P-POD: Princeton Protein Orthology Database: GO3/Nens82

This family has 98 members: 17 Arabidopsis thaliana, 7 Caenorhabditis elegans, 8 Danio rerio, 10 Dictyostelium discoideum, 5 Drosophila melanogaster, 4 Gallus gallus, 7 Homo sapiens, 14 Mus musculus, 16 Rattus norvegicus, 6 Saccharomyces cerevisiae, 4 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (4)
• Download Files (5)
• Disease References (1)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

98 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	TAIR:locus:2028005 (F26F24.28 · F26F24_28 · AT1G23410) · NCBI:NP_173755.1
A. thaliana	NCBI:NP_564379.2 · TAIR:locus:2197525 (T19E23.13 · AT1G31340 · NEDD8 · RUB1 · T19E23_13 · ATRUB1)	RELATED TO UBIQUITIN 1 · ARABIDOPSIS THALIANA RELATED TO UBIQUITIN 1
A. thaliana	NCBI:NP_849299.1 · TAIR:locus:2115663 (C17L7.240 · C17L7_240 · UBQ10 · AT4G05320)	POLYUBIQUITIN 10
A. thaliana	NCBI:NP_566357.1 · TAIR:locus:2074909 (AT3G09790 · F11F8.38 · UBQ8)
A. thaliana	NCBI:NP_566969.1 · TAIR:locus:2079924 (ERD16 · UBQ1 · F3C22.8 · HAP4 · AT3G52590 · EMB2167)	EMBRYO DEFECTIVE 2167 · UBIQUITIN EXTENSION PROTEIN 1 · HAPLESS 4 · EARLY-RESPONSIVE TO DEHYDRATION 16
A. thaliana	NCBI:NP_849292.1 · TAIR:locus:2140200 (T5J8.21 · UBQ14 · AT4G02890 · T5J8_21)
A. thaliana	NCBI:NP_568552.1 · TAIR:locus:2151774 (K12B20.90 · UBQ9 · K12B20_90 · AT5G37640)
A. thaliana	NCBI:NP_851029.1 · TAIR:locus:2143548 (UBQ3 · F15A17.270 · F15A17_270 · AT5G03240)	POLYUBIQUITIN 3 PROTEIN · POLYUBIQUITIN 3
A. thaliana	NCBI:NP_568397.1 · TAIR:locus:2180434 (T1M15.20 · AT5G20620 · UBQ4 · T1M15_20)
A. thaliana	NCBI:NP_172662.1 · TAIR:locus:2008950 (F12F1_15 · F12F1.15 · RUB3 · AT1G11980)	UBIQUITIN-RELATED PROTEIN 3
A. thaliana	NCBI:NP_565812.1 · TAIR:locus:505006295 (UBQ7 · AT2G35635 · RUB2)	RELATED TO UBIQUITIN 2
A. thaliana	NCBI:NP_176714.1 · TAIR:locus:2206310 (UBQ13 · T8F5.13 · AT1G65350 · T8F5_13)
A. thaliana	NCBI:NP_566095.1 · TAIR:locus:2041459 (UBQ6 · AT2G47110 · F14M4.6)
A. thaliana	NCBI:NP_565836.1 · TAIR:locus:2053496 (AT2G36170 · F9C22_10 · F9C22.10)
A. thaliana	NCBI:NP_191784.1 · TAIR:locus:2098003 (T17J13.210 · UBQ5 · AT3G62250)	ubiquitin 5
A. thaliana	NCBI:NP_567286.1 · TAIR:locus:2138386 (UBQ11 · AT4G05050 · C17L7.6)	UBIQUITIN 11
A. thaliana	NCBI:NP_564675.1 · TAIR:locus:2827139 (AT1G55060 · T7N22.10 · UBQ12)	UBIQUITIN 12
C. elegans	WB:WBGene00003587 (F45H11.2 · ned-8) · UniProtKB:Q93725 (F45H11.2 · NEDD8_CAEEL · NEDD8 · ned-8)
C. elegans	WB:WBGene00006725 (H06I04.4 · ubl-1) · UniProtKB:P37165
C. elegans	WB:WBGene00006727 (ubq-1 · F25B5.4) · UniProtKB:P14792 (ubq-2 · ubib · UBIQ_CAEEL · ubq-1 · F25B5.4 · ubia · ZK1010.1 · Ubiquitin)
C. elegans	UniProtKB:P14792 (ubq-2 · ubib · UBIQ_CAEEL · ubq-1 · F25B5.4 · ubia · ZK1010.1 · Ubiquitin) · WB:WBGene00006728 (ubq-2 · ZK1010.1)
C. elegans	WB:WBGene00009378 · UniProtKB:Q09557
C. elegans	WB:WBGene00018661 (F52C6.4) · UniProtKB:O44819
