P-POD: Princeton Protein Orthology Database: GO3/OrthoMCL1189

This family has 16 members: 2 Arabidopsis thaliana, 1 Caenorhabditis elegans, 3 Danio rerio, 2 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 2 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

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GO3/OrthoMCL1189
16 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_179329.1 · TAIR:locus:2827622 (AT2G17370 · F5J6.1 · HMGR2 · F5J6_1 · HMG2)3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE 2 · 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2⌘
A. thalianaNCBI:NP_177775.2 · TAIR:locus:2011656 (HMG1 · HMGR1 · AT1G76490 · F15M4.1)HMG-COA REDUCTASE · 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE 1 · 3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE · HYDROXY METHYLGLUTARYL COA REDUCTASE 1⌘
C. elegansWB:WBGene00017268 (F08F8.2) · UniProtKB:Q19207⌘
D. rerioENSEMBL:ENSDARG00000052734 · UniProtKB:A2BGX2
D. rerioUniProtKB:Q1ECY4 · ZFIN:ZDB-GENE-040401-2 (hmgcra)3-hydroxy-3-methylglutaryl-Coenzyme A reductase a⌘
D. rerioENSEMBL:ENSDARG00000059301 · UniProtKB:Q58ER2
D. discoideumUniProtKB:P34135 · dictyBase:DDB_G0269142 (hmgA)hmg CoA reductase A, hydroxymethylglutaryl CoA reductase⌘
D. discoideumUniProtKB:P34136 · dictyBase:DDB_G0276615 (hmgB)hydroxymethylglutaryl CoA reductase, hmg CoA reductase B⌘
D. melanogasterUniProtKB:P14773 · FB:FBgn0001205 (BcDNA:LD15354 · HMGCR · l(3)01152 · Hmgcr · columbus · Hmg-CoA-reductase · CG10367 · HMGCoAr · hmgcr · bro1 · Hmg · HMGCR_Dm · HMGCoAR · HmG-CoAR · Clb · bs32f05.y1 · HMGCoARr · clb · hmgc · DmHMG-CoAr)3-hydroxy-3-methylglutaryl coenzyme A reductase · HMG-CoA reductase · HMG Coenzyme A reductase · 3-Hydroxy-3-Methylglutaryl CoA Reductase · HMGCoA reductase · HMGCo-A reductase⌘
G. gallusUniProtKB:Q76CF0 (IPI00821095 · Q76CF0 · HMGR) · ENTREZ:395145⌘
H. sapiensENSEMBL:ENSG00000113161 · UniProtKB:P04035 (IPI00221382 · HMGCR · HMDH_HUMAN · IPI00021770 · P04035)3-hydroxy-3-methylglutaryl-coenzyme A reductase⌘
M. musculusUniProtKB:Q01237 · MGI:MGI:96159 (Red · Hmgcr · HMG-CoAR)3-hydroxy-3-methylglutaryl-CoA reductase · 3-hydroxy-3-methylglutaryl-Coenzyme A reductase⌘
R. norvegicusUniProtKB:P51639 · RGD:2803 (Hmgcr)3-hydroxy-3-methylglutaryl-Coenzyme A reductase⌘
S. cerevisiaeUniProtKB:P12683 · SGD:S000004540 (YML075C · HMG1)One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis⌘
S. cerevisiaeUniProtKB:P12684 · SGD:S000004442 (YLR450W · HMG2)One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis⌘
S. pombeUniProtKB:Q10283 · GeneDB_Spombe:SPCC162.09c (hmg1 · SPCC162.09c)3-hydroxy-3-methylglutaryl-CoA reductase Hmg1⌘
ProteinPublicationCurator Notes
UniProtKB:P12684 · SGD:S000004442PMID:14699057 Peña-Diaz J, et al. Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae. Mol Biol Cell. 2004 Mar;15(3):1356-63.The T. cruzi protein HMGR complements a homologous mutation in S. cerevisiae. T. cruzi HMGR complements a yeast hmg1 hmg2 double mutant.
UniProtKB:P12683 · SGD:S000004540PMID:14699057 Peña-Diaz J, et al. Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae. Mol Biol Cell. 2004 Mar;15(3):1356-63.The T. cruzi protein HMGR complements a homologous mutation in S. cerevisiae. T. cruzi HMGR complements a yeast hmg1 hmg2 double mutant.
UniProtKB:P12684 · SGD:S000004442PMID:19187128 Wysocka-Kapcinska M, et al. Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment. J Appl Microbiol. 2009 Mar;106(3):895-902.The H. sapiens protein HMGCR complements a homologous mutation in S. cerevisiae.
UniProtKB:P12684 · SGD:S000004442PMID:20041128 Leszczynska A, et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. PLoS One. 2009;4(12):e8499.The H. sapiens protein HMGCR complements a homologous mutation in S. cerevisiae.
UniProtKB:P12683 · SGD:S000004540PMID:19187128 Wysocka-Kapcinska M, et al. Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment. J Appl Microbiol. 2009 Mar;106(3):895-902.The H. sapiens protein HMGCR complements a homologous mutation in S. cerevisiae.
UniProtKB:P12683 · SGD:S000004540PMID:20041128 Leszczynska A, et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. PLoS One. 2009;4(12):e8499.The H. sapiens protein HMGCR complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P12683 · SGD:S000004540+142910 3-@HYDROXY-3-METHYLGLUTARYL-CoA REDUCTASE; HMGCR;;HMG-CoA REDUCTASELOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS3, INCLUDED; LDLCQ3, INCLUDED;;STATINS, ATTENUATED CHOLESTEROL LOWERING BY, INCLUDED
SGD Disease Papers (2)
UniProtKB:P12684 · SGD:S000004442PMID:19187128 Wysocka-Kapcinska M, et al. (2009) Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment. J Appl Microbiol 106(3):895-902
UniProtKB:P12684 · SGD:S000004442PMID:19187128 Wysocka-Kapcinska M, et al. (2009) Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment. J Appl Microbiol 106(3):895-902
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