This family has 13 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_179770.1 · TAIR:locus:2052469 (ATRNR1 · CLS8 · RNR1 · R1 · F7D8_11 · F7D8.11 · AT2G21790) | RIBONUCLEOTIDE REDUCTASE LARGE SUBUNIT 1 · RIBONUCLEOTIDE REDUCTASE 1 · CRINKLY LEAVES 8 |  |
| C. elegans | WB:WBGene00004391 (T23G5.1 · rnr-1) · UniProtKB:Q03604 (T23G5.1 · RIR1_CAEEL · rnr-1) | Ribonucleoside-diphosphate reductase large subunit | |
| D. rerio | UniProtKB:P79732 · ZFIN:ZDB-GENE-990415-247 (rrm1) | ribonucleotide reductase M1 polypeptide | |
| D. discoideum | UniProtKB:Q54Q71 · dictyBase:DDB_G0284071 (rnrA · RNR) | ribonucleoside-diphosphate reductase, ribonucleotide reductase large subunit | |
| D. melanogaster | UniProtKB:P48591 · FB:FBgn0011703 (RNR1 · RntL · CG5371 · RnrM1 · l(2)k06709 · RnrL · DmRNR1) | Ribonucleoside diphosphate reductase M1 subunit · Ribonucleoside diphosphate reductase large subunit · ribonucleoside-diphosphate reductase large subunit | |
| E. coli | UniProtKB:P00452 · ECOLI:NRDA-MONOMER (b2234 · DnaF · NrdA · nrdA · B2234 · dnaF · ECK2226) | ribonucleoside diphosphate reductase 1 · alpha subunit | |
| G. gallus | ENTREZ:419081 · UniProtKB:Q5ZM69 (Q5ZM69 · IPI00580561 · RCJMB04_2p9) | Ribonucleoside-diphosphate reductase | |
| H. sapiens | ENSEMBL:ENSG00000167325 · UniProtKB:P23921 (IPI00013871 · P23921 · RR1 · RRM1 · RIR1_HUMAN) | Ribonucleoside-diphosphate reductase large subunit | |
| M. musculus | UniProtKB:P07742 · MGI:MGI:98180 (Rrm1 · RnrM1) | ribonucleotide reductase M1 | |
| R. norvegicus | UniProtKB:Q5U2Q5 · RGD:1598288 (Rrm1-ps1) | ribonucleotide reductase M1, pseudogene 1 | |
| S. cerevisiae | UniProtKB:P21524 · SGD:S000000872 (SDS12 · RNR1 · YER070W · CRT7 · RIR1) | One of two large regulatory subunits of ribonucleotide-diphosphate reductase | |
| S. cerevisiae | UniProtKB:P21672 · SGD:S000001328 (RNR3 · DIN1 · RIR3 · YIL066C) | One of two large regulatory subunits of ribonucleotide-diphosphate reductase | |
| S. pombe | UniProtKB:P36602 · GeneDB_Spombe:SPAC1F7.05 (cdc22 · SPAC1F7.05) | ribonucleoside reductase large subunit Cdc22 | |
No functional conservation results.
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| SGD Disease Papers (1) | |
|---|---|
| UniProtKB:P21524 · SGD:S000000872 |  18588281 Cappellacci L, et al. (2008) Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N(6)-Substituted 3'-C-Methyladenosine Derivatives. J Med Chem 51(14):4260-4269 |