P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL16339

This family has 3 members: 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL16339
3 members.
OrganismProtein (Synonyms)DescriptionAmiGO
S. cerevisiaeUniProtKB:P28496 · SGD:S000001491 (YKL008C · DGT1 · LAC1)Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p⌘
S. cerevisiaeUniProtKB:P38703 · SGD:S000000995 (YHL003C · LAG1)Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p⌘
S. pombeUniProtKB:O59735 · GeneDB_Spombe:SPBC3E7.15c (SPBC4F6.02c · SPBC3E7.15c · mug83 · lac1)sphingosine N-acyltransferase Lac1⌘
ProteinPublicationCurator Notes
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The C. elegans protein C09G4.1 complements a homologous mutation in S. cerevisiae. This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein P27539 complements a homologous mutation in S. cerevisiae. This paper shows that human LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The C. elegans protein C09G4.1 complements a homologous mutation in S. cerevisiae. This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein Q15629 does not complement a homologous mutation in S. cerevisiae. This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:9872981 Jiang JC, et al. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 1998 Dec;8(12):1259-72.The H. sapiens protein Q15629 does not complement a homologous mutation in S. cerevisiae. This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 complements a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 complements a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 does not complement a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q96G23 does not complement a homologous mutation in S. cerevisiae. This paper shows that a clone of LASS2 complements a yeast lag1 lac1 mutant, but a shorter clone lacking the HOX1 domain does not.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9HA82 complements a homologous mutation in S. cerevisiae. This paper shows that human LASS4 complements a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9HA82 complements a homologous mutation in S. cerevisiae. This paper shows that human LASS4 complements a yeast lag1 lac1 mutant.
UniProtKB:P38703 · SGD:S000000995PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9UBY8 does not complement a homologous mutation in S. cerevisiae. This paper shows that human CLN8 does not complement a yeast lag1 lac1 mutant.
UniProtKB:P28496 · SGD:S000001491PMID:12869556 Guillas I, et al. Human homologues of LAG1 reconstitute Acyl-CoA-dependent ceramide synthesis in yeast. J Biol Chem. 2003 Sep 26;278(39):37083-91.The H. sapiens protein Q9UBY8 does not complement a homologous mutation in S. cerevisiae. This paper shows that human CLN8 does not complement a yeast lag1 lac1 mutant.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (3)
UniProtKB:P38703 · SGD:S000000995PMID:19148536 Teufel A, et al. (2009) The longevity assurance homologue of yeast lag1 (Lass) gene family (Review). Int J Mol Med 23(2):135-40
UniProtKB:P38703 · SGD:S000000995PMID:19148536 Teufel A, et al. (2009) The longevity assurance homologue of yeast lag1 (Lass) gene family (Review). Int J Mol Med 23(2):135-40
PMID:15317812 Koybasi S, et al. (2004) Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem 279(43):44311-9
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