This family has 13 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_201145.1 · TAIR:locus:2167316 (ADK1 · MLE2_3 · MLE2.3 · AT5G63400) | ADENYLATE KINASE 1 |  |
| A. thaliana | NCBI:NP_199848.1 · TAIR:locus:2177527 (MXI22_8 · MXI22.8 · AT5G50370) | | |
| C. elegans | UniProtKB:P34346 · WB:WBGene00002879 (C29E4.8 · let-754) | | |
| D. rerio | UniProtKB:Q7T3D7 · ZFIN:ZDB-GENE-030131-512 (ak2) | adenylate kinase 2 | |
| D. discoideum | UniProtKB:Q54QJ9 · dictyBase:DDB_G0283805 (adkA · ADK) | adenylate kinase | |
| D. melanogaster | UniProtKB:Q9U915 · FB:FBgn0022708 (Adk2 · anon-Dak2 · BcDNA:SD09634 · Dak2 · CG3140 · ADK-2) | Adenylate kinase-2 | |
| E. coli | UniProtKB:P69441 · ECOLI:ADENYL-KIN-MONOMER (ECK0468 · Adk · plsA · b0474 · dnaW · adk) | adenylate kinase | |
| G. gallus | NCBI:XP_425786 · ENTREZ:428227 | ||
| H. sapiens | ENSEMBL:ENSG00000004455 · UniProtKB:P54819 (IPI00218989 · IPI00172460 · IPI00218988 · KAD2_HUMAN · IPI00215901 · P54819 · AK2 · ADK2) | Adenylate kinase 2, mitochondrial | |
| M. musculus | UniProtKB:Q9WTP6 · MGI:MGI:87978 (Ak2 · D4Ertd220e · Ak-2) | adenylate kinase 2 | |
| R. norvegicus | RGD:2077 (Ak2) · UniProtKB:P29410 (KAD2_RAT · IPI00230857 · Ak2 · IPI00923141 · P29410) | adenylate kinase 2 · Adenylate kinase 2, mitochondrial | |
| S. cerevisiae | UniProtKB:P07170 · SGD:S000002634 (ADK1 · AKY1 · AKY2 · YDR226W) | Adenylate kinase, required for purine metabolism | |
| S. pombe | UniProtKB:P33075 · GeneDB_Spombe:SPAC4G9.03 (SPAC4G9.03 · adk1) | adenylate kinase Adk1 | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P07170 · SGD:S000002634 |  8439550 Konrad M. Identification and characterization of a yeast gene encoding an adenylate kinase homolog. Biochim Biophys Acta. 1993 Feb 20;1172(1-2):12-6. | The S. cerevisiae protein ADK1 was expressed in E. coli, but complementation was not directly tested. | |
| UniProtKB:P07170 · SGD:S000002634 | 18433446 Gauthier S, et al. Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations. Mol Microbiol. 2008 Jun;68(6):1583-94. | The H. sapiens protein AK1 complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| ENSEMBL:ENSG00000004455 · UniProtKB:P54819 | %267500 RETICULAR DYSGENESIA;;RETICULAR DYSGENESIS;;CONGENITAL ALEUKIA;;SEVERE COMBINED IMMUNODEFICIENCY WITH LEUKOPENIA;;DE VAAL DISEASE;;HEMATOPOIETIC HYPOPLASIA, GENERALIZED |