P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1352

This family has 15 members: 3 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

15 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_565419.1 · TAIR:locus:2053928 (AT2G17520 · ATIRE1-2 · IRE1-2 · MJB20_8 · MJB20.8 · IRE1A)transmembrane protein kinase/ribonuclease · ARABIDOPSIS THALIANA INOSITOL REQUIRING 1-2 · INOSITOL REQUIRING 1-2⌘
A. thalianaNCBI:NP_187793.1 · TAIR:locus:2081551 (F26K24.16 · AT3G11870)⌘
A. thalianaNCBI:NP_568444.1 · TAIR:locus:2152886 (K16H17_7 · ATIRE1-1 · IRE1-1 · K16H17.7 · AT5G24360)INOSITOL REQUIRING 1-1 · ARABIDOPSIS THALIANA INOSITOL REQUIRING 1-1⌘
C. elegansWB:WBGene00002147 (C41C4.4 · ire-1) · UniProtKB:Q09499⌘
D. rerioZFIN:ZDB-GENE-050522-431 · UniProtKB:Q504E3
D. discoideumUniProtKB:Q55GJ2 · dictyBase:DDB_G0267650 (ireA)putative protein serine/threonine kinase, putative endoribonuclease, IRE family protein kinase⌘
G. gallusNCBI:XP_001234523 · ENTREZ:771230
H. sapiensENSEMBL:ENSG00000178607 · UniProtKB:O75460 (IRE1 · ERN1 · IPI00873219 · IPI00015974 · ERN1_HUMAN · O75460)Serine/threonine-protein kinase/endoribonuclease IRE1⌘
H. sapiensENSEMBL:ENSG00000134398 · UniProtKB:Q76MJ5 (IPI00456641 · Q76MJ5 · IRE2 · ERN2_HUMAN · ERN2)Serine/threonine-protein kinase/endoribonuclease IRE2⌘
M. musculusUniProtKB:Q9EQY0 · MGI:MGI:1930134 (Ire1p · Ire1alpha · Ire1a · Ern1)endoplasmic reticulum (ER) to nucleus signalling 1⌘
M. musculusUniProtKB:Q9Z2E3 · MGI:MGI:1349436 (Ern2 · Ire1b)endoplasmic reticulum (ER) to nucleus signalling 2⌘
R. norvegicusNCBI:XP_001081576 · RGD:1559716 (Ern1)endoplasmic reticulum to nucleus signaling 1⌘
R. norvegicusNCBI:XP_344960 · RGD:1308743 (Ern2)endoplasmic reticulum to nucleus signaling 2⌘
S. cerevisiaeUniProtKB:P32361 · SGD:S000001121 (IRE1 · ERN1 · YHR079C)Serine-threonine kinase and endoribonuclease⌘
S. pombeUniProtKB:O94537 · GeneDB_Spombe:SPAC167.01 (SPAC167.01 · ppk4 · ire1)serine/threonine protein kinase Ppk4/ sensor for unfolded proteins in the ER⌘
ProteinPublicationCurator Notes
UniProtKB:P32361 · SGD:S000001121PMID:15480788 Valkonen M, et al. The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei. Mol Genet Genomics. 2004 Nov;272(4):443-51.The T. reesei protein IRE1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P32361 · SGD:S000001121PMID:12040100 Okushima Y, et al. Isolation and characterization of a putative transducer of endoplasmic reticulum stress in Oryza sativa. Plant Cell Physiol. 2002 May;43(5):532-9.The O. sativa protein OsIre1 complements a homologous mutation in S. cerevisiae. The N-terminal domain of O. sativa OsIre1 complements a yeast ire1 null mutant.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
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