P-POD: Princeton Protein Orthology Database: GO3/Nens52

This family has 131 members: 23 Arabidopsis thaliana, 10 Caenorhabditis elegans, 16 Danio rerio, 6 Dictyostelium discoideum, 7 Drosophila melanogaster, 13 Gallus gallus, 14 Homo sapiens, 14 Mus musculus, 13 Rattus norvegicus, 8 Saccharomyces cerevisiae, 7 Schizosaccharomyces pombe.

• Protein Family
• Functional Conservation (12)
• Download Files (5)
• Disease References (2)

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

131 members.

Organism	Protein (Synonyms)	Description	AmiGO
A. thaliana	NCBI:NP_193184.1 · TAIR:locus:2129780 (FCAALL.219 · AT4G14480 · DL3280C)
A. thaliana	NCBI:NP_180810.1 · TAIR:locus:2060246 (AT2G32510 · T26B15.7 · MAPKKK17 · T26B15_7)
A. thaliana	NCBI:NP_188140.1 · TAIR:locus:2087130 (K7L4.2 · AT3G15220)
A. thaliana	NCBI:NP_192811.4 · TAIR:locus:2132716 (T12H20_4 · T12H20.4 · AT4G10730)
A. thaliana	NCBI:NP_200469.1 · TAIR:locus:2164981 (MIK19.2 · MIK19_2 · ATMKK6 · MKK6 · ANQ1 · AT5G56580)	ARABIDOPSIS NQK1 · MAP KINASE KINASE 6 · ARABIDOPSIS THALIANA MAP KINASE KINASE 6
A. thaliana	NCBI:NP_172195.1 · TAIR:locus:2007337 (F10K1.14 · AT1G07150 · MAPKKK13 · F10K1_14)
A. thaliana	NCBI:NP_175724.2 · TAIR:locus:2824247 (F8L10.20 · AT1G53165)	ATMAP4K ALPHA1
A. thaliana	NCBI:NP_173782.1 · TAIR:locus:2034888 (F5O8_25 · F5O8.25 · AT1G23700)
A. thaliana	NCBI:NP_190600.1 · TAIR:locus:2074835 (AT3G50310 · F11C1.150 · MAPKKK20)
A. thaliana	NCBI:NP_196976.2 · TAIR:locus:2185440 (AT5G14720 · T9L3.20 · T9L3_20)
A. thaliana	NCBI:NP_201509.1 · TAIR:locus:2155568 (MAPKKK19 · K21H1_4 · K21H1.4 · AT5G67080)
A. thaliana	NCBI:NP_177200.1 · TAIR:locus:2016164 (F17O7_3 · AT1G70430 · F17O7.3)
A. thaliana	NCBI:NP_178082.3 · TAIR:locus:2019878 (F20B17_7 · AT1G79640 · F20B17.7)
A. thaliana	NCBI:NP_194419.2 · TAIR:locus:2116417 (F10M23_230 · MAPKKK16 · F10M23.230 · AT4G26890)
A. thaliana	NCBI:NP_198860.1 · TAIR:locus:2170578 (AT5G40440 · MPO12.150 · MPO12_150 · MKK3 · ATMKK3)	ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 · MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3
A. thaliana	NCBI:NP_001078504.1 · TAIR:locus:2114990
A. thaliana	NCBI:NP_564955.1 · TAIR:locus:2026459 (F4N2.24 · AT1G69220 · SIK1)	SERINE/THREONINE KINASE SIK1
A. thaliana	NCBI:NP_001031751.1 · TAIR:locus:2123909 (MKK2 · AT4G29810 · F27B13_50 · MK1 · F27B13.50 · ATMKK2)	MAP KINASE KINASE 1 · ARABIDOPSIS THALIANA MAP KINASE KINASE 2 · MAP KINASE KINASE 2
A. thaliana	NCBI:NP_194141.2 · TAIR:locus:2135016 (T19F6.90 · AT4G24100 · T19F6_90)
A. thaliana	NCBI:NP_200320.1 · TAIR:locus:2161690 (MCO15_4 · MCO15.4 · AT5G55090 · MAPKKK15)
A. thaliana	NCBI:NP_172003.1 · TAIR:locus:2205523 (T7A14.2 · AT1G05100 · MAPKKK18 · T7A14_2)
