P-POD: Princeton Protein Orthology Database: GO3/Nens918

This family has 23 members: 3 Arabidopsis thaliana, 2 Caenorhabditis elegans, 2 Danio rerio, 1 Dictyostelium discoideum, 2 Drosophila melanogaster, 1 Escherichia coli, 2 Gallus gallus, 2 Homo sapiens, 2 Mus musculus, 2 Rattus norvegicus, 2 Saccharomyces cerevisiae, 2 Schizosaccharomyces pombe.

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GO3/Nens918
23 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_186877.2 · TAIR:locus:2076547 (F14P3.7 · F14P3_7 · AT3G02280)⌘
A. thalianaNCBI:NP_194183.1 · TAIR:locus:2121894 (F22K18_280 · AR1 · ATR1 · AT4G24520 · F22K18.280)ARABIDOPSIS CYTOCHROME REDUCTASE · ARABIDOPSIS P450 REDUCTASE 1⌘
A. thalianaNCBI:NP_849472.2 · TAIR:locus:2128951 (AT4G30210 · F9N11.60 · F9N11_60 · ATR2 · AR2)ARABIDOPSIS P450 REDUCTASE 2⌘
C. elegansWB:WBGene00001262 (K10D2.6 · emb-8) · UniProtKB:Q09590⌘
C. elegansWB:WBGene00001485 (Y113G7A.8 · fre-1) · UniProtKB:Q9U2Y8⌘
D. rerioUniProtKB:Q6PFP6 · ZFIN:ZDB-GENE-040426-1555 (ndor1)NADPH dependent diflavin oxidoreductase 1⌘
D. rerioUniProtKB:Q499B1 · ZFIN:ZDB-GENE-050809-121 (por)P450 (cytochrome) oxidoreductase⌘
D. discoideumUniProtKB:Q54B10 · dictyBase:DDB_G0293904 (DG1047 · redA)NADPH-cytochrome-P450 oxidoreductase⌘
D. melanogasterUniProtKB:Q27597 · FB:FBgn0015623 (P450 · Cpr · cpr · CPR · DmCPR · CG11567 · DMR · NCPR)Cytochrome P450 reductase · NADPH-cytochrome P450 oxidoreductase · P450 reductase⌘
D. melanogasterFB:FBgn0035890 (CG13667) · UniProtKB:Q9VSJ5⌘
E. coliUniProtKB:P38038 · ECOLI:ALPHACOMP-MONOMER (ECK2759 · b2764 · CysJ · cysJ)sulfite reductase flavoprotein subunit⌘
G. gallusNCBI:XP_415553 · ENTREZ:417280
G. gallusNCBI:XP_415768 · ENTREZ:417520
H. sapiensENSEMBL:ENSG00000127948 · UniProtKB:P16435 (P16435 · POR · NCPR_HUMAN · IPI00470467 · CYPOR)NADPH--cytochrome P450 reductase⌘
H. sapiensENSEMBL:ENSG00000188566 · UniProtKB:Q9UHB4 (NR1 · Q9UHB4 · IPI00791177 · NDOR1_HUMAN · IPI00748284 · NDOR1)NADPH-dependent diflavin oxidoreductase 1⌘
M. musculusUniProtKB:P37040 · MGI:MGI:97744 (Por · CPR · CYPOR)NADH cytochrome P450 oxydoreductase · P450 (cytochrome) oxidoreductase⌘
M. musculusUniProtKB:A2AI05 · MGI:MGI:1926047 (NR1 · Ndor1)NADPH dependent diflavin oxidoreductase 1⌘
R. norvegicusNCBI:XP_001072474 · RGD:1308479 (Ndor1)NADPH dependent diflavin oxidoreductase 1⌘
R. norvegicusUniProtKB:P00388 · RGD:68335 (Por)P450 (cytochrome) oxidoreductase⌘
S. cerevisiaeUniProtKB:P16603 · SGD:S000001084 (YHR042W · CPR1 · NCP1)NADP-cytochrome P450 reductase⌘
S. cerevisiaeUniProtKB:Q12181 · SGD:S000006252 (YPR048W · TAH18)Protein of unknown function that plays a pro-death role in response to oxidative stress⌘
S. pombeUniProtKB:P36587 · GeneDB_Spombe:SPBC29A10.01 (ccr1 · SPBC29A10.01 · SPBC365.17)NADPH-cytochrome p450 reductase⌘
S. pombeUniProtKB:O94613 · GeneDB_Spombe:SPAC1296.06 (SPAC1296.06)NADPH-dependent diflavin oxidoreductase (predicted) · NADPH-dependent diflavin oxidoreductase⌘
ProteinPublicationCurator Notes
UniProtKB:P16603 · SGD:S000001084PMID:15849785 He F, et al. Cloning and heterologous expression of the NADPH cytochrome P450 oxidoreductase genes from an industrial dicarboxylic acid-producing Candida tropicalis. Yeast. 2005 Apr 30;22(6):481-91.The C. tropicalis protein CPR-a complements a homologous mutation in S. cerevisiae.
UniProtKB:P16603 · SGD:S000001084PMID:1544575 Bligh HF, et al. Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae. Gene. 1992 Jan 2;110(1):33-9.The R. norvegicus protein cytochrome c P450 reductase was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P16603 · SGD:S000001084PMID:9468503 Venkateswarlu K, et al. The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. J Biol Chem. 1998 Feb 20;273(8):4492-6.The H. sapiens protein CYP51 (protein ID unknown) was expressed in S. cerevisiae, but complementation was not directly tested. This paper describes the biochemical characterization of human CYP51 expressed in and NCP1 strain.
UniProtKB:P16603 · SGD:S000001084PMID:15849785 He F, et al. Cloning and heterologous expression of the NADPH cytochrome P450 oxidoreductase genes from an industrial dicarboxylic acid-producing Candida tropicalis. Yeast. 2005 Apr 30;22(6):481-91.The C. tropicalis protein CPR-b complements a homologous mutation in S. cerevisiae.
UniProtKB:Q12181 · SGD:S000006252PMID:20802492 Netz DJ, et al. Tah18 transfers electrons to Dre2 in cytosolic iron-sulfur protein biogenesis. Nat Chem Biol. 2010 Oct;6(10):758-65.The H. sapiens protein NDOR1 complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
ENSEMBL:ENSG00000127948 · UniProtKB:P16435#201750 POR DEFICIENCY;;CYTOCHROME P450 OXIDOREDUCTASE DEFICIENCY;;ANTLEY-BIXLER SYNDROME-LIKE PHENOTYPE WITH DISORDERED STEROIDOGENESISDISORDERED STEROIDOGENESIS DUE TO CYTOCHROME P450 OXIDOREDUCTASE DEFICIENCY,INCLUDED;;ADRENAL HYPERPLASIA, CONGENITAL, DUE TO CYTOCHROME P450 OXIDOREDUCTASEDEFICIENCY, INCLUDED
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