P-POD: Princeton Protein Orthology Database: GO3/Nens5520

This family has 7 members: 2 Arabidopsis thaliana, 1 Dictyostelium discoideum, 2 Escherichia coli, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

7 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2040771 (F13M22.19 · AT2G37690 · F13M22_19) · NCBI:NP_181305.2⌘
A. thalianaNCBI:NP_178587.1 · TAIR:locus:2051314 (F5G3.4 · F5G3_4 · AT2G05140)⌘
D. discoideumUniProtKB:Q54QE4 · dictyBase:DDB_G0283987 (purC · purC/E · purE)PAICS, phosphoribosylaminoimidazole carboxylase (AIR carboxylase), phosphoribosylaminoimidazolesuccinocarboxamide synthase (SAICAR synthase)⌘
E. coliECOLI:PURE-MONOMER (ECK0516 · PurE · ade3 · b0523 · ade(f) · Pur2 · purE · ade) · UniProtKB:P0AG18⌘
E. coliUniProtKB:P09029 · ECOLI:PURK-MONOMER (b0522 · ECK0515 · purE2 · purK · PurK)N5-carboxyaminoimidazole ribonucleotide synthase monomer⌘
S. cerevisiaeUniProtKB:P21264 · SGD:S000005654 (YOR128C · ADE2)Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway⌘
S. pombeUniProtKB:P15567 · GeneDB_Spombe:SPCC1322.13 (min1 · SPCC1322.13 · ade6)phosphoribosylaminoimidazole carboxylase Ade6⌘
ProteinPublicationCurator Notes
UniProtKB:P21264 · SGD:S000005654PMID:17698621 Lüscher A, et al. Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites. Antimicrob Agents Chemother. 2007 Nov;51(11):3895-901.The T. brucei protein TbAT1 was expressed in S. cerevisiae, but complementation was not directly tested. Heterologous expression of T. brucei adenosine transporter allowed a yeast ade2 mutant to bypass adenosine synthesis by importing adenosine from the medium.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
Send questions, suggestions, and comments to: yfgdb@genomics.princeton.edu