 Veramendi J, et al. Antisense repression of hexokinase 1 leads to an overaccumulation of starch in leaves of transgenic potato plants but not to significant changes in tuber carbohydrate metabolism. Plant Physiol. 1999 Sep;121(1):123-34.The S. tuberosum protein StHK1 complements a homologous mutation in S. cerevisiae. Potato hexokinase 1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:10482667 Veramendi J, et al. Antisense repression of hexokinase 1 leads to an overaccumulation of starch in leaves of transgenic potato plants but not to significant changes in tuber carbohydrate metabolism. Plant Physiol. 1999 Sep;121(1):123-34.The S. tuberosum protein StHK1 complements a homologous mutation in S. cerevisiae. Potato hexokinase 1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:14507429 Bonini BM, et al. Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta. 2003 Sep 30;1606(1-3):83-93.The S. pombe protein Hxk2 complements a homologous mutation in S. cerevisiae. S. pombe Hxk2 rescues an S. cerevisiae hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:14507429 Bonini BM, et al. Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta. 2003 Sep 30;1606(1-3):83-93.The S. pombe protein Hxk2 complements a homologous mutation in S. cerevisiae. S. pombe Hxk2 rescues an S. cerevisiae hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:14507429 Bonini BM, et al. Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Biochim Biophys Acta. 2003 Sep 30;1606(1-3):83-93.The S. pombe protein Hxk2 complements a homologous mutation in S. cerevisiae. S. pombe Hxk2 rescues an S. cerevisiae hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:10482667 Veramendi J, et al. Antisense repression of hexokinase 1 leads to an overaccumulation of starch in leaves of transgenic potato plants but not to significant changes in tuber carbohydrate metabolism. Plant Physiol. 1999 Sep;121(1):123-34.The S. tuberosum protein StHK1 complements a homologous mutation in S. cerevisiae. Potato hexokinase 1 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk2 complements a homologous mutation in S. cerevisiae. Tomato Frk2 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk2 complements a homologous mutation in S. cerevisiae. Tomato Frk2 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:9576777 Kanayama Y, et al. Tomato fructokinases exhibit differential expression and substrate regulation. Plant Physiol. 1998 May;117(1):85-90.The L. esculentum protein Frk2 complements a homologous mutation in S. cerevisiae. Tomato Frk2 complements a yeast glk1 hxk1 hxk2 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK10 complements a homologous mutation in S. cerevisiae. Rice HXK10 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK10 complements a homologous mutation in S. cerevisiae. Rice HXK10 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK10 complements a homologous mutation in S. cerevisiae. Rice HXK10 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK2 complements a homologous mutation in S. cerevisiae. Rice HXK2 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK2 complements a homologous mutation in S. cerevisiae. Rice HXK2 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK2 complements a homologous mutation in S. cerevisiae. Rice HXK2 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK3 complements a homologous mutation in S. cerevisiae. Rice HXK3 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK3 complements a homologous mutation in S. cerevisiae. Rice HXK3 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK3 complements a homologous mutation in S. cerevisiae. Rice HXK3 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK4 complements a homologous mutation in S. cerevisiae. Rice HXK4 lacking a putative chloroplast-targeting sequence complements a yeast hxk1 hxk2 glk1 triple mutant, but full-length HXK4 does not.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK4 complements a homologous mutation in S. cerevisiae. Rice HXK4 lacking a putative chloroplast-targeting sequence complements a yeast hxk1 hxk2 glk1 triple mutant, but full-length HXK4 does not.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK4 complements a homologous mutation in S. cerevisiae. Rice HXK4 lacking a putative chloroplast-targeting sequence complements a yeast hxk1 hxk2 glk1 triple mutant, but full-length HXK4 does not.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK5 complements a homologous mutation in S. cerevisiae. Rice HXK5 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK5 complements a homologous mutation in S. cerevisiae. Rice HXK5 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK5 complements a homologous mutation in S. cerevisiae. Rice HXK5 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK6 complements a homologous mutation in S. cerevisiae. Rice HXK6 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK6 complements a homologous mutation in S. cerevisiae. Rice HXK6 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK6 complements a homologous mutation in S. cerevisiae. Rice HXK6 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK7 complements a homologous mutation in S. cerevisiae. Rice HXK7 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK7 complements a homologous mutation in S. cerevisiae. Rice HXK7 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK7 complements a homologous mutation in S. cerevisiae. Rice HXK7 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK8 complements a homologous mutation in S. cerevisiae. Rice HXK8 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK8 complements a homologous mutation in S. cerevisiae. Rice HXK8 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK8 complements a homologous mutation in S. cerevisiae. Rice HXK8 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK9 complements a homologous mutation in S. cerevisiae. Rice HXK9 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK9 complements a homologous mutation in S. cerevisiae. Rice HXK9 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:16552590 Cho JI, et al. Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.). Planta. 2006 Aug;224(3):598-611.The O. sativa protein OsHXK9 complements a homologous mutation in S. cerevisiae. Rice HXK9 complements a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:11164592 Menu T, et al. Cloning and characterization of a cDNA encoding hexokinase from tomato. Plant Sci. 2001 Jan 5;160(2):209-218.The L. esculentum protein LeHXK2 complements a homologous mutation in S. cerevisiae. This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose.