A. thaliana	NCBI:NP_194337.1 · TAIR:locus:2120855 (F20B18.180 · ATMEK1 · MEK1 · AT4G26070 · MKK1 · NMAPKK · F20B18_180)	MAP KINASE/ ERK KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 · MITOGEN ACTIVATED PROTEIN KINASE KINASE
A. thaliana	NCBI:NP_180565.1 · TAIR:locus:2045658 (F23F1_4 · F23F1.4 · MAPKKK14 · AT2G30040)
C. elegans	WB:WBGene00017472 (cst-1 · F14H12.4) · UniProtKB:Q9NB31
C. elegans	WB:WBGene00003186 (Y54E10BL.6 · mek-2) · UniProtKB:Q10664
C. elegans	WB:WBGene00003368 (F42G10.2 · mkk-4) · UniProtKB:Q20347 (MKK4_CAEEL · F42G10.2 · mkk-4)	MAP kinase kinase mkk-4
C. elegans	WB:WBGene00012162 (VZC374L.1) · UniProtKB:O01706
C. elegans	WB:WBGene00001526 (T19A5.2 · gck-1) · UniProtKB:Q22553 (T19A5.2 · gck-1)	Germinal center kinase family protein 1, isoform a
C. elegans	WB:WBGene00016038 (C24A8.4 · cst-2) · UniProtKB:Q304D8
C. elegans	WB:WBGene00022613 (ZC449.3) · UniProtKB:Q8MPS3
C. elegans	WB:WBGene00004758 (sek-1 · R03G5.2) · UniProtKB:Q95YI9 (sek-1 · R03G5.2)	MAP kinase kinase SEK-1
C. elegans	WB:WBGene00003472 (mtk-1 · B0414.7) · UniProtKB:Q960A2
C. elegans	WB:WBGene00013355 (Y59A8B.23 · gck-3) · UniProtKB:Q9GRY2
D. rerio	ENSEMBL:ENSDARP00000079474
D. rerio	ENSEMBL:ENSDARP00000090612
D. rerio	ENSEMBL:ENSDARP00000069816
D. rerio	ENSEMBL:ENSDARP00000026314
D. rerio	UniProtKB:Q7ZUQ3 · ZFIN:ZDB-GENE-030131-2845 (stk3)	serine/threonine kinase 3 (STE20 homolog, yeast)
D. rerio	ZFIN:ZDB-GENE-070424-52 (zgc:163071) · UniProtKB:A3KP89
D. rerio	UniProtKB:Q1LUY7 · ZFIN:ZDB-GENE-040426-2759 (map2k1)	mitogen-activated protein kinase kinase 1
D. rerio	UniProtKB:Q1LY62 · ZFIN:ZDB-GENE-041027-1 (map2k2)	mitogen-activated protein kinase kinase 2
D. rerio	ENSEMBL:ENSDARG00000069047 · UniProtKB:Q5BJ15
D. rerio	ZFIN:ZDB-GENE-041010-92 (zgc:92836) · UniProtKB:Q5XIY3
D. rerio	UniProtKB:Q7SYN3 · ZFIN:ZDB-GENE-040426-2841 (stk24)	serine/threonine kinase 24 (STE20 homolog, yeast)
D. rerio	UniProtKB:Q7ZVG8 · ZFIN:ZDB-GENE-040426-2537 (stk25)	serine/threonine kinase 25 (STE20 homolog, yeast)
D. rerio	UniProtKB:Q803V0 · ZFIN:ZDB-GENE-040426-723 (oxsr1b)	oxidative-stress responsive 1b
D. rerio	UniProtKB:Q9DGE0 · ZFIN:ZDB-GENE-010202-3 (map2k6)	mitogen-activated protein kinase kinase 6
D. rerio	UniProtKB:A5PLJ7 · ZFIN:ZDB-GENE-070620-25 (oxsr1a)	oxidative-stress responsive 1a
D. rerio	UniProtKB:B1NA68 · ZFIN:ZDB-GENE-060512-98 (map2k4)	mitogen-activated protein kinase kinase 4
D. discoideum	UniProtKB:Q54XL6 · dictyBase:DDB_G0278863 (DFray1 · fray1)	putative protein serine/threonine kinase, STE20 family protein kinase, protein kinase, STE group, FRAY subfamily protein kinase
D. discoideum	UniProtKB:Q551H4 · dictyBase:DDB_G0276577 (fray2 · DFray2)	putative protein serine/threonine kinase, STE20 family protein kinase, protein kinase, STE group, FRAY subfamily protein kinase
