P-POD: Princeton Protein Orthology Database: GO3/Nens230

This family has 52 members: 4 Arabidopsis thaliana, 4 Caenorhabditis elegans, 7 Danio rerio, 1 Dictyostelium discoideum, 1 Drosophila melanogaster, 1 Escherichia coli, 6 Gallus gallus, 6 Homo sapiens, 11 Mus musculus, 9 Rattus norvegicus, 1 Saccharomyces cerevisiae, 1 Schizosaccharomyces pombe.

Interactive Java Applets: Notung Tree Analysis · Jalview Alignment

GO3/Nens230
52 members.
OrganismProtein (Synonyms)DescriptionAmiGO
A. thalianaNCBI:NP_849779.1 · TAIR:locus:2203771 (AT3BETAHSD/D · T3F24_9 · AT3BETAHSD/D1 · T3F24.9 · AT1G47290)3BETA-HYDROXYSTEROID-DEHYDROGENASE/DECARBOXYLASE ISOFORM 1⌘
A. thalianaNCBI:NP_180194.2 · TAIR:locus:2057786 (AT3BETAHSD/D · AT3BETAHSD/D2 · AT2G26260 · T1D16_10 · T1D16.10)3BETA-HYDROXYSTEROID-DEHYDROGENASE/DECARBOXYLASE ISOFORM 2⌘
A. thalianaNCBI:NP_180921.1 · TAIR:locus:2051063 (AT2G33630 · F4P9_40 · F4P9.40)⌘
A. thalianaNCBI:NP_565998.1 · TAIR:locus:2058223 (T1O24.16 · AT2G43420)⌘
C. elegansWB:WBGene00022616 (hsd-3 · ZC449.6) · UniProtKB:A4UVJ7⌘
C. elegansWB:WBGene00016319 (C32D5.12) · UniProtKB:Q09491⌘
C. elegansWB:WBGene00022498 (ZC8.1 · hsd-2) · UniProtKB:Q23086⌘
C. elegansWB:WBGene00012394 (Y6B3B.11 · hsd-1) · UniProtKB:Q9XWF0⌘
D. rerioENSEMBL:ENSDARP00000088347
D. rerioENSEMBL:ENSDARP00000078285
D. rerioZFIN:ZDB-GENE-051120-63 (zgc:123280) · UniProtKB:Q32LS5⌘
D. rerioUniProtKB:Q566U2 · ZFIN:ZDB-GENE-050417-163 (nsdhl)NAD(P) dependent steroid dehydrogenase-like⌘
D. rerioENSEMBL:ENSDARG00000069926 · UniProtKB:Q6GMH6
D. rerioUniProtKB:Q7ZVQ1 · ZFIN:ZDB-GENE-030131-5673 (hsd3b7)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase⌘
D. rerioUniProtKB:Q7ZZC3 · ZFIN:ZDB-GENE-030828-2 (hsd3b1)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1⌘
D. discoideumUniProtKB:Q54TU9 · dictyBase:DDB_G0281487 (DDB_G0281487)3beta-hydroxysteroid dehydrogenase, putative sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)⌘
D. melanogasterFB:FBgn0036698 (CG7724) · UniProtKB:Q9VVE3⌘
E. coliUniProtKB:P75821 · ECOLI:G6453-MONOMER (b0868 · YbjS · ybjS · ECK0859)predicted NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain⌘
G. gallusNCBI:XP_415754 · ENTREZ:417505
G. gallusNCBI:XP_414167 · ENTREZ:415806
G. gallusNCBI:XP_420279 · ENTREZ:422302
G. gallusNCBI:XP_001234893 · ENTREZ:771638
G. gallusNCBI:XP_414919 · ENTREZ:416618
G. gallusUniProtKB:Q91997 (Q91997 · IPI00581332) · ENTREZ:396015⌘
H. sapiensENSEMBL:ENSG00000203857 · UniProtKB:P14060 (HSDB3A · 3BHS1_HUMAN · IPI00843838 · P14060 · 3BH · HSD3B1)3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1⌘
H. sapiensENSEMBL:ENSG00000203859 · UniProtKB:P26439 (IPI00218494 · 3BHS2_HUMAN · HSD3B2 · P26439 · HSDB3B)3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2⌘
H. sapiensENSEMBL:ENSG00000099377 · UniProtKB:Q9H2F3 (IPI00106783 · Q9H2F3 · 3BHS7_HUMAN · HSD3B7)3 beta-hydroxysteroid dehydrogenase type 7⌘
H. sapiensENSEMBL:ENSG00000147383 · UniProtKB:Q15738 (Q15738 · H105E3 · IPI00019407 · NSDHL_HUMAN · NSDHL)Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating⌘
H. sapiensENSEMBL:ENSG00000184860 · UniProtKB:Q8WUS8 (IPI00163504 · HSPC105 · Q8WUS8 · YP022_HUMAN)3-beta-HSD family protein HSPC105⌘
H. sapiensENSEMBL:ENSG00000183921 · UniProtKB:A6NKP2 (IPI00396920 · A6NKP2 · YP030_HUMAN)Putative 3-beta-HSD family protein ENSP00000330812⌘
M. musculusNCBI:XP_001480538 · MGI:MGI:3711284
M. musculusNCBI:XP_001480548 · MGI:MGI:3782634
M. musculusUniProtKB:P24815 · MGI:MGI:96233 (D3Ertd383e · Hsd3b1)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1⌘
M. musculusUniProtKB:P26149 · MGI:MGI:96234 (Hsd3b2)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2⌘
