This family has 14 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 2 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Interactive Java Applets: Notung Tree Analysis · Jalview Alignment
| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_175284.2 · TAIR:locus:2198030 (T1N15_12 · AT1G48510 · T1N15.12) |  | |
| A. thaliana | NCBI:NP_566592.1 · TAIR:locus:2088510 (AT3G17910 · SURF1 · MEB5.13) | SURFEIT 1 | |
| C. elegans | WB:WBGene00004787 · UniProtKB:Q9N5N8 | ||
| D. rerio | UniProtKB:A5WUL6 · ZFIN:ZDB-GENE-041108-2 (surf1) | surfeit 1 | |
| D. discoideum | UniProtKB:Q556J9 · dictyBase:DDB_G0272889 | ||
| D. discoideum | UniProtKB:Q556J9 · dictyBase:DDB_G0274001 | ||
| D. melanogaster | UniProtKB:Q9U4F3 · FB:FBgn0029117 (CG9943 · BcDNA:GH23574 · Surf1) | Surfeit 1 · Surfeit locus protein 1 | |
| G. gallus | ENTREZ:417157 · UniProtKB:Q800L1 (Q800L1 · IPI00571267 · SURF1 · SURF1_CHICK · SURF-1) | Surfeit locus protein 1 | |
| H. sapiens | ENSEMBL:ENSG00000148290 · UniProtKB:Q15526 (IPI00018034 · IPI00642942 · Q15526 · SURF1_HUMAN · SURF1 · SURF-1) | Surfeit locus protein 1 | |
| M. musculus | UniProtKB:P09925 · MGI:MGI:98443 (Surf-1 · Surf1) | surfeit gene 1 | |
| R. norvegicus | UniProtKB:Q9QXU2 · RGD:620527 (Surf1) | surfeit 1 | |
| R. norvegicus | UniProtKB:Q9QXU2 · RGD:1561980 (Surf4) | surfeit 4 | |
| S. cerevisiae | UniProtKB:P53266 · SGD:S000003344 (YGR112W · SHY1) | Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV) | |
| S. pombe | UniProtKB:Q9Y810 · GeneDB_Spombe:SPBC1215.01 (shy1 · SPBC1215.01) | SURF-family protein Shy1 | |
No functional conservation results.
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (2) | |
|---|---|
| ENSEMBL:ENSG00000148290 · UniProtKB:Q15526 | #220110 MITOCHONDRIAL COMPLEX IV DEFICIENCY;;CYTOCHROME c OXIDASE DEFICIENCY;;COX DEFICIENCY |
| UniProtKB:P53266 · SGD:S000003344 | #256000 LEIGH SYNDROME; LS;;NECROTIZING ENCEPHALOPATHY, INFANTILE SUBACUTE, OF LEIGH; SNELEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX II DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX III DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX IV DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX V DEFICIENCY, INCLUDED |
| SGD Disease Papers (6) | |
| UniProtKB:P53266 · SGD:S000003344 |  18045776 Fontanesi F, et al. (2008) Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells. Hum Mol Genet 17(6):775-88 |
| 12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4 | |
| 11782424 Barrientos A, et al. (2002) Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome. EMBO J 21(1-2):43-52 | |
| 11579424 Shoubridge EA (2001) Cytochrome c oxidase deficiency. Am J Med Genet 106(1):46-52 | |
| 11389896 Nijtmans LG, et al. (2001) Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeast. FEBS Lett 498(1):46-51 | |
| 11044474 Robinson BH (2000) Human cytochrome oxidase deficiency. Pediatr Res 48(5):581-5 | |