D. discoideum	UniProtKB:O61125 · dictyBase:DDB_G0284181 (krsA · Krs1)	protein serine/threonine kinase, krs1-like kinase, STE20 family protein kinase, protein kinase, STE group, MST subfamily kinase
D. discoideum	UniProtKB:O61122 · dictyBase:DDB_G0286359 (svkA)	severin kinase, protein serine/threonine kinase, STE20 family protein kinase, protein kinase, STE group, YST subfamily protein kinase
D. discoideum	UniProtKB:Q54PX0 · dictyBase:DDB_G0284251 (DDB_G0284251)	putative protein serine/threonine kinase, protein kinase, STE group
D. discoideum	UniProtKB:Q55CL6 · dictyBase:DDB_G0269152 (DdMEK1 · mekA · mek1)	MAP kinase kinase (MAP2K), STE7 family protein kinase, protein kinase, STE group
D. melanogaster	UniProtKB:Q24324 · FB:FBgn0010269 (D-mek · D-sor · MEK1/2 · D-sor-1 · D-Mek · Su(Raf)34B · D-MEK/Dsor · Sor · MEK · dMEK · D-MEK · Dsor1 · D-SOR · MEK/Dsor1 · MAPKK · CG15793 · EK1-1 · DSORT · DSor1 · DSor · Dsor · sor · dsor1 · Dmek · D-Sor · DRODSOR1 · mek · SOR · Mek · dSor · DSOR1 · DMEK-1 · sor/MEK1)	Map kinase kinase · Downstream of raf1 · MAPK kinase · downstream suppressor of Raf 1 · Drosophila MEK
D. melanogaster	FB:FBgn0034453 (CG11228 · Hpo · Hippo · hippo · MST2 · dMST · hpo) · UniProtKB:Q8T0S6
D. melanogaster	UniProtKB:O61444 · FB:FBgn0024326 (MKK4 · DMKK4 · CG9738 · CT27508 · mkk4 · D-MKK4 · SEK1/MKK4 · Mkk4 · dMKK4 · Mpk4 · 142758_at · JNKK2)	JNK kinase 2 · MAP kinase kinase 4 · Drosophila MAP kinase kinase 4
D. melanogaster	UniProtKB:Q8IGS1 · FB:FBgn0086736 (dGCKIII · CG5169 · GCKIII · GckIII · STLK3)	Germinal centre kinase III
D. melanogaster	UniProtKB:Q9U983 · FB:FBgn0015763 (p38MAPKK · MEK3/MKK3 · DMKK3 · lic · l(1)G0252 · DMEK3 · Mpk3 · p38 · MKK3 · D-MKK3 · CG12244 · licorne · DMKK3/lic · dMKK3 · Mek3)	MEK-kinase 3 · Drosophila MAP kinase kinase 3 · MAP kinase kinase 3
D. melanogaster	UniProtKB:Q9VE37 · FB:FBgn0024329 (mekk1a · MEKK · dMEKK4 · Mekk1/4 · dMEKK · mekk1 · D-MEKK1 · Mekk1 · D-Mekk1 · dMEKK1 · CG7717 · MEKK4 · DmMEKK1 · MEKK1 · mekk1b)
D. melanogaster	UniProtKB:Q9VE62 · FB:FBgn0023083 (Ste20-like · lag · frayed · fray · l(3)07551 · CG7693 · 4624 · laggard · STE20-like/SPAK · dSTRAD)	Ste20-like protein kinase
G. gallus	NCBI:XP_418527 · ENTREZ:420421
G. gallus	NCBI:XP_419617 · ENTREZ:421579
G. gallus	NCBI:XP_422019 · ENTREZ:424173
G. gallus	NCBI:XP_415583 · ENTREZ:417312
G. gallus	ENTREZ:396349 · UniProtKB:Q90891 (IPI00596185 · MKK2 · MAP2K2 · PRKMK2 · Q90891 · MP2K2_CHICK · MEK2)	Dual specificity mitogen-activated protein kinase kinase 2
G. gallus	ENTREZ:419187 · UniProtKB:Q5ZJK4 (RCJMB04_17i1 · STK4_CHICK · STK4 · Q5ZJK4 · IPI00651158)	Serine/threonine-protein kinase 4
G. gallus	UniProtKB:Q5F375 (IPI00591955 · RCJMB04_30a20 · Q5F375) · ENTREZ:418780