M. musculusUniProtKB:P26150 · MGI:MGI:96235 (Hsd3b3)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3⌘
M. musculusUniProtKB:Q61767 · MGI:MGI:96236 (Hsd3b4)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 · 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase⌘
M. musculusUniProtKB:Q61694 · MGI:MGI:104645 (3(beta)HSDV · Hsd3b5)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5⌘
M. musculusUniProtKB:O35469 · MGI:MGI:109598 (Hsd3b6)3beta-HSD VI · hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6⌘
M. musculusUniProtKB:Q9EQC1 · MGI:MGI:2141879 (Hsd3b7)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7⌘
M. musculusUniProtKB:Q9R1J0 · MGI:MGI:1099438 (striated · Nsdhl · XAP104 · H105E3 · Str · Bpa)NAD(P) dependent steroid dehydrogenase-like · bare patches⌘
M. musculusUniProtKB:Q9D665 · MGI:MGI:1921282 (Sdr42e1)short chain dehydrogenase/reductase family 42E, member 1⌘
R. norvegicusNCBI:XP_001079319 · RGD:1584167 (LOC687599)similar to NAD(P) dependent steroid dehydrogenase-like⌘
R. norvegicusNCBI:XP_226509 · RGD:1308481 (Sdr42e1)short chain dehydrogenase/reductase family 42E, member 1⌘
R. norvegicusNCBI:XP_219290 · RGD:1588549
R. norvegicusUniProtKB:P22071 · RGD:1308676 (Hsd3b1)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1⌘
R. norvegicusUniProtKB:P22072 · RGD:1592771 (Hsd3b)3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type II⌘
R. norvegicusUniProtKB:Q62878 · RGD:67377 (Hsd3b6)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6⌘
R. norvegicusUniProtKB:P27364 · RGD:2838 (Hsd3b5)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5⌘
R. norvegicusUniProtKB:O35048 · RGD:628727 (Hsd3b7)hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7⌘
R. norvegicusUniProtKB:Q5PPL3 · RGD:1359337 (Nsdhl)NAD(P) dependent steroid dehydrogenase-like⌘
S. cerevisiaeUniProtKB:P53199 · SGD:S000002969 (ERG26 · YGL001C)C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis⌘
S. pombeUniProtKB:O43050 · GeneDB_Spombe:SPBC3F6.02c (SPBC3F6.02c)3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase⌘
ProteinPublicationCurator Notes
UniProtKB:P53199 · SGD:S000002969PMID:14567972 Lucas ME, et al. Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast. Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33.The M. musculus protein Q9R1J0 complements a homologous mutation in S. cerevisiae.
UniProtKB:P53199 · SGD:S000002969PMID:14567972 Lucas ME, et al. Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast. Mol Genet Metab. 2003 Sep-Oct;80(1-2):227-33.The M. musculus protein Nsdhl complements a homologous mutation in S. cerevisiae.
DescriptionSuffix
Sequences in this family.fasta
mafft aligned Fasta file.afasta
phyml newick file.newick
Notung rooted & rearranged newick file.newick.rooting.0.rearrange.0
Notung Homolog Table.newick.rooting.0.rearrange.0.homologs.csv
OMIM (3)
ENSEMBL:ENSG00000099377 · UniProtKB:Q9H2F3+201810 3-@BETA-HYDROXYSTEROID DEHYDROGENASE, TYPE II, DEFICIENCY OF;;3-@BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY;;3-@BETA-HSD DEFICIENCY; HSDB;;ADRENAL HYPERPLASIA II3-@BETA-HYDROXYSTEROID DEHYDROGENASE/DELTA-ISOMERASE, TYPE II, INCLUDED;HSD3B2;;3-@BETA-HSD, ADRENAL AND GONADAL TYPE, INCLUDED
ENSEMBL:ENSG00000147383 · UniProtKB:Q15738#607765 BILE ACID SYNTHESIS DEFECT, CONGENITAL, 1;;CBAS1;;3-@BETA-HYDROXY-DELTA-5-C27-STEROID OXIDOREDUCTASE, DEFICIENCY OF
ENSEMBL:ENSG00000147383 · UniProtKB:Q15738#308050 CONGENITAL HEMIDYSPLASIA WITH ICHTHYOSIFORM ERYTHRODERMA AND LIMBDEFECTS;;CHILD SYNDROME;;ICHTHYOSIFORM ERYTHRODERMA, UNILATERAL, WITH IPSILATERAL MALFORMATIONS,ESPECIALLY ABSENCE DEFORMITY OF LIMBS
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