This family has 14 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 3 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| A. thaliana | NCBI:NP_188247.2 · TAIR:locus:2094912 (MYA6.7 · AT3G16260) |  | |
| A. thaliana | NCBI:NP_175628.2 · TAIR:locus:2037430 (F9I5.1 · AT1G52160 · F9I5_1) | | |
| C. elegans | WB:WBGene00001983 (hoe-1 · E04A4.4) · UniProtKB:O44476 | | |
| D. rerio | ZFIN:ZDB-GENE-041111-227 (im:7145112) · UniProtKB:Q6DG69 | | |
| D. discoideum | NCBI:EDR41096.1 · dictyBase:DDB_G0277337 (DDB_G0277337) | beta-lactamase family protein | |
| D. discoideum | UniProtKB:Q54FR8 · dictyBase:DDB_G0290623 (DDB_G0290623) | Similar to Mus musculus (Mouse). DNA segment, Chr 11, Wayne state University 80, expressed. | |
| D. discoideum | UniProtKB:Q551E0 · dictyBase:DDB_G0276633 (DDB_G0276633) | Similar to Mus musculus (Mouse). DNA segment, Chr 11, Wayne state University 80, expressed. | |
| D. melanogaster | UniProtKB:Q8MKW7 · FB:FBgn0028426 (JhI-1 · JHI-1 · CG3298 · dRNaseZ) | Juvenile hormone-inducible protein 1 · tRNase Z | |
| G. gallus | NCBI:XP_415584 · ENTREZ:417313 | ||
| H. sapiens | ENSEMBL:ENSG00000006744 · UniProtKB:Q9BQ52 (ELAC2 · RNZ2_HUMAN · IPI00398822 · HPC2 · Q9BQ52 · IPI00398823 · IPI00396627) | Zinc phosphodiesterase ELAC protein 2 | |
| M. musculus | UniProtKB:Q80Y81 · MGI:MGI:1890496 (D11Wsu80e · Elac2) | elaC homolog 2 (E. coli) | |
| R. norvegicus | UniProtKB:Q8CGS5 · RGD:628882 (Elac2) | elaC homolog 2 (E. coli) | |
| S. cerevisiae | UniProtKB:P36159 · SGD:S000001787 (TRZ1 · YKR079C) | tRNA 3'-end processing endonuclease tRNase Z | |
| S. pombe | UniProtKB:Q10155 · GeneDB_Spombe:SPAC1D4.10 (SPAC1D4.10) | tRNA endonuclease | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:P36159 · SGD:S000001787 |  23849775 Haack TB, et al. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Am J Hum Genet. 2013 Aug 8;93(2):211-23. | The H. sapiens protein ELAC2 was expressed in S. cerevisiae, but complementation was not directly tested. | |
| UniProtKB:P36159 · SGD:S000001787 | 15892892 Chen Y, et al. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol. 2005;6(1):12. | The H. sapiens protein ELAC2 does not complement a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |
| OMIM (1) | |
|---|---|
| UniProtKB:P36159 · SGD:S000001787 | #176807 PROSTATE CANCER |
| SGD Disease Papers (3) | |
| UniProtKB:P36159 · SGD:S000001787 | 15892892 Chen Y, et al. (2005) Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol 6(1):12 |
| 12711671 Takaku H, et al. (2003) A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. Nucleic Acids Res 31(9):2272-8 | |
| 11175785 Tavtigian SV, et al. (2001) A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet 27(2):172-80 | |