G. gallus	UniProtKB:Q5F3C3 (IPI00595669 · Q5F3C3 · RCJMB04_21o24) · ENTREZ:425375
G. gallus	UniProtKB:Q5ZHL2 (RCJMB04_36h7 · Q5ZHL2 · IPI00684847) · ENTREZ:415557
G. gallus	UniProtKB:Q5ZIF0 (RCJMB04_27f19 · IPI00580271 · Q5ZIF0) · ENTREZ:415549
G. gallus	UniProtKB:Q5ZL06 (Q5ZL06 · RCJMB04_8f10 · IPI00571597) · ENTREZ:416496
G. gallus	UniProtKB:Q5ZMA7 (IPI00577023 · Q5ZMA7 · RCJMB04_2k24) · ENTREZ:422231
G. gallus	ENTREZ:378801 · UniProtKB:Q6V9V7 (IPI00587961 · Q6V9V7)
H. sapiens	ENSEMBL:ENSG00000085511 · UniProtKB:Q9Y6R4 (MAP3K4 · MAPKKK4 · IPI00186536 · IPI00386260 · M3K4_HUMAN · MEKK4 · Q9Y6R4 · KIAA0213 · MTK1)	Mitogen-activated protein kinase kinase kinase 4
H. sapiens	ENSEMBL:ENSG00000169032 · UniProtKB:Q02750 (IPI00219604 · PRKMK1 · MEK1 · Q02750 · MP2K1_HUMAN · MAP2K1)	Dual specificity mitogen-activated protein kinase kinase 1
H. sapiens	ENSEMBL:ENSG00000126934 · UniProtKB:P36507 (MP2K2_HUMAN · IPI00003783 · MKK2 · P36507 · MAP2K2 · PRKMK2 · MEK2)	Dual specificity mitogen-activated protein kinase kinase 2
H. sapiens	ENSEMBL:ENSG00000034152 · UniProtKB:P46734 (MP2K3_HUMAN · MAP2K3 · P46734 · MEK3 · IPI00218857 · MKK3 · PRKMK3 · IPI00218858 · IPI00220438)	Dual specificity mitogen-activated protein kinase kinase 3
H. sapiens	ENSEMBL:ENSG00000065559 · UniProtKB:P45985 (MP2K4_HUMAN · MKK4 · MAP2K4 · IPI00024674 · JNKK1 · P45985 · SERK1 · PRKMK4)	Dual specificity mitogen-activated protein kinase kinase 4
H. sapiens	ENSEMBL:ENSG00000137764 · UniProtKB:Q13163 (PRKMK5 · Q13163 · MEK5 · IPI00158248 · MAP2K5 · IPI00219607 · IPI00185860 · MKK5 · MP2K5_HUMAN)	Dual specificity mitogen-activated protein kinase kinase 5
H. sapiens	ENSEMBL:ENSG00000108984 · UniProtKB:P52564 (PRKMK6 · P52564 · IPI00219569 · MEK6 · MP2K6_HUMAN · MAP2K6 · MKK6 · IPI00003814)	Dual specificity mitogen-activated protein kinase kinase 6
H. sapiens	ENSEMBL:ENSG00000134602 · UniProtKB:Q9P289 (Q9P289 · MST4_HUMAN · MASK · MST4 · IPI00292827)	Serine/threonine-protein kinase MST4
H. sapiens	ENSEMBL:ENSG00000172939 · UniProtKB:O95747 (OXSR1 · OSR1 · IPI00010080 · OXSR1_HUMAN · KIAA1101 · O95747)	Serine/threonine-protein kinase OSR1
H. sapiens	ENSEMBL:ENSG00000102572 · UniProtKB:Q9Y6E0 (STK24_HUMAN · IPI00335281 · IPI00002212 · MST3 · STK24 · STK3 · Q9Y6E0)	Serine/threonine-protein kinase 24
H. sapiens	ENSEMBL:ENSG00000115694 · UniProtKB:O00506 (SOK1 · STK25 · O00506 · IPI00012093 · YSK1 · STK25_HUMAN)	Serine/threonine-protein kinase 25
H. sapiens	ENSEMBL:ENSG00000198648 · UniProtKB:Q9UEW8 (STK39 · SPAK · IPI00004363 · STK39_HUMAN · Q9UEW8)	STE20/SPS1-related proline-alanine-rich protein kinase
H. sapiens	ENSEMBL:ENSG00000104375 · UniProtKB:Q13188 (STK3_HUMAN · STK3 · Q13188 · IPI00411984 · MST2)	Serine/threonine-protein kinase 3