C. elegans	WB:WBGene00010654 · UniProtKB:Q9XUT3
D. rerio	ENSEMBL:ENSDARP00000088354
D. rerio	ENSEMBL:ENSDARG00000056851 · UniProtKB:A2BHB8
D. rerio	UniProtKB:Q3B7P7 · ZFIN:ZDB-GENE-051023-7 (uba52)	ubiquitin A-52 residue ribosomal protein fusion product 1
D. rerio	UniProtKB:Q6DGU4 · ZFIN:ZDB-GENE-040718-295 (nedd8l)	neural precursor cell expressed, developmentally down-regulated 8, like
D. rerio	ZFIN:ZDB-GENE-050411-10 (zgc:172187) · UniProtKB:Q6IS68
D. rerio	UniProtKB:Q7SXD9 · ZFIN:ZDB-GENE-030616-588 (nedd8)	neural precursor cell expressed, developmentally down-regulated 8
D. rerio	ZFIN:ZDB-GENE-030131-10018 (zgc:66168) · UniProtKB:Q7ZU62
D. rerio	ZFIN:ZDB-GENE-040426-1089 (zgc:56596) · UniProtKB:Q7ZWB2
D. discoideum	NCBI:EAL61494.1 · dictyBase:DDB_G0291928 (ubqI · ubiquitin)
D. discoideum	NCBI:EAL66269.1 · dictyBase:DDB_G0282295 (ubiquitin · ubqA)
D. discoideum	NCBI:EAL67635.1 · dictyBase:DDB_G0279721 (ubqH · ubiquitin)
D. discoideum	NCBI:EAL62704.1 · dictyBase:DDB_G0289449 (ubqF · ubiquitin)
D. discoideum	NCBI:EAL72079.1 · dictyBase:DDB_G0269458 (ubqJ · ubiquitin)
D. discoideum	NCBI:EAL63951.1 · dictyBase:DDB_G0286907 (ubqE · ubqD · ubiquitin)
D. discoideum	NCBI:EAL67035.1 · dictyBase:DDB_G0280755 (ubqB · rpl40)	ubiquitin/ribosomal protein L40 fusion protein
D. discoideum	NCBI:EAL66044.1 · dictyBase:DDB_G0282369 (rcdLL · veg116 · ubqG · ubiquitin)
D. discoideum	NCBI:EAL68884.1 · dictyBase:DDB_G0276765 (rps27a · ubqC)	ubiquitin/ribosomal protein S27a fusion protein
D. discoideum	UniProtKB:Q54XV3 · dictyBase:DDB_G0278711 (nedd8)	neddylin, ubiquitin-like protein Nedd8
D. melanogaster	UniProtKB:Q9VJ33 · FB:FBgn0032725 (nedd8 · CG10679 · Nedd8)	neural precursor cell-expressed developmentally downregulated
D. melanogaster	UniProtKB:P15357 · FB:FBgn0003942 (Ubiquitin-monomeric · UB3-D · ubiquitin · Ubiquitin · CG5271 · Ubi-m · DUb80 · Dub80 · mfs(2)31 · Ubi-f80 · mfs(2)48 · RpS27A · Ubiq · mfs48 · l(2)04820 · l(2)31Ei)	male female sterile 31 · Ubiquitin fusion 80 · Ribosomal protein S27A
D. melanogaster	FB:FBgn0003943 (DmUb · ubi63E · Ubp · Ubi-p · polyubiquitin · Ubi-p63E · ubiquitin · Ubiquitin-polymeric · Ubiquitin · Ubiquitin-63E · Ub · Ubiq · CG11624 · Ubip · Ubi63E · Ubi63p) · UniProtKB:P68198
D. melanogaster	FB:FBgn0038571 (CG7215 · CG32920) · UniProtKB:Q9VEC8
D. melanogaster	FB:FBgn0086558 (CG18282 · ubiquitin · CR32744 · Ubi-p5E · Ubiquitin · Ub · Ubiq · Ubiquitin-5E · CG32744) · UniProtKB:Q9W418
G. gallus	NCBI:NP_001072942 · ENTREZ:396425
G. gallus	NCBI:XP_415105 · ENTREZ:396190
G. gallus	NCBI:NP_990284 · ENTREZ:395796
G. gallus	UniProtKB:O42388 (O42388 · IPI00589085) · ENTREZ:395958
H. sapiens	ENSEMBL:ENSG00000129559 · UniProtKB:Q15843 (NEDD8 · Q15843 · NEDD8_HUMAN · IPI00020008)
H. sapiens	ENSEMBL:ENSG00000143947 · UniProtKB:P62979 (UBCEP1 · UBA80 · RS27A_HUMAN · P62979 · IPI00179330 · RPS27A)	40S ribosomal protein S27a
