P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1572

This family has 14 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Escherichia coli, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/OrthoMCL1572
14 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_849779.1 · TAIR:locus:2203771 (AT3BETAHSD/D · T3F24_9 · AT3BETAHSD/D1 · T3F24.9 · AT1G47290)3BETA-HYDROXYSTEROID-DEHYDROGENASE/DECARBOXYLASE ISOFORM 1⌘
A. thalianaNCBI:NP_180194.2 · TAIR:locus:2057786 (AT3BETAHSD/D · AT3BETAHSD/D2 · AT2G26260 · T1D16_10 · T1D16.10)3BETA-HYDROXYSTEROID-DEHYDROGENASE/DECARBOXYLASE ISOFORM 2⌘
A. thalianaNCBI:NP_565998.1 · TAIR:locus:2058223 (T1O24.16 · AT2G43420)⌘
C. elegansWB:WBGene00022616 (hsd-3 · ZC449.6) · UniProtKB:A4UVJ7⌘
C. elegansWB:WBGene00012394 (Y6B3B.11 · hsd-1) · UniProtKB:Q9XWF0⌘
D. rerioUniProtKB:Q566U2 · ZFIN:ZDB-GENE-050417-163 (nsdhl)NAD(P) dependent steroid dehydrogenase-like⌘
D. discoideumUniProtKB:Q54TU9 · dictyBase:DDB_G0281487 (DDB_G0281487)3beta-hydroxysteroid dehydrogenase, putative sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)⌘
E. coliUniProtKB:P75821 · ECOLI:G6453-MONOMER (b0868 · YbjS · ybjS · ECK0859)predicted NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain⌘
G. gallusNCBI:XP_420279 · ENTREZ:422302
H. sapiensENSEMBL:ENSG00000147383 · UniProtKB:Q15738 (Q15738 · H105E3 · IPI00019407 · NSDHL_HUMAN · NSDHL)Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating⌘
M. musculusUniProtKB:Q9R1J0 · MGI:MGI:1099438 (striated · Nsdhl · XAP104 · H105E3 · Str · Bpa)NAD(P) dependent steroid dehydrogenase-like · bare patches⌘
R. norvegicusUniProtKB:Q5PPL3 · RGD:1359337 (Nsdhl)NAD(P) dependent steroid dehydrogenase-like⌘
S. cerevisiaeUniProtKB:P53199 · SGD:S000002969 (ERG26 · YGL001C)C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis⌘
S. pombeUniProtKB:O43050 · GeneDB_Spombe:SPBC3F6.02c (SPBC3F6.02c)3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase⌘
ProteinPublicationCurator Notes
UniProtKB:P53199 · SGD:S000002969PMID:14567972 Lucas ME, et al. Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast. Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33.The M. musculus protein Q9R1J0 complements a homologous mutation in S. cerevisiae.
UniProtKB:P53199 · SGD:S000002969PMID:14567972 Lucas ME, et al. Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast. Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33.The M. musculus protein Nsdhl complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
ENSEMBL:ENSG00000147383 · UniProtKB:Q15738#308050 CONGENITAL HEMIDYSPLASIA WITH ICHTHYOSIFORM ERYTHRODERMA AND LIMBDEFECTS;;CHILD SYNDROME;;ICHTHYOSIFORM ERYTHRODERMA, UNILATERAL, WITH IPSILATERAL MALFORMATIONS,ESPECIALLY ABSENCE DEFORMITY OF LIMBS
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