P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL12959

This family has 4 members: 1 Danio rerio, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL12959
4 members.
OrganismProtein (Synonyms)DescriptionAmiGO
D. rerioUniProtKB:Q6P0D4 · ZFIN:ZDB-GENE-030131-6540 (vapa)VAMP (vesicle-associated membrane protein)-associated protein A⌘
S. cerevisiaeUniProtKB:Q6Q595 · SGD:S000007228 (YBL091C-A · SCS22)Protein involved in regulation of phospholipid metabolism⌘
S. cerevisiaeUniProtKB:P40075 · SGD:S000000922 (SCS2 · YER120W)Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog⌘
S. pombeUniProtKB:O60119 · GeneDB_Spombe:SPBC16G5.05c (SPBC16G5.05c)MSP domain⌘
ProteinPublicationCurator Notes
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein Q9P0L0 complements a homologous mutation in S. cerevisiae. This paper shows partial complementation of a yeast scs2 null mutant by H. sapiens VAP-A (Q9P0L0).
UniProtKB:P40075 · SGD:S000000922PMID:15668246 Loewen CJ, et al. A highly conserved binding site in vesicle-associated membrane protein-associated protein (VAP) for the FFAT motif of lipid-binding proteins. J Biol Chem. 2005 Apr 8;280(14):14097-104.The H. sapiens protein VAPA complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
SGD Disease Papers (2)
UniProtKB:P40075 · SGD:S000000922PMID:15372378 Nishimura AL, et al. (2004) A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am J Hum Genet 75(5):822-31
UniProtKB:P40075 · SGD:S000000922PMID:18468439 Lev S, et al. (2008) The VAP protein family: from cellular functions to motor neuron disease. Trends Cell Biol 18(6):282-90
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