H. sapiens	ENSEMBL:ENSG00000206468 · UniProtKB:O15205 (UBD_HUMAN · O15205 · UBD · FAT10 · IPI00007405)	Ubiquitin D
H. sapiens	ENSEMBL:ENSG00000150991 · UniProtKB:P62988 (UBCEP1 · UBA80 · UBA52 · UBIQ_HUMAN · UBC · Ubiquitin · UBB · P62988 · IPI00798155 · UBCEP2 · RPS27A)
H. sapiens	UniProtKB:P62988 (UBCEP1 · UBA80 · UBA52 · UBIQ_HUMAN · UBC · Ubiquitin · UBB · P62988 · IPI00798155 · UBCEP2 · RPS27A) · ENSEMBL:ENSG00000170315
H. sapiens	ENSEMBL:ENSG00000102178 · UniProtKB:P11441 (GDX · DXS254E · P11441 · IPI00005658 · UBL4A_HUMAN · UBL4 · UBL4A)	Ubiquitin-like protein 4A
H. sapiens	ENSEMBL:ENSG00000187608 · UniProtKB:P05161 (UCRP_HUMAN · IPI00375631 · UCRP · ISG15 · P05161 · G1P2)	Interferon-induced 17 kDa protein
M. musculus	NCBI:XP_356994 · MGI:MGI:3648788
M. musculus	NCBI:XP_985698 · MGI:MGI:3644625
M. musculus	MGI:MGI:3643769 · NCBI:XP_997313
M. musculus	NCBI:NP_001098627 · MGI:MGI:3649356 (OTTMUSG00000004411)	predicted gene, OTTMUSG00000004411
M. musculus	NCBI:XP_915304 · MGI:MGI:3647845
M. musculus	NCBI:XP_889611 · MGI:MGI:3643614
M. musculus	NCBI:XP_001471736 · MGI:MGI:3809535
M. musculus	NCBI:XP_994469 · MGI:MGI:3643360
M. musculus	NCBI:XP_001002242 · MGI:MGI:3645406
M. musculus	UniProtKB:P29595 · MGI:MGI:97301 (Rub1 · Nedd8)	neural precursor cell expressed, developmentally down-regulated gene 8
M. musculus	UniProtKB:P62983 · MGI:MGI:1925544 (Rps27a)	ribosomal protein S27A
M. musculus	UniProtKB:P63072 · MGI:MGI:1344410 (Diubiquitin · Ubd · FAT10)	ubiquitin D
M. musculus	UniProtKB:P21126 · MGI:MGI:95049 (Gdx · DXHXS254E · Ubl4 · DXS254Eh)	ubiquitin-like 4
M. musculus	UniProtKB:Q64339 · MGI:MGI:1855694 (G1p2 · Isg15)	ISG15 ubiquitin-like modifier
R. norvegicus	NCBI:XP_001066030 · RGD:1588826 (LOC688462)	similar to ribosomal protein S27a
R. norvegicus	NCBI:XP_001060577 · RGD:1598012 (LOC681260)	similar to ribosomal protein S27a
R. norvegicus	NCBI:XP_216605 · RGD:1310312
R. norvegicus	NCBI:XP_574121 · RGD:1564290 (RGD1564290)	similar to ribosomal protein S27a
R. norvegicus	NCBI:XP_001080565 · RGD:1597537
R. norvegicus	NCBI:XP_001068457 · RGD:1595237
R. norvegicus	NCBI:XP_001060776 · RGD:1598057 (LOC681214)	similar to ribosomal protein S27a
R. norvegicus	NCBI:XP_001057026 · RGD:1598094 (LOC679976)	similar to ribosomal protein S27a
R. norvegicus	NCBI:XP_215228 · RGD:1563983 (Ubl4)	ubiquitin-like 4
R. norvegicus	NCBI:XP_001053937 · RGD:1560997 (RGD1560997)	similar to ribosomal protein S27a
R. norvegicus	UniProtKB:Q71UE8 · RGD:3158 (Nedd8)	neural precursor cell expressed, developmentally down-regulated 8
R. norvegicus	UniProtKB:P62982 · RGD:620240 (Rps27a)	ribosomal protein S27a
R. norvegicus	UniProtKB:Q921A3 · RGD:69418 (Ubd)	ubiquitin D
R. norvegicus	UniProtKB:Q63429 · RGD:621244 (Ubc)	ubiquitin C
R. norvegicus	UniProtKB:Q63654 · RGD:621562 (Ubb)	ubiquitin B
R. norvegicus	NCBI:XP_577989 · RGD:1562896
