P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL24755

This family has 2 members: 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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2 members.
OrganismProtein (Synonyms)DescriptionAmiGO
S. cerevisiaeUniProtKB:P06842 · SGD:S000001868 (STE2 · YFL026W)Receptor for alpha-factor pheromone⌘
S. pombeUniProtKB:Q00619 · GeneDB_Spombe:SPAC11H11.04 (mam2 · SPAC11H11.04)pheromone p-factor receptor⌘
ProteinPublicationCurator Notes
UniProtKB:P06842 · SGD:S000001868PMID:15749052 Janiak AM, et al. Functional expression of the Candida albicans alpha-factor receptor in Saccharomyces cerevisiae. Fungal Genet Biol. 2005 Apr;42(4):328-38.The C. albicans protein CaSTE2 complements a homologous mutation in S. cerevisiae. This paper describes the biochemical study of the C. albicans alpha-factor receptor (CaSte2p) in S. cerevisiae.
UniProtKB:P06842 · SGD:S000001868PMID:15721304 Yin D, et al. Successful expression of a functional yeast G-protein-coupled receptor (Ste2) in mammalian cells. Biochem Biophys Res Commun. 2005 Apr 1;329(1):281-7.The S. cerevisiae protein STE2 was expressed in H. sapiens, but complementation was not directly tested. This paper shows the successful expression of a functional yeast G-protein-coupled receptor (Ste2) in human HEK293 cells.
Sequences in this family.fasta
SGD Disease Papers (2)
UniProtKB:P06842 · SGD:S000001868PMID:10548735 Josefsson LG (1999) Evidence for kinship between diverse G-protein coupled receptors. Gene 239(2):333-40
UniProtKB:P06842 · SGD:S000001868PMID:11853883 Kong JL, et al. (2002) Inhibition of somatostatin receptor 5-signaling by mammalian regulators of G-protein signaling (RGS) in yeast. Biochim Biophys Acta 1542(1-3):95-105
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