P-POD: Princeton Protein Orthology Database: GO3/Nens3386

This family has 11 members: 1 Arabidopsis thaliana, 1 Caenorhabditis elegans, 1 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Gallus gallus, 1 Homo sapiens, 1 Mus musculus, 1 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

11 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaTAIR:locus:2168833 (MNF13.22 · MNF13_22 · AT5G40660) · NCBI:NP_198882.1⌘
C. elegansWB:WBGene00013804 (Y116A8C.27) · UniProtKB:Q9U2U3⌘
D. rerioENSEMBL:ENSDARG00000056270 · UniProtKB:A3KP55
D. discoideumdictyBase:DDB_G0292678 · UniProtKB:Q54CV4
D. melanogasterUniProtKB:Q8T3M6 · FB:FBgn0021856 (l(2)k14505 · CG8674)lethal (2) k14505⌘
G. gallusNCBI:XP_414815 · ENTREZ:416511
H. sapiensENSEMBL:ENSG00000171953 · UniProtKB:Q8N5M1 (LP3663 · Q8N5M1 · ATP12 · ATPF2_HUMAN · IPI00296999 · ATPAF2)ATP synthase mitochondrial F1 complex assembly factor 2⌘
M. musculusUniProtKB:Q91YY4 · MGI:MGI:2180561 (ATP12p · ATP12 · Atpaf2)ATP synthase mitochondrial F1 complex assembly factor 2⌘
R. norvegicusNCBI:XP_220522 · RGD:1305161 (Atpaf2)ATP synthase mitochondrial F1 complex assembly factor 2⌘
S. cerevisiaeUniProtKB:P22135 · SGD:S000003716 (YJL180C · ATP12)Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase⌘
S. pombeUniProtKB:Q9UT16 · GeneDB_Spombe:SPAC9.12c (SPAC9.12c · atp12)F1-ATPase chaperone Atp12⌘
ProteinPublicationCurator Notes
UniProtKB:P22135 · SGD:S000003716PMID:19933271 Meulemans A, et al. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. J Biol Chem. 2010 Feb 5;285(6):4099-109.The H. sapiens protein ATPAF2 complements a homologous mutation in S. cerevisiae.
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (1)
SGD Disease Papers (2)
UniProtKB:P22135 · SGD:S000003716PMID:14757859 De Meirleir L, et al. (2004) Respiratory chain complex V deficiency due to a mutation in the assembly gene ATP12. J Med Genet 41(2):120-4
PMID:12206899 Ackerman SH (2002) Atp11p and Atp12p are chaperones for F(1)-ATPase biogenesis in mitochondria. Biochim Biophys Acta 1555(1-3):101-5
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