H. sapiens	ENSEMBL:ENSG00000101109 · UniProtKB:Q13043 (STK4_HUMAN · MST1 · STK4 · Q13043 · IPI00011488 · IPI00645585)	Serine/threonine-protein kinase 4
M. musculus	UniProtKB:O08648 · MGI:MGI:1346875 (Map3k4 · RP17 · MAPKKK4 · MTK1 · Mekk4 · D17Rp17e · D17Rp17)	mitogen-activated protein kinase kinase kinase 4
M. musculus	UniProtKB:P31938 · MGI:MGI:1346866 (Prkmk1 · Mek1 · Map2k1)	MAP kinase kinase 1 · mitogen-activated protein kinase kinase 1
M. musculus	UniProtKB:Q63932 · MGI:MGI:1346867 (Map2k2 · Prkmk2 · MEK2)	MAP kinase/Erk kinase · mitogen-activated protein kinase kinase 2
M. musculus	UniProtKB:O09110 · MGI:MGI:1346868 (Prkmk3 · MKK3 · Map2k3)	mitogen-activated protein kinase kinase 3 · MAP kinase kinase 3
M. musculus	UniProtKB:P47809 · MGI:MGI:1346869 (MKK4 · Map2k4 · Serk1 · Sek1 · JNKK1)	mitogen-activated protein kinase kinase 4
M. musculus	UniProtKB:Q9WVS7 · MGI:MGI:1346345 (Mapkk5 · Prkmk5 · MEK5 · Map2k5)	MAPK/ERK kinase 5 · mitogen-activated protein kinase kinase 5
M. musculus	UniProtKB:P70236 · MGI:MGI:1346870 (Prkmk6 · SAPKK3 · Map2k6 · MKK6)	mitogen-activated protein kinase kinase 6 · MAP kinase kinase 6
M. musculus	UniProtKB:Q99JT2 · MGI:MGI:1917665 (2610018G03Rik)	RIKEN cDNA 2610018G03 gene
M. musculus	UniProtKB:Q6P9R2 · MGI:MGI:1917378 (Osr1 · Oxsr1)	oxidative-stress responsive 1
M. musculus	UniProtKB:Q99KH8 · MGI:MGI:2385007 (Stk24)	serine/threonine kinase 24 (STE20 homolog, yeast)
M. musculus	UniProtKB:Q9Z2W1 · MGI:MGI:1891699 (Ste20-like · Stk25 · Ysk1)	serine/threonine kinase 25 (yeast)
M. musculus	UniProtKB:Q9Z1W9 · MGI:MGI:1858416 (SPAK · Stk39 · DCHT)	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
M. musculus	UniProtKB:Q9JI10 · MGI:MGI:1928487 (mess1 · Mst2 · Stk3 · MST)	serine/threonine kinase 3 (Ste20, yeast homolog)
M. musculus	UniProtKB:Q9JI11 · MGI:MGI:1929004 (Ysk3 · Mst1 · Stk4 · Kas-2)	serine/threonine kinase 4
R. norvegicus	NCBI:XP_001063040 · RGD:1311192 (Map3k4)	mitogen activated protein kinase kinase kinase 4
R. norvegicus	NCBI:XP_341378 · RGD:1561742 (Stk24)	serine/threonine kinase 24 (STE20 homolog, yeast)
R. norvegicus	NCBI:XP_001070192 · RGD:1563568 (Mst4)	serine/threonine protein kinase MST4
R. norvegicus	NCBI:XP_236687 · RGD:1310466 (Oxsr1)	oxidative-stress responsive 1
R. norvegicus	UniProtKB:Q01986 · RGD:70495 (Map2k1)	mitogen activated protein kinase kinase 1
R. norvegicus	UniProtKB:P36506 · RGD:61888 (Map2k2)	mitogen activated protein kinase kinase 2
R. norvegicus	RGD:61890 (Map2k5) · UniProtKB:Q62862 (IPI00230847 · Mek5 · Prkmk5 · Map2k5 · Mkk5 · IPI00209255 · MP2K5_RAT · Q62862 · IPI00230846)	mitogen activated protein kinase kinase 5 · Dual specificity mitogen-activated protein kinase kinase 5
R. norvegicus	UniProtKB:O88506 · RGD:621643 (Stk39)	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)