UniProtKB:P04806 · SGD:S000001949PMID:11164592 Menu T, et al. Cloning and characterization of a cDNA encoding hexokinase from tomato. Plant Sci. 2001 Jan 5;160(2):209-218.The L. esculentum protein LeHXK2 complements a homologous mutation in S. cerevisiae. This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose.
UniProtKB:P17709 · SGD:S000000545PMID:11164592 Menu T, et al. Cloning and characterization of a cDNA encoding hexokinase from tomato. Plant Sci. 2001 Jan 5;160(2):209-218.The L. esculentum protein LeHXK2 complements a homologous mutation in S. cerevisiae. This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose.
UniProtKB:P04806 · SGD:S000001949PMID:11571755 Mayordomo I, et al. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast. 2001 Oct;18(14):1309-16.The H. sapiens protein P35557 complements a homologous mutation in S. cerevisiae. This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P17709 · SGD:S000000545PMID:11571755 Mayordomo I, et al. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast. 2001 Oct;18(14):1309-16.The H. sapiens protein P35557 complements a homologous mutation in S. cerevisiae. This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04807 · SGD:S000003222PMID:11571755 Mayordomo I, et al. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast. 2001 Oct;18(14):1309-16.The H. sapiens protein P35557 complements a homologous mutation in S. cerevisiae. This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant.
UniProtKB:P04806 · SGD:S000001949PMID:8321195 Prior C, et al. The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAG1 in Kluyveromyces lactis. Mol Cell Biol. 1993 Jul;13(7):3882-9.The K. lactis protein RAG5 does not complement a homologous mutation in S. cerevisiae. K. lactis RAG5 does not restore glucose repression in a yeast hxk1 hxk2 double mutant.
UniProtKB:P04807 · SGD:S000003222PMID:8321195 Prior C, et al. The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAG1 in Kluyveromyces lactis. Mol Cell Biol. 1993 Jul;13(7):3882-9.The K. lactis protein RAG5 does not complement a homologous mutation in S. cerevisiae. K. lactis RAG5 does not restore glucose repression in a yeast hxk1 hxk2 double mutant.
UniProtKB:P04806 · SGD:S000001949PMID:11571755 Mayordomo I, et al. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast. 2001 Oct;18(14):1309-16.The H. sapiens protein GCK does not complement a homologous mutation in S. cerevisiae.
UniProtKB:P04807 · SGD:S000003222PMID:11571755 Mayordomo I, et al. Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast. 2001 Oct;18(14):1309-16.The H. sapiens protein GCK complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P04806 · SGD:S000001949#235700 HEXOKINASE DEFICIENCY HEMOLYTIC ANEMIA
SGD Disease Papers (1)
UniProtKB:P04806 · SGD:S000001949PMID:17051422 Miller S, et al. (2007) Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism. Amino Acids 32(4):593-602
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