This family has 42 members: 2 Caenorhabditis elegans, 11 Danio rerio, 3 Dictyostelium discoideum, 1 Drosophila melanogaster, 7 Gallus gallus, 6 Homo sapiens, 6 Mus musculus, 5 Rattus norvegicus, 1 Saccharomyces cerevisiae.
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| Organism | Protein (Synonyms) | Description | AmiGO |
|---|---|---|---|
| C. elegans | UniProtKB:P34295 · WB:WBGene00004344 (C05B5.7 · rgs-1) |  | |
| C. elegans | WB:WBGene00004345 (F16H9.1 · rgs-2) · UniProtKB:Q9TVK0 | | |
| D. rerio | ENSEMBL:ENSDARP00000016941 | ||
| D. rerio | ENSEMBL:ENSDARP00000073904 | ||
| D. rerio | ENSEMBL:ENSDARP00000030228 | ||
| D. rerio | ENSEMBL:ENSDARP00000050870 | ||
| D. rerio | ENSEMBL:ENSDARG00000071447 · UniProtKB:Q4V987 | ||
| D. rerio | ZFIN:ZDB-GENE-050417-359 (zgc:110206) · UniProtKB:Q568M8 | | |
| D. rerio | ZFIN:ZDB-GENE-050417-393 (zgc:110164) · UniProtKB:Q568Q4 | | |
| D. rerio | UniProtKB:Q6DGR5 · ZFIN:ZDB-GENE-040718-229 (rgs17) | regulator of G-protein signaling 17 | |
| D. rerio | UniProtKB:Q6DH47 · ZFIN:ZDB-GENE-040718-128 (rgs20) | regulator of G-protein signaling 20 | |
| D. rerio | ZFIN:ZDB-GENE-070410-138 (zgc:163081) · UniProtKB:A5WW80 | | |
| D. rerio | ZFIN:ZDB-GENE-040801-150 (zgc:100933) · UniProtKB:Q6DC84 | | |
| D. discoideum | NCBI:EAL71154.1 · dictyBase:DDB_G0273033 | ||
| D. discoideum | dictyBase:DDB_G0282583 (DDB_G0282583) · UniProtKB:Q54S99 | | |
| D. discoideum | dictyBase:DDB_G0274041 (DDB_G0274041) · UniProtKB:Q556I3 | | |
| D. melanogaster | FB:FBgn0028743 (CG5036 · EG:52C10.2) · UniProtKB:Q8T017 | | |
| G. gallus | NCBI:XP_422252 · ENTREZ:424409 | ||
| G. gallus | NCBI:XP_422203 · ENTREZ:424360 | ||
| G. gallus | NCBI:XP_001235303 · ENTREZ:772120 | ||
| G. gallus | NCBI:XP_001233243 · ENTREZ:769930 | ||
| G. gallus | ENTREZ:395645 · UniProtKB:Q9PWA0 (RGS17_CHICK · Q9PWA0 · RGS17 · IPI00598424) | Regulator of G-protein signaling 17 | |
| G. gallus | ENTREZ:395646 · UniProtKB:Q9PWA1 (RGS20_CHICK · IPI00596478 · RGS20 · Q9PWA1) | Regulator of G-protein signaling 20 | |
| G. gallus | UniProtKB:Q8AYF2 (Q8AYF2 · IPI00588841 · RGS-GAIP) · ENTREZ:374070 | | |
| H. sapiens | ENSEMBL:ENSG00000143333 · UniProtKB:O15492 (RGSR · O15492 · IPI00289948 · RGS16_HUMAN · RGS16) | Regulator of G-protein signaling 16 | |
| H. sapiens | ENSEMBL:ENSG00000091844 · UniProtKB:Q9UGC6 (RGS17 · Q9UGC6 · IPI00005250 · RGS17_HUMAN) | Regulator of G-protein signaling 17 | |
| H. sapiens | ENSEMBL:ENSG00000171700 · UniProtKB:P49795 (RGS19_HUMAN · GNAI3IP · P49795 · RGS19 · IPI00028108 · GAIP) | Regulator of G-protein signaling 19 | |
| H. sapiens | ENSEMBL:ENSG00000090104 · UniProtKB:Q08116 (BL34 · RGS1_HUMAN · IER1 · RGS1 · Q08116 · 1R20 · IPI00873849) | Regulator of G-protein signaling 1 | |
| H. sapiens | ENSEMBL:ENSG00000147509 · UniProtKB:O76081 (IPI00220883 · RGS20_HUMAN · IPI00008802 · RGS20 · O76081 · IPI00220884 · ZGAP1 · RGSZ1 · IPI00220881 · IPI00220880 · IPI00220882) | Regulator of G-protein signaling 20 | |
| H. sapiens | ENSEMBL:ENSG00000215825 · UniProtKB:Q2M5E4 (RGS21 · Q2M5E4 · RGS21_HUMAN · IPI00719155) | Regulator of G-protein signaling 21 | |
| M. musculus | NCBI:XP_921002 · MGI:MGI:3645243 | ||
| M. musculus | UniProtKB:P97428 · MGI:MGI:108407 (Rgs16 · Rgsr) | regulator of G-protein signaling 16 | |
