P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1594

This family has 14 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 2 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/OrthoMCL1594
14 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_175284.2 · TAIR:locus:2198030 (T1N15_12 · AT1G48510 · T1N15.12)⌘
A. thalianaNCBI:NP_566592.1 · TAIR:locus:2088510 (AT3G17910 · SURF1 · MEB5.13)SURFEIT 1⌘
C. elegansWB:WBGene00004787 · UniProtKB:Q9N5N8
D. rerioUniProtKB:A5WUL6 · ZFIN:ZDB-GENE-041108-2 (surf1)surfeit 1⌘
D. discoideumUniProtKB:Q556J9 · dictyBase:DDB_G0272889
D. discoideumUniProtKB:Q556J9 · dictyBase:DDB_G0274001
D. melanogasterUniProtKB:Q9U4F3 · FB:FBgn0029117 (CG9943 · BcDNA:GH23574 · Surf1)Surfeit 1 · Surfeit locus protein 1⌘
G. gallusENTREZ:417157 · UniProtKB:Q800L1 (Q800L1 · IPI00571267 · SURF1 · SURF1_CHICK · SURF-1)Surfeit locus protein 1⌘
H. sapiensENSEMBL:ENSG00000148290 · UniProtKB:Q15526 (IPI00018034 · IPI00642942 · Q15526 · SURF1_HUMAN · SURF1 · SURF-1)Surfeit locus protein 1⌘
M. musculusUniProtKB:P09925 · MGI:MGI:98443 (Surf-1 · Surf1)surfeit gene 1⌘
R. norvegicusUniProtKB:Q9QXU2 · RGD:620527 (Surf1)surfeit 1⌘
R. norvegicusUniProtKB:Q9QXU2 · RGD:1561980 (Surf4)surfeit 4⌘
S. cerevisiaeUniProtKB:P53266 · SGD:S000003344 (YGR112W · SHY1)Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV)⌘
S. pombeUniProtKB:Q9Y810 · GeneDB_Spombe:SPBC1215.01 (shy1 · SPBC1215.01)SURF-family protein Shy1⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (2)
ENSEMBL:ENSG00000148290 · UniProtKB:Q15526#220110 MITOCHONDRIAL COMPLEX IV DEFICIENCY;;CYTOCHROME c OXIDASE DEFICIENCY;;COX DEFICIENCY
UniProtKB:P53266 · SGD:S000003344#256000 LEIGH SYNDROME; LS;;NECROTIZING ENCEPHALOPATHY, INFANTILE SUBACUTE, OF LEIGH; SNELEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX II DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX III DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX IV DEFICIENCY, INCLUDED;;LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX V DEFICIENCY, INCLUDED
SGD Disease Papers (6)
UniProtKB:P53266 · SGD:S000003344PMID:18045776 Fontanesi F, et al. (2008) Transcriptional activators HAP/NF-Y rescue a cytochrome c oxidase defect in yeast and human cells. Hum Mol Genet 17(6):775-88
PMID:12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
PMID:11782424 Barrientos A, et al. (2002) Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome. EMBO J 21(1-2):43-52
PMID:11579424 Shoubridge EA (2001) Cytochrome c oxidase deficiency. Am J Med Genet 106(1):46-52
PMID:11389896 Nijtmans LG, et al. (2001) Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeast. FEBS Lett 498(1):46-51
PMID:11044474 Robinson BH (2000) Human cytochrome oxidase deficiency. Pediatr Res 48(5):581-5
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