S. cerevisiae	NCBI:NP_013061 · SGD:S000003962 (UB14 · UBI4 · YLL039C · SCD2)	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system
S. cerevisiae	UniProtKB:Q12285 · SGD:S000005471 (GET5 · MDY2 · TMA24 · YOL111C)	Protein required for efficient mating
S. cerevisiae	UniProtKB:P05759 · SGD:S000004157 (RPS37 · RPS31 · YLR167W · UBI3)	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin
S. cerevisiae	UniProtKB:Q03919 · SGD:S000002546 (RUB1 · YDR139C)	Ubiquitin-like protein with similarity to mammalian NEDD8
S. cerevisiae	UniProtKB:P61864 · SGD:S000001802 (UB12 · RPL40B · UBI2 · CEP52B · YKR094C)	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40
S. cerevisiae	UniProtKB:P61864 · SGD:S000001410 (UBI1 · YIL148W · CEP52A · RPL40A · UB11)	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40
S. pombe	UniProtKB:P0C016 · GeneDB_Spombe:SPAC6G10.11c (SPAC6G10.11c · ubi3)	ribosomal-ubiquitin fusion protein Ubi3
S. pombe	GeneDB_Spombe:SPBC337.08c (ubi4 · SPBC337.08c · ubiquitin) · UniProtKB:P0C014
S. pombe	UniProtKB:O14399 · GeneDB_Spombe:SPBC12D12.08c (ubl1 · nedd8 · SPBC24C6.01c · ned8 · SPBC12D12.08c)	ubiquitin-like protein modifier Ned8
S. pombe	UniProtKB:Q9HDZ4 · GeneDB_Spombe:SPAC589.10c (SPAC589.10c)	ribomal-ubiquitin fusion protein Ubi5

Protein	Publication	Curator Notes
UniProtKB:P61864 · SGD:S000001410	15790562 Shang F, et al. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27;280(21):20365-74.	The S. cerevisiae protein RPL40A was expressed in E. coli, but complementation was not directly tested. This paper describes the biochemical characterization of ubiquitins produced in several expression systems.
UniProtKB:P61864 · SGD:S000001802	15790562 Shang F, et al. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27;280(21):20365-74.	The S. cerevisiae protein RPL40B was expressed in E. coli, but complementation was not directly tested. This paper describes the biochemical characterization of ubiquitins produced in several expression systems.
UniProtKB:P05759 · SGD:S000004157	15790562 Shang F, et al. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27;280(21):20365-74.	The S. cerevisiae protein RPS31 was expressed in E. coli, but complementation was not directly tested. This paper describes the biochemical characterization of ubiquitins produced in several expression systems.
NCBI:NP_013061 · SGD:S000003962	15790562 Shang F, et al. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005 May 27;280(21):20365-74.	The S. cerevisiae protein UBI4 was expressed in E. coli, but complementation was not directly tested. This paper describes the biochemical characterization of ubiquitins produced in several expression systems.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

SGD Disease Papers (1)
NCBI:NP_013061 · SGD:S000003962	12709439 Welsch CA, et al. (2003) Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. J Biol Chem 278(29):26976-82