| M. musculus | UniProtKB:Q9QZB0 · MGI:MGI:1927469 (RGSZ2 · Rgs17) | regulator of G-protein signaling 17 | |
| M. musculus | UniProtKB:Q9CX84 · MGI:MGI:1915153 (Rgs19) | regulator of G-protein signaling 19 | |
| M. musculus | UniProtKB:Q9JL25 · MGI:MGI:1354694 (BL34 · Rgs1) | regulator of G-protein signaling 1 | |
| M. musculus | UniProtKB:Q9QZB1 · MGI:MGI:1929866 (Rgsz1 · Rgs20) | regulator of G-protein signaling 20 | |
| R. norvegicus | NCBI:XP_001068374 · RGD:1586146 (Rgs20) | regulator of G-protein signaling 20 | |
| R. norvegicus | NCBI:XP_217837 · RGD:1305515 | ||
| R. norvegicus | UniProtKB:P56700 · RGD:1589741 (Rgs16) | regulator of G-protein signaling 16 | |
| R. norvegicus | UniProtKB:O70521 · RGD:629471 (Rgs19) | regulator of G-protein signaling 19 | |
| R. norvegicus | UniProtKB:P97844 · RGD:3561 (Rgs1) | regulator of G-protein signaling 1 | |
| S. cerevisiae | UniProtKB:Q99188 · SGD:S000005633 (RGS2 · YOR107W) | Negative regulator of glucose-induced cAMP signaling | |
| Protein | Publication | Curator Notes | |
|---|---|---|---|
| UniProtKB:Q99188 · SGD:S000005633 |  10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The M. musculus protein O08849 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 14607274 Li XY, et al. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Cell Signal. 2004 Jan;16(1):43-9. | The H. sapiens protein O15492 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 14607274 Li XY, et al. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Cell Signal. 2004 Jan;16(1):43-9. | The H. sapiens protein O15539 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 14607274 Li XY, et al. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Cell Signal. 2004 Jan;16(1):43-9. | The H. sapiens protein RGS1 (protein ID unknown) complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 14607274 Li XY, et al. Galpha protein dependent and independent effects of human RGS1 expression in yeast. Cell Signal. 2004 Jan;16(1):43-9. | The M. musculus protein RGS2 (protein ID unknown) complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The M. musculus protein O08850 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The H. sapiens protein P41220 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The H. sapiens protein P49796 does not complement a homologous mutation in S. cerevisiae. A truncated form of RGS3, RGS3T, also fails to complement. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The M. musculus protein P97428 complements a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The H. sapiens protein Q08116 does not complement a homologous mutation in S. cerevisiae. | |
| UniProtKB:Q99188 · SGD:S000005633 | 10523302 Versele M, et al. A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2. EMBO J. 1999 Oct 15;18(20):5577-91. | The R. norvegicus protein Rgs4 complements a homologous mutation in S. cerevisiae. |
| Description | Suffix |
|---|---|
| Sequences in this family | .fasta |
| mafft aligned Fasta file | .afasta |
| phyml newick file | .newick |
| Notung rooted & rearranged newick file | .newick.rooting.0.rearrange.0 |
| Notung Homolog Table | .newick.rooting.0.rearrange.0.homologs.csv |