P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1557

This family has 14 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 3 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL1557
14 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_188247.2 · TAIR:locus:2094912 (MYA6.7 · AT3G16260)⌘
A. thalianaNCBI:NP_175628.2 · TAIR:locus:2037430 (F9I5.1 · AT1G52160 · F9I5_1)⌘
C. elegansWB:WBGene00001983 (hoe-1 · E04A4.4) · UniProtKB:O44476⌘
D. rerioZFIN:ZDB-GENE-041111-227 (im:7145112) · UniProtKB:Q6DG69⌘
D. discoideumNCBI:EDR41096.1 · dictyBase:DDB_G0277337 (DDB_G0277337)beta-lactamase family protein⌘
D. discoideumUniProtKB:Q54FR8 · dictyBase:DDB_G0290623 (DDB_G0290623)Similar to Mus musculus (Mouse). DNA segment, Chr 11, Wayne state University 80, expressed.⌘
D. discoideumUniProtKB:Q551E0 · dictyBase:DDB_G0276633 (DDB_G0276633)Similar to Mus musculus (Mouse). DNA segment, Chr 11, Wayne state University 80, expressed.⌘
D. melanogasterUniProtKB:Q8MKW7 · FB:FBgn0028426 (JhI-1 · JHI-1 · CG3298 · dRNaseZ)Juvenile hormone-inducible protein 1 · tRNase Z⌘
G. gallusNCBI:XP_415584 · ENTREZ:417313
H. sapiensENSEMBL:ENSG00000006744 · UniProtKB:Q9BQ52 (ELAC2 · RNZ2_HUMAN · IPI00398822 · HPC2 · Q9BQ52 · IPI00398823 · IPI00396627)Zinc phosphodiesterase ELAC protein 2⌘
M. musculusUniProtKB:Q80Y81 · MGI:MGI:1890496 (D11Wsu80e · Elac2)elaC homolog 2 (E. coli)⌘
R. norvegicusUniProtKB:Q8CGS5 · RGD:628882 (Elac2)elaC homolog 2 (E. coli)⌘
S. cerevisiaeUniProtKB:P36159 · SGD:S000001787 (TRZ1 · YKR079C)tRNA 3'-end processing endonuclease tRNase Z⌘
S. pombeUniProtKB:Q10155 · GeneDB_Spombe:SPAC1D4.10 (SPAC1D4.10)tRNA endonuclease⌘
ProteinPublicationCurator Notes
UniProtKB:P36159 · SGD:S000001787PMID:23849775 Haack TB, et al. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Am J Hum Genet. 2013 Aug 8;93(2):211-23.The H. sapiens protein ELAC2 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P36159 · SGD:S000001787PMID:15892892 Chen Y, et al. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol. 2005;6(1):12.The H. sapiens protein ELAC2 does not complement a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P36159 · SGD:S000001787#176807 PROSTATE CANCER
SGD Disease Papers (3)
UniProtKB:P36159 · SGD:S000001787PMID:15892892 Chen Y, et al. (2005) Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. BMC Mol Biol 6(1):12
PMID:12711671 Takaku H, et al. (2003) A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease. Nucleic Acids Res 31(9):2272-8
PMID:11175785 Tavtigian SV, et al. (2001) A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet 27(2):172-80
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