R. norvegicus	UniProtKB:O54748 · RGD:68412 (Stk3)	serine/threonine kinase 3 (STE20 homolog, yeast)
R. norvegicus	UniProtKB:Q4KSH6 · RGD:1307040 (Map2k4)	mitogen activated protein kinase kinase 4
R. norvegicus	UniProtKB:Q6V9V9 · RGD:727809 (Stk25)	serine/threonine kinase 25 (STE20 homolog, yeast)
R. norvegicus	UniProtKB:Q925D6 · RGD:620666 (Map2k6)	mitogen-activated protein kinase kinase 6
R. norvegicus	NCBI:XP_001070199 · RGD:1312035 (Stk4)	serine/threonine kinase 4
S. cerevisiae	UniProtKB:P38692 · SGD:S000001144 (NRK1 · YHR102W · KIC1)	Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall
S. cerevisiae	UniProtKB:P32490 · SGD:S000005757 (SSP32 · YOR231W · MKK1)	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity
S. cerevisiae	UniProtKB:P32491 · SGD:S000006061 (LPI6 · MKK2 · SSP33 · YPL140C)	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity
S. cerevisiae	UniProtKB:P08018 · SGD:S000003664 (HOG4 · YJL128C · SSK4 · SFS4 · PBS2)	MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress
S. cerevisiae	UniProtKB:P08458 · SGD:S000002931 (YDR523C · SPS1)	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
S. cerevisiae	UniProtKB:P25390 · SGD:S000000669 (SSK22 · YCR073C)	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway
S. cerevisiae	UniProtKB:P53599 · SGD:S000005314 (SSK2 · YNR031C)	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway
S. cerevisiae	UniProtKB:P06784 · SGD:S000002318 (YDL159W · STE7)	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p
S. pombe	UniProtKB:P10506 · GeneDB_Spombe:SPAC1D4.13 (ste1 · SPAC1D4.13 · byr1 · ste3)	MAP kinase kinase Byr1
S. pombe	UniProtKB:O14047 · GeneDB_Spombe:SPAC2C4.14c (SPAC2C4.14c · ppk11)	PAK-related kinase Ppk11
S. pombe	UniProtKB:O14305 · GeneDB_Spombe:SPAC9G1.09 (SPAC9G1.09 · sid1)	PAK-related kinase Sid1
S. pombe	UniProtKB:Q9Y884 · GeneDB_Spombe:SPBC543.07 (mkk1 · SPBC543.07 · pek1 · skh1)	MAP kinase kinase Pek1
S. pombe	UniProtKB:O74304 · GeneDB_Spombe:SPAC1006.09 (win1 · SPAC1006.09 · SPAC1250.06c · SPAPJ730.01)	MAP kinase kinase kinase Win1
S. pombe	UniProtKB:P33886 · GeneDB_Spombe:SPBC409.07c (wis1 · smf2 · spc2 · SPBC409.07c)	MAP kinase kinase Wis1
S. pombe	UniProtKB:O14299 · GeneDB_Spombe:SPAC9G1.02 (wik1 · wis4 · wak1 · SPAC9G1.02)	MAP kinase kinase kinase Wis4

Protein	Publication	Curator Notes
UniProtKB:P08018 · SGD:S000003664	15707964 Sharma P, et al. Evidence that C-terminal non-kinase domain of Pbs2p has a role in high osmolarity-induced nuclear localization of Hog1p. Biochem Biophys Res Commun. 2005 Mar 25;328(4):906-13.	The D. hansenii protein DPBS2 complements a homologous mutation in S. cerevisiae. This paper shows that D. hansenii DPBS2 partially complements a yeast pbs2 null mutant.
