This family has 14 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 3 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.
Protein | Publication | Curator Notes | |
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UniProtKB:P36159 · SGD:S000001787 | 23849775 Haack TB, et al. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Am J Hum Genet. 2013 Aug 8;93(2):211-23. | The H. sapiens protein ELAC2 was expressed in S. cerevisiae, but complementation was not directly tested. |
UniProtKB:P36159 · SGD:S000001787 | 15892892 Chen Y, et al. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol. 2005;6(1):12. | The H. sapiens protein ELAC2 does not complement a homologous mutation in S. cerevisiae. |
OMIM (1) |
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UniProtKB:P36159 · SGD:S000001787 | #176807 PROSTATE CANCER |
SGD Disease Papers (3) |
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UniProtKB:P36159 · SGD:S000001787 | 15892892 Chen Y, et al. (2005) Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol 6(1):12 |
12711671 Takaku H, et al. (2003) A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. Nucleic Acids Res 31(9):2272-8 |
11175785 Tavtigian SV, et al. (2001) A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet 27(2):172-80 |