P-POD: Princeton Protein Orthology Database: GO3/Nens921

This family has 23 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 2 Dictyostelium discoideum, 2 Drosophila melanogaster, 2 Escherichia coli, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Nens921
23 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2161670 (MCO15_2 · MCO15.2 · AT5G55070) · NCBI:NP_200318.1⌘
A. thalianaNCBI:NP_187341.1 · TAIR:locus:2083358 (F3E22.1 · BCE2 · AT3G06850 · LTA1 · DIN3)DARK INDUCIBLE 3⌘
A. thalianaNCBI:NP_567761.1 · TAIR:locus:2116432 (F10M23.250 · F10M23_250 · AT4G26910)⌘
C. elegansWB:WBGene00020950 (W02F12.5) · UniProtKB:O45148⌘
C. elegansWB:WBGene00014054 (ZK669.4) · UniProtKB:Q23571 (ZK669.4)Protein ZK669.4, confirmed by transcript evidence⌘⌘
D. rerioUniProtKB:Q5BKV3 · ZFIN:ZDB-GENE-050320-85 (dbt)dihydrolipoamide branched chain transacylase E2⌘
D. rerioUniProtKB:Q7ZVL3 · ZFIN:ZDB-GENE-030326-1 (dlst)dihydrolipoamide S-succinyltransferase⌘
D. discoideumUniProtKB:Q869Y7 · dictyBase:DDB_G0275029 (DLST · odhB)dihydrolipoamide S-succinyltransferase, 2-oxoglutarate dehydrogenase E2 component, dihydrolipoyllysine-residue succinyltransferase⌘
D. discoideumUniProtKB:Q54TR7 · dictyBase:DDB_G0281797 (bkdC)lipoamide acyltransferase, dihydrolipoyllysine-residue (2-methylpropanoyl) transferase, dihydrolipoyl transacylase, branched-chain alpha-keto acid dehydrogenase E2 component⌘
D. melanogasterFB:FBgn0037891 (CG5214) · UniProtKB:Q9VGQ1⌘
D. melanogasterFB:FBgn0030612 (CG5599) · UniProtKB:Q9VXY3⌘
E. coliUniProtKB:P0AFG6 · ECOLI:SUCB-LIPOATE (SucB · B0727 · SucB-lipoate)⌘
E. coliUniProtKB:P06959 · ECOLI:ACEF-LIPOATE (AceF-lipoate · ECK0114 · aceF · b0115)⌘
G. gallusUniProtKB:Q5F326 (RCJMB04_39i8 · IPI00592325 · Q5F326) · ENTREZ:423357⌘
G. gallusUniProtKB:Q98UJ6 (Q98UJ6 · IPI00570647) · ENTREZ:395374⌘
H. sapiensENSEMBL:ENSG00000137992 · UniProtKB:P11182 (P11182 · DBT · ODB2_HUMAN · BCATE2 · IPI00003944)Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial⌘
H. sapiensENSEMBL:ENSG00000119689 · UniProtKB:P36957 (DLST · P36957 · DLTS · ODO2_HUMAN · IPI00420108)Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial⌘
M. musculusUniProtKB:P53395 · MGI:MGI:105386 (Dbt · D3Wsu60e)dihydrolipoyl transacylase · dihydrolipoyllysine-residue (2-methylpropanoyl)transferase · dihydrolipoamide branched chain transacylase E2 · BCKAD E2⌘
M. musculusUniProtKB:Q9D2G2 · MGI:MGI:1926170 (Dlst)dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)⌘
R. norvegicusUniProtKB:Q01205 · RGD:1359615 (Dlst)dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)⌘
R. norvegicusUniProtKB:Q99PU6 · RGD:68403 (Dbt)dihydrolipoamide branched chain transacylase E2⌘
S. cerevisiaeUniProtKB:P19262 · SGD:S000002555 (YDR148C · KGD2)Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle⌘
S. pombeUniProtKB:O94681 · GeneDB_Spombe:SPBC776.15c (SPBC776.15c)dihydrolipoamide S-succinyltransferase, e2 component of oxoglutarate dehydrogenase complex⌘

No functional conservation results.

DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
UniProtKB:P19262 · SGD:S000002555#248600 MAPLE SYRUP URINE DISEASE;;MSUD;;BRANCHED-CHAIN KETOACIDURIA;;BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE DEFICIENCY;;BCKD DEFICIENCY;;KETO ACID DECARBOXYLASE DEFICIENCYMAPLE SYRUP URINE DISEASE, CLASSIC, INCLUDED;;MAPLE SYRUP URINE DISEASE, INTERMEDIATE, INCLUDED;;MAPLE SYRUP URINE DISEASE, INTERMITTENT, INCLUDED;;MAPLE SYRUP URINE DISEASE, THIAMINE-RESPONSIVE, INCLUDED;;MAPLE SYRUP URINE DISEASE, E3-DEFICIENT, WITH LACTIC ACIDOSIS, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE IA, INCLUDED; MSUD1A, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE IB, INCLUDED; MSUD1B, INCLUDED;;MAPLE SYRUP URINE DISEASE, TYPE II, INCLUDED; MSUD2, INCLUDED; MAPLESYRUP URINE DISEASE, TYPE III, INCLUDED; MSUD3, INCLUDED;;LIPOAMIDE DEHYDROGENASE DEFICIENCY, LACTIC ACIDOSIS DUE TO;;LACTIC ACIDOSIS, CONGENITAL INFANTILE, DUE TO LAD DEFICIENCY, INCLUDED;;DIHYDROLIPOAMIDE DEHYDROGENASE DEFICIENCY, INCLUDED;;DLD DEFICIENCY, INCLUDED
SGD Disease Papers (1)
UniProtKB:P19262 · SGD:S000002555PMID:12134146 Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4
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