P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL24714

This family has 2 members: 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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2 members.
OrganismProtein (Synonyms)DescriptionAmiGO
S. cerevisiaeUniProtKB:P41695 · SGD:S000003420 (BUB1 · YGR188C)Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p⌘
S. pombeUniProtKB:O94751 · GeneDB_Spombe:SPCC1322.12c (SPCC1322.12c · bub1)serine/threonine protein kinase Bub1⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
SGD Disease Papers (10)
UniProtKB:P41695 · SGD:S000003420PMID:10395177 Yamaguchi K, et al. (1999) Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett 139(2):183-7
UniProtKB:P41695 · SGD:S000003420PMID:9521327 Cahill DP, et al. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392(6673):300-3
PMID:17360454 Yuen KW, et al. (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104(10):3925-30
PMID:12096343 Ru HY, et al. (2002) hBUB1 defects in leukemia and lymphoma cells. Oncogene 21(30):4673-9
PMID:11932908 Saeki A, et al. (2002) Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma. Cancer 94(7):2047-54
PMID:11905802 Jallepalli PV and Lengauer C (2001) Chromosome segregation and cancer: cutting through the mystery. Nat Rev Cancer 1(2):109-17
PMID:11400114 Hernando E, et al. (2001) Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int J Cancer 95(4):223-7
PMID:11355300 Reis RM, et al. (2001) Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas. Acta Neuropathol 101(4):297-304
PMID:11283619 Kaplan KB, et al. (2001) A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3(4):429-32
PMID:11146226 Haruki N, et al. (2001) Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett 162(2):201-5
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