P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1223

This family has 16 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 4 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/OrthoMCL1223
16 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_197058.2 · TAIR:locus:2180942 (AT5G15540 · T20K14.150 · SCC2 · EMB2773 · T20K14_150 · ATSCC2)SISTER-CHROMATID COHESION 2 · ARABIDOPSIS THALIANA SISTER-CHROMATID COHESION 2 · EMBRYO DEFECTIVE 2773⌘
C. elegansWB:WBGene00004166 (Y43H11AL.3 · pqn-85) · UniProtKB:Q95XZ5⌘
D. rerioENSEMBL:ENSDARP00000081088
D. rerioUniProtKB:A2BGN3 · ENSEMBL:ENSDARG00000061074
D. discoideumUniProtKB:Q54RK7 · dictyBase:DDB_G0283099 (DDB_G0283099)nipped-B protein, HEAT repeat-containing protein, armadillo-like helical domain-containing protein⌘
D. melanogasterUniProtKB:Q7PLI2 · FB:FBgn0026401 (Nipped · CG17704 · Nipped-B · l(2)02047 · CG40281)Nipped B⌘
G. gallusNCBI:XP_424627 · ENTREZ:427025
G. gallusNCBI:XP_001234650 · ENTREZ:771363
G. gallusNCBI:XP_423708 · ENTREZ:426031
G. gallusNCBI:XP_425012 · ENTREZ:427439
H. sapiensENSEMBL:ENSG00000164190 · UniProtKB:Q6KC79 (IPI00436632 · IPI00436634 · NIPBL · IPI00026466 · IDN3 · NIPBL_HUMAN · Q6KC79)Nipped-B-like protein⌘
M. musculusUniProtKB:Q6KCD5 · MGI:MGI:1913976 (Nipbl)Nipped-B homolog (Drosophila)⌘
R. norvegicusNCBI:XP_001056725 · RGD:1595401 (LOC681423)similar to delangin isoform A⌘
R. norvegicusNCBI:XP_238213 · RGD:1306393 (NIPBL)Nipped-B homolog (Drosophila)⌘
S. cerevisiaeUniProtKB:Q04002 · SGD:S000002588 (SCC2 · YDR180W)Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes⌘
S. pombeUniProtKB:Q09725 · GeneDB_Spombe:SPAC31A2.05c (SPAC31A2.05c · mis4)cohesin loading factor Mis4⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:Q04002 · SGD:S000002588#122470 CORNELIA DE LANGE SYNDROME 1; CDLS1;;CDLS;;CDL;;TYPUS DEGENERATIVUS AMSTELODAMENSIS;;DE LANGE SYNDROME;;BRACHMANN-DE LANGE SYNDROME; BDLS
SGD Disease Papers (3)
UniProtKB:Q04002 · SGD:S000002588PMID:16682347 Watrin E, et al. (2006) Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol 16(9):863-74
PMID:16100726 Kaur M, et al. (2005) Precocious sister chromatid separation (PSCS) in Cornelia de Lange syndrome. Am J Med Genet A 138(1):27-31
PMID:15146185 Tonkin ET, et al. (2004) NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome. Nat Genet 36(6):636-41
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