UniProtKB:P32490 · SGD:S000005757	8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.	The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P32491 · SGD:S000006061	8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.	The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P08018 · SGD:S000003664	8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.	The C. albicans protein HST7 was expressed in S. cerevisiae, but complementation was not directly tested.
UniProtKB:P06784 · SGD:S000002318	8544826 Clark KL, et al. Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans. Mol Gen Genet. 1995 Dec 20;249(6):609-21.	The C. albicans protein HST7 complements a homologous mutation in S. cerevisiae.
UniProtKB:P08018 · SGD:S000003664	17349032 Lenassi M, et al. The MAP kinase HwHog1 from the halophilic black yeast Hortaea werneckii: coping with stresses in solar salterns. Saline Systems. 2007;3:3.	The H. werneckii protein HwHOG1 was expressed in S. cerevisiae, but complementation was not directly tested. This paper shows functional expression of H. werneckii HwHOG1 in an S. cerevisiae pbs2 null mutant.
UniProtKB:P08018 · SGD:S000003664	12704083 Soyano T, et al. NQK1/NtMEK1 is a MAPKK that acts in the NPK1 MAPKKK-mediated MAPK cascade and is required for plant cytokinesis. Genes Dev. 2003 Apr 15;17(8):1055-67.	The N. tabacum protein NQK1 complements a homologous mutation in S. cerevisiae.
UniProtKB:P06784 · SGD:S000002318	16318282 Du H, et al. Cloning and characterization of a dual-specificity kinase gene in rice (Oryza sative). Yi Chuan Xue Bao. 2005 Nov;32(11):1167-75.	The O. sativa protein OsSTY complements a homologous mutation in S. cerevisiae. This paper shows that O. sativa OsSTY serine/threonine/tyrosine kinase partially complements a yeast ste7 null mutant.
UniProtKB:P08018 · SGD:S000003664	15882418 Furukawa K, et al. Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress. Mol Microbiol. 2005 Jun;56(5):1246-61.	The A. nidulans protein pbsB complements a homologous mutation in S. cerevisiae.
UniProtKB:P25390 · SGD:S000000669	9305639 Takekawa M, et al. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 1997 Aug 15;16(16):4973-82.	The H. sapiens protein Q9Y6R4 complements a homologous mutation in S. cerevisiae. Although human MTK1 (Q9Y6R4) was cloned by functional complementation of the yeast ssk2 ssk22 sho1 triple mutant, MTK1 shows stronger homology to yeast Ssk2/Ssk22 and MTK1 can functionally replace Ssk2 and Ssk22 in the yeast HOG MAP kinase pathway.
UniProtKB:P53599 · SGD:S000005314	12857882 Yuzyuk T, et al. Actin recovery and bud emergence in osmotically stressed cells requires the conserved actin interacting mitogen-activated protein kinase kinase kinase Ssk2p/MTK1 and the scaffold protein Spa2p. Mol Biol Cell. 2003 Jul;14(7):3013-26.	The H. sapiens protein Q9Y6R4 complements a homologous mutation in S. cerevisiae. Human MTK1 (Q9Y6R4) was shown to complement the actin recovery defects of osmotically stressed yeast ssk2 mutants.
UniProtKB:P53599 · SGD:S000005314	9305639 Takekawa M, et al. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 1997 Aug 15;16(16):4973-82.	The H. sapiens protein Q9Y6R4 complements a homologous mutation in S. cerevisiae. Although human MTK1 (Q9Y6R4) was cloned by functional complementation of the yeast ssk2 ssk22 sho1 triple mutant, MTK1 shows stronger homology to yeast Ssk2/Ssk22 and MTK1 can functionally replace Ssk2 and Ssk22 in the yeast HOG MAP kinase pathway.

Description	Suffix
Sequences in this family	.fasta
mafft aligned Fasta file	.afasta
phyml newick file	.newick
Notung rooted & rearranged newick file	.newick.rooting.0.rearrange.0
Notung Homolog Table	.newick.rooting.0.rearrange.0.homologs.csv

OMIM (2)
ENSEMBL:ENSG00000126934 · UniProtKB:P36507	#115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME
ENSEMBL:ENSG00000126934 · UniProtKB:P36507	#115150 CARDIOFACIOCUTANEOUS SYNDROME;;CFC SYNDROME